Discovery and Structure–Activity Relationship Studies of Novel Adenosine A(1) Receptor-Selective Agonists

por Preti, Barbara, Suchankova, Anna, Deganutti, Giuseppe, Leuenberger, Michele, Barkan, Kerry, Manulak, Iga, Huang, Xianglin, Carvalho, Sabrina, Ladds, Graham, Lochner, Martin
Publicado 2022

Discovery of a High Affinity Adenosine A(1)/A(3) Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold

por Suchankova, Anna, Stampelou, Margarita, Koutsouki, Klontiana, Pousias, Athanasios, Dhingra, Lakshiv, Barkan, Kerry, Pouli, Nicole, Marakos, Panagiotis, Tenta, Roxane, Kolocouris, Antonios, Lougiakis, Nikolaos, Ladds, Graham
Publicado 2022

Selective activation of Gαob by an adenosine A(1) receptor agonist elicits analgesia without cardiorespiratory depression

por Wall, Mark J., Hill, Emily, Huckstepp, Robert, Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue, Spanswick, David, Reynolds, Christopher A., Lochner, Martin, Ladds, Graham, Frenguelli, Bruno G.
Publicado 2022