Randomized trial of tofacitinib in active ulcerative colitis: analysis of efficacy based on patient-reported outcomes

por Panés, Julián, Su, Chinyu, Bushmakin, Andrew G, Cappelleri, Joseph C, Mamolo, Carla, Healey, Paul
Publicado 2015

Exposure–response characterization of tofacitinib efficacy in moderate to severe ulcerative colitis: Results from a dose‐ranging phase 2 trial

por Mukherjee, Arnab, Hazra, Anasuya, Smith, Mike K., Martin, Steven W., Mould, Diane R., Su, Chinyu, Niezychowski, Wojciech
Publicado 2018

Bridging Efficacy of Tofacitinib Immediate‐Release to Extended‐Release Formulations for Treatment of Ulcerative Colitis: Application of a Model‐Informed Drug Development Approach...

por Mukherjee, Arnab, Tsuchiwata, Shinichi, Chang, Cheng, Nicholas, Timothy, Su, Chinyu, Le, Vu H., Kushner, Joseph, Kulisek, Nicole
Publicado 2022

Population Pharmacokinetics of Tofacitinib in Patients With Moderate to Severe Ulcerative Colitis

por Vong, Camille, Martin, Steven W., Deng, Chenhui, Xie, Rujia, Ito, Kaori, Su, Chinyu, Sandborn, William J., Mukherjee, Arnab
Publicado 2021

Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials

por Panaccione, Remo, Isaacs, John D., Chen, Lea Ann, Wang, Wenjin, Marren, Amy, Kwok, Kenneth, Wang, Lisy, Chan, Gary, Su, Chinyu
Publicado 2020

Correction to: Characterization of Creatine Kinase Levels in Tofacitinib‑Treated Patients with Ulcerative Colitis: Results from Clinical Trials

por Panaccione, Remo, Isaacs, John D., Chen, Lea Ann, Wang, Wenjin, Marren, Amy, Kwok, Kenneth, Wang, Lisy, Chan, Gary, Su, Chinyu
Publicado 2020

Exposure‐Response Characterization of Tofacitinib Efficacy in Moderate to Severe Ulcerative Colitis: Results From Phase II and Phase III Induction and Maintenance Studies

por Mukherjee, Arnab, Tsuchiwata, Shinichi, Nicholas, Timothy, Cook, Jack A., Modesto, Irene, Su, Chinyu, D’Haens, Geert R., Sandborn, William J.
Publicado 2022

Modified Mayo score versus Mayo score for evaluation of treatment efficacy in patients with ulcerative colitis: data from the tofacitinib OCTAVE program

por Sandborn, William J., Sands, Bruce E., Vermeire, Séverine, Leung, Yvette, Guo, Xiang, Modesto, Irene, Su, Chinyu, Wang, Wenjin, Panés, Julian
Publicado 2022

Long-Term Improvement in the Patient-Reported Outcomes of Rectal Bleeding, Stool Frequency, and Health-Related Quality of Life with Tofacitinib in the Ulcerative Colitis OCTAVE Cli...

por Hudesman, David P., Torres, Joana, Salese, Leonardo, Woolcott, John C., Mundayat, Rajiv, Su, Chinyu, Mosli, Mahmoud H., Allegretti, Jessica R.
Publicado 2022

The Impact of Raising the Bar for Clinical Trials in Ulcerative Colitis

por Sands, Bruce E, Cheifetz, Adam S, Nduaka, Chudy I, Quirk, Daniel, Wang, Wenjin, Maller, Eric, Friedman, Gary S, Su, Chinyu, Higgins, Peter D R
Publicado 2019

Impact of Concomitant Corticosteroids on Tofacitinib Induction Efficacy and Infection Rates in Ulcerative Colitis

por Lichtenstein, Gary R., Cohen, Benjamin L., Salese, Leonardo, Modesto, Irene, Wang, Wenjin, Chan, Gary, Ahmed, Haytham Mohamed, Su, Chinyu, Peyrin-Biroulet, Laurent
Publicado 2023

Presence of risk factors associated with colectomy among patients with ulcerative colitis: a post hoc analysis of data from the tofacitinib OCTAVE ulcerative colitis clinical progr...

por Rubin, David T., Salese, Leonardo, Cohen, Mitchell, Kotze, Paulo G., Woolcott, John C., Su, Chinyu, Mundayat, Rajiv, Paulissen, Jerome, Torres, Joana, Long, Millie D.
Publicado 2023

Long‐term safety and tolerability of oral tofacitinib in patients with Crohn’s disease: results from a phase 2, open‐label, 48‐week extension study

por Panés, Julián, D’Haens, Geert R., Higgins, Peter D. R., Mele, Linda, Moscariello, Michele, Chan, Gary, Wang, Wenjin, Niezychowski, Wojciech, Su, Chinyu, Maller, Eric
Publicado 2019

Lipid Profiles in Patients With Ulcerative Colitis Receiving Tofacitinib—Implications for Cardiovascular Risk and Patient Management

por Sands, Bruce E, Colombel, Jean-Frédéric, Ha, Christina, Farnier, Michel, Armuzzi, Alessandro, Quirk, Daniel, Friedman, Gary S, Kwok, Kenneth, Salese, Leonardo, Su, Chinyu, Taub, Pam R
Publicado 2020

Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomised RIVETING Trial

por Vermeire, Séverine, Su, Chinyu, Lawendy, Nervin, Kobayashi, Taku, Sandborn, William J, Rubin, David T, Modesto, Irene, Gardiner, Sean, Kulisek, Nicole, Zhang, Haiying, Wang, Wenjin, Panés, Julian
Publicado 2020

Efficacy and Safety of Tofacitinib Re-treatment for Ulcerative Colitis After Treatment Interruption: Results from the OCTAVE Clinical Trials

por Panés, Julian, Vermeire, Séverine, Dubinsky, Marla C, Loftus, Edward V, Lawendy, Nervin, Wang, Wenjin, Salese, Leonardo, Su, Chinyu, Modesto, Irene, Guo, Xiang, Colombel, Jean-Frederic
Publicado 2021

Clostridium difficile Infection in Patients with Ulcerative Colitis Treated with Tofacitinib in the Ulcerative Colitis Program

por Loftus, Edward V, Baumgart, Daniel C, Gecse, Krisztina, Kinnucan, Jami A, Connelly, Susan B, Salese, Leonardo, Su, Chinyu, Kwok, Kenneth K, Woolcott, John C, Armuzzi, Alessandro
Publicado 2022

Herpes Zoster Infection in Patients With Ulcerative Colitis Receiving Tofacitinib

por Winthrop, Kevin L, Melmed, Gil Y, Vermeire, Séverine, Long, Millie D, Chan, Gary, Pedersen, Ronald D, Lawendy, Nervin, Thorpe, Andrew J, Nduaka, Chudy I, Su, Chinyu
Publicado 2018

Assessment of Safety and Efficacy of Tofacitinib, Stratified by Age, in Patients from the Ulcerative Colitis Clinical Program

por Lichtenstein, Gary R, Bressler, Brian, Francisconi, Carlos, Vermeire, Severine, Lawendy, Nervin, Salese, Leonardo, Sawyerr, Gosford, Shi, Hongjiong, Su, Chinyu, Judd, Donna T, Jones, Thomas, Loftus, Edward V
Publicado 2022

Venous thromboembolic events in the tofacitinib ulcerative colitis clinical development programme

por Sandborn, William J., Panés, Julian, Sands, Bruce E., Reinisch, Walter, Su, Chinyu, Lawendy, Nervin, Koram, Nana, Fan, Haiyun, Jones, Thomas V., Modesto, Irene, Quirk, Daniel, Danese, Silvio
Publicado 2019