Exploring the Impact of ACE Inhibition in Immunity and Disease

por Oosthuizen, Delia, Sturrock, Edward D.
Publicado 2022

Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis

por Ramasamy, Vinasha, Mayosi, Bongani M, Sturrock, Edward D, Ntsekhe, Mpiko
Publicado 2018

Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

por Masuyer, Geoffrey, Douglas, Ross G., Sturrock, Edward D., Acharya, K. Ravi
Publicado 2015

ACE-domain selectivity extends beyond direct interacting residues at the active site

por Cozier, Gyles E., Lubbe, Lizelle, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2020

Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

por Sharma, Urvashi, Cozier, Gyles E., Sturrock, Edward D., Acharya, K. Ravi
Publicado 2020

Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics

por Cozier, Gyles E., Lubbe, Lizelle, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2020

Cryo‐EM reveals mechanisms of angiotensin I‐converting enzyme allostery and dimerization

por Lubbe, Lizelle, Sewell, Bryan Trevor, Woodward, Jeremy D, Sturrock, Edward D
Publicado 2022

Ace revisited: A new target for structure-based drug design

por Acharya, K. Ravi, Sturrock, Edward D., Riordan, James F., Ehlers, Mario R. W.
Publicado 2003

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

por Lubbe, Lizelle, Cozier, Gyles E., Oosthuizen, Delia, Acharya, K. Ravi, Sturrock, Edward D.
Publicado 2020

Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides

por Masuyer, Geoffrey, Schwager, Sylva L. U., Sturrock, Edward D., Isaac, R. Elwyn, Acharya, K. Ravi
Publicado 2012

Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster

por Akif, Mohd, Masuyer, Geoffrey, Bingham, Richard J, Sturrock, Edward D, Isaac, R Elwyn, Acharya, K Ravi
Publicado 2012

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)

por Yates, Christopher J., Masuyer, Geoffrey, Schwager, Sylva L. U., Akif, Mohd, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2014

Kinetic and structural characterization of amyloid‐β peptide hydrolysis by human angiotensin‐1‐converting enzyme

por Larmuth, Kate M., Masuyer, Geoffrey, Douglas, Ross G., Schwager, Sylva L., Acharya, K. Ravi, Sturrock, Edward D.
Publicado 2016

Crystal structures of sampatrilat and sampatrilat‐Asp in complex with human ACE – a molecular basis for domain selectivity

por Cozier, Gyles E., Schwager, Sylva L., Sharma, Rajni K., Chibale, Kelly, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2018

Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide

por Akif, Mohd, Schwager, Sylva L., Anthony, Colin S., Czarny, Bertrand, Beau, Fabrice, Dive, Vincent, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2011

Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat

por Cozier, Gyles E., Newby, Emma C., Schwager, Sylva L. U., Isaac, R. Elwyn, Sturrock, Edward D., Acharya, K. Ravi
Publicado 2022

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

por Douglas, Ross G., Sharma, Rajni K., Masuyer, Geoffrey, Lubbe, Lizelle, Zamora, Ismael, Acharya, K. Ravi, Chibale, Kelly, Sturrock, Edward D.
Publicado 2013

Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa

por Margolin, Emmanuel, Burgers, Wendy A., Sturrock, Edward D., Mendelson, Marc, Chapman, Rosamund, Douglass, Nicola, Williamson, Anna-Lise, Rybicki, Edward P.
Publicado 2020

The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407

por Anthony, Colin S., Corradi, Hazel R., Schwager, Sylva L. U., Redelinghuys, Pierre, Georgiadis, Dimitris, Dive, Vincent, Acharya, K. Ravi, Sturrock, Edward D.
Publicado 2010

Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril

por Akif, Mohd, Masuyer, Geoffrey, Schwager, Sylva L U, Bhuyan, Bhaskar J, Mugesh, Govindasamy, Isaac, R Elwyn, Sturrock, Edward D, Acharya, K Ravi
Publicado 2011