An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

por Willoughby, Lee F., Schlosser, Tanja, Manning, Samuel A., Parisot, John P., Street, Ian P., Richardson, Helena E., Humbert, Patrick O., Brumby, Anthony M.
Publicado 2013

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

por Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publicado 2011

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

por Cursons, Joseph, Leuchowius, Karl-Johan, Waltham, Mark, Tomaskovic-Crook, Eva, Foroutan, Momeneh, Bracken, Cameron P, Redfern, Andrew, Crampin, Edmund J, Street, Ian, Davis, Melissa J, Thompson, Erik W
Publicado 2015

Fragment screening for a protein-protein interaction inhibitor to WDR5

por Dennis, Matthew L., Morrow, Benjamin J., Dolezal, Olan, Cuzzupe, Anthony N., Stupple, Alexandra E., Newman, Janet, Bentley, John, Hattarki, Meghan, Nuttall, Stewart D., Foitzik, Richard C., Street, Ian P., Stupple, Paul A., Monahan, Brendon J., Peat, Thomas. S.
Publicado 2019

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

por AbuHammad, Shatha, Cullinane, Carleen, Martin, Claire, Bacolas, Zoe, Ward, Teresa, Chen, Huiqin, Slater, Alison, Ardley, Kerry, Kirby, Laura, Chan, Keefe T., Brajanovski, Natalie, Smith, Lorey K., Rao, Aparna D., Lelliott, Emily J., Kleinschmidt, Margarete, Vergara, Ismael A., Papenfuss, Anthony T., Lau, Peter, Ghosh, Prerana, Haupt, Sue, Haupt, Ygal, Sanij, Elaine, Poortinga, Gretchen, Pearson, Richard B., Falk, Hendrik, Curtis, David J., Stupple, Paul, Devlin, Mark, Street, Ian, Davies, Michael A., McArthur, Grant A., Sheppard, Karen E.
Publicado 2019

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

por Grohmann, Christoph, Walker, Francesca, Devlin, Mark, Luo, Meng-Xiao, Chüeh, Anderly C., Doherty, Judy, Vaillant, François, Ho, Gwo-Yaw, Wakefield, Matthew J., Weeden, Clare E., Kamili, Alvin, Murray, Jayne, Po’uha, Sela T., Weinstock, Janet, Kane, Serena R., Faux, Maree C., Broekhuizen, Esmee, Zheng, Ye, Shield-Artin, Kristy, Kershaw, Nadia J., Tan, Chin Wee, Witchard, Helen M., Ebert, Gregor, Charman, Susan A., Street, Ian, Kavallaris, Maria, Haber, Michelle, Fletcher, Jamie I., Asselin-Labat, Marie-Liesse, Scott, Clare L., Visvader, Jane E., Lindeman, Geoffrey J., Watson, Keith G., Burgess, Antony W., Lessene, Guillaume
Publicado 2021