Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8(+) T cell activation

por Hibino, Sana, Eto, Shotaro, Hangai, Sho, Endo, Keiko, Ashitani, Sanae, Sugaya, Maki, Osawa, Tsuyoshi, Soga, Tomoyoshi, Taniguchi, Tadatsugu, Yanai, Hideyuki
Publicado 2023

Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils

por Kato, Miki, Maeda, Keisuke, Nakahara, Ryuichi, Hirose, Haruka, Kondo, Ayano, Aki, Sho, Sugaya, Maki, Hibino, Sana, Nishida, Miyuki, Hasegawa, Manami, Morita, Hinano, Ando, Ritsuko, Tsuchida, Rika, Yoshida, Minoru, Kodama, Tatsuhiko, Yanai, Hideyuki, Shimamura, Teppei, Osawa, Tsuyoshi
Publicado 2023

Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors

por Pan, Melvin, Zorbas, Christiane, Sugaya, Maki, Ishiguro, Kensuke, Kato, Miki, Nishida, Miyuki, Zhang, Hai-Feng, Candeias, Marco M., Okamoto, Akimitsu, Ishikawa, Takamasa, Soga, Tomoyoshi, Aburatani, Hiroyuki, Sakai, Juro, Matsumura, Yoshihiro, Suzuki, Tsutomu, Proud, Christopher G., Lafontaine, Denis L. J., Osawa, Tsuyoshi
Publicado 2022

Hypoxia activates SREBP2 through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth

por Nakahara, Ryuichi, Aki, Sho, Sugaya, Maki, Hirose, Haruka, Kato, Miki, Maeda, Keisuke, Sakamoto, Daichi M, Kojima, Yasuhiro, Nishida, Miyuki, Ando, Ritsuko, Muramatsu, Masashi, Pan, Melvin, Tsuchida, Rika, Matsumura, Yoshihiro, Yanai, Hideyuki, Takano, Hiroshi, Yao, Ryoji, Sando, Shinsuke, Shibuya, Masabumi, Sakai, Juro, Kodama, Tatsuhiko, Kidoya, Hiroyasu, Shimamura, Teppei, Osawa, Tsuyoshi
Publicado 2023

Exome-wide Association Study Identifies CLEC3B Missense Variant p.S106G as Being Associated With Extreme Longevity in East Asian Populations

por Tanisawa, Kumpei, Arai, Yasumichi, Hirose, Nobuyoshi, Shimokata, Hiroshi, Yamada, Yoshiji, Kawai, Hisashi, Kojima, Motonaga, Obuchi, Shuichi, Hirano, Hirohiko, Yoshida, Hideyo, Suzuki, Hiroyuki, Fujiwara, Yoshinori, Ihara, Kazushige, Sugaya, Maki, Arai, Tomio, Mori, Seijiro, Sawabe, Motoji, Sato, Noriko, Muramatsu, Masaaki, Higuchi, Mitsuru, Liu, Yao-Wen, Kong, Qing-Peng, Tanaka, Masashi
Publicado 2017

Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma

por Kitagawa, Akihiro, Osawa, Tsuyoshi, Noda, Miwa, Kobayashi, Yuta, Aki, Sho, Nakano, Yusuke, Saito, Tomoko, Shimizu, Dai, Komatsu, Hisateru, Sugaya, Maki, Takahashi, Junichi, Kosai, Keisuke, Takao, Seiichiro, Motomura, Yushi, Sato, Kuniaki, Hu, Qingjiang, Fujii, Atsushi, Wakiyama, Hiroaki, Tobo, Taro, Uchida, Hiroki, Sugimachi, Keishi, Shibata, Kohei, Utsunomiya, Tohru, Kobayashi, Shogo, Ishii, Hideshi, Hasegawa, Takanori, Masuda, Takaaki, Matsui, Yusuke, Niida, Atsushi, Soga, Tomoyoshi, Suzuki, Yutaka, Miyano, Satoru, Aburatani, Hiroyuki, Doki, Yuichiro, Eguchi, Hidetoshi, Mori, Masaki, Nakayama, Keiichi I., Shimamura, Teppei, Shibata, Tatsuhiro, Mimori, Koshi
Publicado 2023