Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

por Madan, Ajay, Markison, Stacy, Betz, Stephen F., Krasner, Alan, Luo, Rosa, Jochelson, Theresa, Lickliter, Jason, Struthers, R. Scott
Publicado 2022

ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly

por Gadelha, Monica R, Gordon, Murray B, Doknic, Mirjana, Mezősi, Emese, Tóth, Miklós, Randeva, Harpal, Marmon, Tonya, Jochelson, Theresa, Luo, Rosa, Monahan, Michael, Madan, Ajay, Ferrara-Cook, Christine, Struthers, R Scott, Krasner, Alan
Publicado 2022

Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist

por Zhao, Jian, Wang, Shimiao, Markison, Stacy, Kim, Sun Hee, Han, Sangdon, Chen, Mi, Kusnetzow, Ana Karin, Rico-Bautista, Elizabeth, Johns, Michael, Luo, Rosa, Struthers, R. Scott, Madan, Ajay, Zhu, Yunfei, Betz, Stephen F.
Publicado 2022