Progress in understanding 2-hydroxyglutaric acidurias

por Kranendijk, Martijn, Struys, Eduard A., Salomons, Gajja S., Van der Knaap, Marjo S., Jakobs, Cornelis
Publicado 2012

The measurement of urinary Δ(1)-piperideine-6-carboxylate, the alter ego of α-aminoadipic semialdehyde, in Antiquitin deficiency

por Struys, Eduard A., Bok, Levinus A., Emal, Dina, Houterman, Saskia, Willemsen, Michel A., Jakobs, Cornelis
Publicado 2012

Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4(+) T Cells

por Hegedus, Andrea, Kavanagh Williamson, Maia, Khan, Mariam B., Dias Zeidler, Julianna, Da Poian, Andrea T., El-Bacha, Tatiana, Struys, Eduard A., Huthoff, Hendrik
Publicado 2017

No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture

por van Ziel, Anna M., Wolzak, Kimberly, Nölle, Anna, Hoetjes, Petrus J., Berenjeno‐Correa, Ernesto, van Anken, Eelco, Struys, Eduard A., Scheper, Wiep
Publicado 2019

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

por Ralser, Markus, Wamelink, Mirjam M, Kowald, Axel, Gerisch, Birgit, Heeren, Gino, Struys, Eduard A, Klipp, Edda, Jakobs, Cornelis, Breitenbach, Michael, Lehrach, Hans, Krobitsch, Sylvia
Publicado 2007

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia

por Wiseman, Daniel H., Williams, Emma L., Wilks, Deepti P., Sun Leong, Hui, Somerville, Tim D. D., Dennis, Michael W., Struys, Eduard A., Bakkali, Abdellatif, Salomons, Gajja S., Somervaille, Tim C. P.
Publicado 2016

IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis

por Gao, Ya, de Wit, Maurice, Struys, Eduard A., van der Linde, Herma C. Z., Salomons, Gajja S., Lamfers, Martine L. M., Willemsen, Rob, Sillevis Smitt, Peter A. E., French, Pim J.
Publicado 2018

Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages

por Muller, Ittai B., Lin, Marry, de Jonge, Robert, Will, Nico, López-Navarro, Baltasar, van der Laken, Conny, Struys, Eduard A., Oudejans, Cees B. M., Assaraf, Yehuda G., Cloos, Jacqueline, Puig-Kröger, Amaya, Jansen, Gerrit
Publicado 2023

Fecal Amino Acid Analysis in Newly Diagnosed Pediatric Inflammatory Bowel Disease: A Multicenter Case-Control Study

por Jagt, Jasmijn Z, Struys, Eduard A, Ayada, Ibrahim, Bakkali, Abdellatif, Jansen, Erwin E W, Claesen, Jürgen, van Limbergen, Johan E, Benninga, Marc A, de Boer, Nanne K H, de Meij, Tim G J
Publicado 2021

A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors

por Khurshed, Mohammed, Molenaar, Remco J., van Linde, Myra E., Mathôt, Ron A., Struys, Eduard A., van Wezel, Tom, van Noorden, Cornelis J. F., Klümpen, Heinz-Josef, Bovée, Judith V. M. G., Wilmink, Johanna W.
Publicado 2021

In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site

por Chaturvedi, Anuhar, Goparaju, Ramya, Gupta, Charu, Weder, Julia, Klünemann, Thomas, Araujo Cruz, Michelle Maria, Kloos, Arnold, Goerlich, Kerstin, Schottmann, Renate, Othman, Basem, Struys, Eduard A., Bähre, Heike, Grote-Koska, Denis, Brand, Korbinian, Ganser, Arnold, Preller, Matthias, Heuser, Michael
Publicado 2019

D‐2‐hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants

por Pop, Ana, Struys, Eduard A., Jansen, Erwin E. W., Fernandez, Matilde R., Kanhai, Warsha A., van Dooren, Silvy J. M., Ozturk, Senay, van Oostendorp, Justin, Lennertz, Pascal, Kranendijk, Martijn, van der Knaap, Marjo S., Gibson, K. Michael, van Schaftingen, Emile, Salomons, Gajja S.
Publicado 2019

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures

por Verheul, Cassandra, Ntafoulis, Ioannis, Kers, Trisha V, Hoogstrate, Youri, Mastroberardino, Pier G, Barnhoorn, Sander, Payán-Gómez, César, Tching Chi Yen, Romain, Struys, Eduard A, Koolen, Stijn L W, Dirven, Clemens M F, Leenstra, Sieger, French, Pim J, Lamfers, Martine L M
Publicado 2021

Biallelic variants in the SLC13A1 sulfate transporter gene cause hyposulfatemia with a mild spondylo‐epi‐metaphyseal dysplasia

por van de Kamp, Jiddeke M., Bökenkamp, Arend, Smith, Desiree E. C., Wamelink, Mirjam M. C., Jansen, Erwin E. W., Struys, Eduard A., Waisfisz, Quinten, Verkleij, Marieke, Hartmann, Michaela F., Wang, Rong, Wudy, Stefan A., Paganini, Chiara, Rossi, Antonio, Finken, Martijn J. J.
Publicado 2022

Is methotrexate safe for men with an immune-mediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX)

por Perez-Garcia, Luis Fernando, Röder, Esther, Krijthe, Bouwe P, Kranenburg-van Koppen, Laura JC, van Adrichem, Roxanne, Zirkzee, Els, Griffioen, Pieter H, Peeters, Kris, Lin, Marry, Struys, Eduard A, Jansen, Gerrit, van Doorn, Martijn BA, de Jonge, Robert, Dohle, Gert R, Dolhain, Radboud JEM
Publicado 2023

Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer

por Bosch, Sofie, Acharjee, Animesh, Quraishi, Mohammed Nabil, Bijnsdorp, Irene V, Rojas, Patricia, Bakkali, Abdellatif, Jansen, Erwin EW, Stokkers, Pieter, Kuijvenhoven, Johan, Pham, Thang V, Beggs, Andrew D, Jimenez, Connie R, Struys, Eduard A, Gkoutos, Georgios V, de Meij, Tim GJ, de Boer, Nanne KH
Publicado 2022

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

por Suijker, Johnny, Oosting, Jan, Koornneef, Annemarie, Struys, Eduard A., Salomons, Gajja S., Schaap, Frank G., Waaijer, Cathelijn J.F., Wijers-Koster, Pauline M., Briaire-de Bruijn, Inge H., Haazen, Lizette, Riester, Scott M., Dudakovic, Amel, Danen, Erik, Cleton-Jansen, Anne-Marie, van Wijnen, Andre J., Bovée, Judith V.M.G.
Publicado 2015

Blood-based metabolic signatures in Alzheimer's disease

por de Leeuw, Francisca A., Peeters, Carel F.W., Kester, Maartje I., Harms, Amy C., Struys, Eduard A., Hankemeier, Thomas, van Vlijmen, Herman W.T., van der Lee, Sven J., van Duijn, Cornelia M., Scheltens, Philip, Demirkan, Ayşe, van de Wiel, Mark A., van der Flier, Wiesje M., Teunissen, Charlotte E.
Publicado 2017

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency)

por Mills, Philippa B., Footitt, Emma J., Mills, Kevin A., Tuschl, Karin, Aylett, Sarah, Varadkar, Sophia, Hemingway, Cheryl, Marlow, Neil, Rennie, Janet, Baxter, Peter, Dulac, Olivier, Nabbout, Rima, Craigen, William J., Schmitt, Bernhard, Feillet, François, Christensen, Ernst, De Lonlay, Pascale, Pike, Mike G., Hughes, M. Imelda, Struys, Eduard A., Jakobs, Cornelis, Zuberi, Sameer M., Clayton, Peter T.
Publicado 2010

An overview of combined D-2- and L-2-hydroxyglutaric aciduria: functional analysis of CIC variants

por Pop, Ana, Williams, Monique, Struys, Eduard A., Monné, Magnus, Jansen, Erwin E. W., De Grassi, Anna, Kanhai, Warsha A., Scarcia, Pasquale, Ojeda, Matilde R. Fernandez, Porcelli, Vito, van Dooren, Silvy J. M., Lennertz, Pascal, Nota, Benjamin, Abdenur, Jose E., Coman, David, Das, Anibh Martin, El-Gharbawy, Areeg, Nuoffer, Jean-Marc, Polic, Branka, Santer, René, Weinhold, Natalie, Zuccarelli, Britton, Palmieri, Ferdinando, Palmieri, Luigi, Salomons, Gajja S.
Publicado 2017