Sequence-Specific Quantitation of Mutagenic DNA Damage via Polymerase Amplification with an Artificial Nucleotide

por Aloisi, Claudia M. N., Nilforoushan, Arman, Ziegler, Nathalie, Sturla, Shana J.
Publicado 2020

Molecular beacons with oxidized bases report on substrate specificity of DNA oxoguanine glycosylases

por Sun, Jingjing, Antczak, Nicole M., Gahlon, Hailey L., Sturla, Shana J.
Publicado 2022

Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction

por Geigle, Stefanie N., Wyss, Laura A., Sturla, Shana J., Gillingham, Dennis G.
Publicado 2017

DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine

por Stornetta, Alessia, Zimmermann, Maike, Cimino, George D., Henderson, Paul T., Sturla, Shana J.
Publicado 2016

The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O(6)-alkylguanine DNA adducts

por Wyss, Laura A., Nilforoushan, Arman, Williams, David M., Marx, Andreas, Sturla, Shana J.
Publicado 2016

Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses

por Stratenwerth, Björn, Geisen, Susanne M., He, Yang, Beltzig, Lea, Sturla, Shana J., Kaina, Bernd
Publicado 2021

DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A

por Stornetta, Alessia, Villalta, Peter W., Gossner, Frederike, Wilson, William R., Balbo, Silvia, Sturla, Shana J.
Publicado 2017

Mechanism of RNA polymerase II stalling by DNA alkylation

por Malvezzi, Stefano, Farnung, Lucas, Aloisi, Claudia M. N., Angelov, Todor, Cramer, Patrick, Sturla, Shana J.
Publicado 2017

Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation

por Zhang, Jianbo, Lacroix, Christophe, Wortmann, Esther, Ruscheweyh, Hans-Joachim, Sunagawa, Shinichi, Sturla, Shana J., Schwab, Clarissa
Publicado 2019

Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking

por Mingard, Cécile, Battey, James N. D., Takhaveev, Vakil, Blatter, Katharina, Hürlimann, Vera, Sierro, Nicolas, Ivanov, Nikolai V., Sturla, Shana J.
Publicado 2023

Recognition of O(6)-benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction

por Kowal, Ewa A., Lad, Rahul R., Pallan, Pradeep S., Dhummakupt, Elizabeth, Wawrzak, Zdzislaw, Egli, Martin, Sturla, Shana J., Stone, Michael P.
Publicado 2013

Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency

por Zhang, Jianbo, Empl, Michael T., Schwab, Clarissa, Fekry, Mostafa I., Engels, Christina, Schneider, Mirjam, Lacroix, Christophe, Steinberg, Pablo, Sturla, Shana J.
Publicado 2017

In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity

por Müller, Fabrice A., Stamou, Marianna, Englert, Felix H., Frenzel, Ole, Diedrich, Sabine, Suter-Dick, Laura, Wambaugh, John F., Sturla, Shana J.
Publicado 2023

ASH1L-MRG15 methyltransferase deposits H3K4me3 and FACT for damage verification in nucleotide excision repair

por Maritz, Corina, Khaleghi, Reihaneh, Yancoskie, Michelle N., Diethelm, Sarah, Brülisauer, Sonja, Ferreira, Natalia Santos, Jiang, Yang, Sturla, Shana J., Naegeli, Hanspeter
Publicado 2023

Acrolein contributes strongly to antimicrobial and heterocyclic amine transformation activities of reuterin

por Engels, Christina, Schwab, Clarissa, Zhang, Jianbo, Stevens, Marc J. A., Bieri, Corinne, Ebert, Marc-Olivier, McNeill, Kristopher, Sturla, Shana J., Lacroix, Christophe
Publicado 2016

Pathogenic and Commensal Gut Bacteria Harboring Glycerol/Diol Dehydratase Metabolize Glycerol and Produce DNA-Reactive Acrolein

por Ramirez Garcia, Alejandro, Hurley, Katherine, Marastoni, Giovanni, Diard, Médéric, Hofer, Sophie, Greppi, Anna, Hardt, Wolf-Dietrich, Lacroix, Christophe, Sturla, Shana J., Schwab, Clarissa
Publicado 2022

Systems Toxicology: From Basic Research to Risk Assessment

por Sturla, Shana J., Boobis, Alan R., FitzGerald, Rex E., Hoeng, Julia, Kavlock, Robert J., Schirmer, Kristin, Whelan, Maurice, Wilks, Martin F., Peitsch, Manuel C.
Publicado 2014

Systems Toxicology: Real World Applications and Opportunities

por Hartung, Thomas, FitzGerald, Rex E., Jennings, Paul, Mirams, Gary R., Peitsch, Manuel C., Rostami-Hodjegan, Amin, Shah, Imran, Wilks, Martin F., Sturla, Shana J.
Publicado 2017

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

por Crespan, Emmanuele, Furrer, Antonia, Rösinger, Marcel, Bertoletti, Federica, Mentegari, Elisa, Chiapparini, Giulia, Imhof, Ralph, Ziegler, Nathalie, Sturla, Shana J., Hübscher, Ulrich, van Loon, Barbara, Maga, Giovanni
Publicado 2016

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity

por Mentegari, Elisa, Crespan, Emmanuele, Bavagnoli, Laura, Kissova, Miroslava, Bertoletti, Federica, Sabbioneda, Simone, Imhof, Ralph, Sturla, Shana J., Nilforoushan, Arman, Hübscher, Ulrich, van Loon, Barbara, Maga, Giovanni
Publicado 2017