Multitargeted anti-infective drugs: resilience to resistance in the antimicrobial resistance era

por Suckling, Colin J, Hunter, Iain S, Scott, Fraser J
Publicado 2022

2,2,2-Trifluoro-N-(isoquinolin-5-ylmeth­yl)acetamide

por Kennedy, Alan R., Khalaf, Abedawn I., Suckling, Colin J.
Publicado 2009

Novel TPP-riboswitch activators bypass metabolic enzyme dependency

por Lünse, Christina E., Scott, Fraser J., Suckling, Colin J., Mayer, Günter
Publicado 2014

Crystal structure of N,N-dimethyl-2-[(4-methyl­benz­yl)sulfon­yl]ethanamine

por Kennedy, Alan R., Khalaf, Abedawn I., Scott, Fraser J., Suckling, Colin J.
Publicado 2015

Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders

por Kennedy, Alan R., Khalaf, Abedawn I., Scott, Fraser J., Suckling, Colin J.
Publicado 2017

Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

por Suckling, Colin J., Alam, Shahabuddin, Olson, Mark A., Saikh, Kamal U., Harnett, Margaret M., Harnett, William
Publicado 2018

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

por Baiget, Jessica, Llona-Minguez, Sabin, Lang, Stuart, MacKay, Simon P, Suckling, Colin J, Sutcliffe, Oliver B
Publicado 2011

Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

por Chreifi, Georges, Li, Huiying, McInnes, Craig R., Gibson, Colin L., Suckling, Colin J., Poulos, Thomas L.
Publicado 2014

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

por Al-Riyami, Lamyaa, Rodgers, David T., Rzepecka, Justyna, Pineda, Miguel A., Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado 2015

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

por Lumb, Felicity E., Doonan, James, Bell, Kara S., Pineda, Miguel A., Corbet, Marlene, Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado 2017

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

por Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Publicado 2016

Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis

por Doonan, James, Lumb, Felicity E., Pineda, Miguel A., Tarafdar, Anuradha, Crowe, Jenny, Khan, Aneesah M., Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado 2018

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

por Corbet, Marlene, Pineda, Miguel A., Yang, Kun, Tarafdar, Anuradha, McGrath, Sarah, Nakagawa, Rinako, Lumb, Felicity E., Suckling, Colin J., Harnett, William, Harnett, Margaret M.
Publicado 2021

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

por Tulloch, Lindsay B., Martini, Viviane P., Iulek, Jorge, Huggan, Judith K., Lee, Jeong Hwan, Gibson, Colin L., Smith, Terry K., Suckling, Colin J., Hunter, William N.
Publicado 2009

Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced A...

por Al-Riyami, Lamyaa, Pineda, Miguel A., Rzepecka, Justyna, Huggan, Judith K., Khalaf, Abedawn I., Suckling, Colin J., Scott, Fraser J., Rodgers, David T., Harnett, Margaret M., Harnett, William
Publicado 2013

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

por Khalaf, Abedawn I., Huggan, Judith K., Suckling, Colin J., Gibson, Colin L., Stewart, Kirsten, Giordani, Federica, Barrett, Michael P., Wong, Pui Ee, Barrack, Keri L., Hunter, William N.
Publicado 2014

The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing

por Harnett, Margaret M., Doonan, James, Lumb, Felicity E., Crowe, Jenny, Damink, Roel Olde, Buitrago, Geraldine, Duncombe-Moore, Josephine, Wilkinson, Debbie I., Suckling, Colin J., Selman, Colin, Harnett, William
Publicado 2022

Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification

por Perieteanu, Marina C., McGee, Leah M. C., Shaw, Craig D., MacMillan, Donna S., Khalaf, Abedawn I., Gillingwater, Kirsten, Beveridge, Rebecca, Carter, Katharine C., Suckling, Colin J., Scott, Fraser J.
Publicado 2022

Ratiometric imaging of minor groove binders in mammalian cells using Raman microscopy

por Tentellino, Christian, Tipping, William J., McGee, Leah M. C., Bain, Laura M., Wetherill, Corinna, Laing, Stacey, Tyson-Hirst, Izaak, Suckling, Colin J., Beveridge, Rebecca, Scott, Fraser J., Faulds, Karen, Graham, Duncan
Publicado 2022

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

por Rzepecka, Justyna, Coates, Michelle L., Saggar, Moninder, Al-Riyami, Lamyaa, Coltherd, Jennifer, Tay, Hwee Kee, Huggan, Judith K., Janicova, Lucia, Khalaf, Abedawn I., Siebeke, Ivonne, Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado 2014