The insulin receptor family in the heart: new light on old insights

por Clerk, Angela, Sugden, Peter H.
Publicado 2022

Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein–coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A R...

por Clerk, Angela, Michael, Ashour, Sugden, Peter H.
Publicado 1998

p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic r...

por Amirak, Emre, Fuller, Stephen J., Sugden, Peter H., Clerk, Angela
Publicado 2013

ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes

por Marshall, Andrew K., Barrett, Oliver P. T., Cullingford, Timothy E., Shanmugasundram, Achchuthan, Sugden, Peter H., Clerk, Angela
Publicado 2010

Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin

por Markou, Thomais, Marshall, Andrew K, Cullingford, Timothy E, Tham, El L, Sugden, Peter H, Clerk, Angela
Publicado 2010

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: Effects of endothelin-1, oxidative stress and cytokines

por Cullingford, Timothy E., Butler, Matthew J., Marshall, Andrew K., Tham, El Li, Sugden, Peter H., Clerk, Angela
Publicado 2008

Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active

por Sugden, Peter H., Markou, Thomais, Fuller, Stephen J., Tham, El Li, Molkentin, Jeffery D., Paterson, Hugh F., Clerk, Angela
Publicado 2011

A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

por Fuller, Stephen J., McGuffin, Liam J., Marshall, Andrew K., Giraldo, Alejandro, Pikkarainen, Sampsa, Clerk, Angela, Sugden, Peter H.
Publicado 2012

Corrigendum to “Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active” [Cell Sig...

por Sugden, Peter H., Markou, Thomais, Fuller, Stephen J., Tham, El Li, Molkentin, Jeffery D., Paterson, Hugh F., Clerk, Angela
Publicado 2011

Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target

por Giraldo, Alejandro, Barrett, Oliver P. T., Tindall, Marcus J., Fuller, Stephen J., Amirak, Emre, Bhattacharya, Bonhi S., Sugden, Peter H., Clerk, Angela
Publicado 2012

The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α(1)-adrenergic receptors

por Meijles, Daniel N., Fuller, Stephen J., Cull, Joshua J., Alharbi, Hajed O., Cooper, Susanna T.E., Sugden, Peter H., Clerk, Angela
Publicado 2021

The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

por Meijles, Daniel N., Zoumpoulidou, Georgia, Markou, Thomais, Rostron, Kerry A., Patel, Rishi, Lay, Kenneth, Handa, Balvinder S., Wong, Bethany, Sugden, Peter H., Clerk, Angela
Publicado 2019

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

por Fuller, Stephen J., Edmunds, Nick S., McGuffin, Liam J., Hardyman, Michelle A., Cull, Joshua J., Alharbi, Hajed O., Meijles, Daniel N., Sugden, Peter H., Clerk, Angela
Publicado 2021

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

por Alharbi, Hajed O., Hardyman, Michelle A., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Glennon, Peter E., Fuller, Stephen J., Sugden, Peter H., Clerk, Angela
Publicado 2022

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes

por Cullingford, Timothy E, Markou, Thomais, Fuller, Stephen J, Giraldo, Alejandro, Pikkarainen, Sampsa, Zoumpoulidou, Georgia, Alsafi, Ali, Ekere, Collins, Kemp, Timothy J, Dennis, Jayne L, Game, Laurence, Sugden, Peter H, Clerk, Angela
Publicado 2008

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

por Meijles, Daniel N., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Haines, Zoe H.R., Fuller, Stephen J., O’Gara, Peter, Sheppard, Mary N., Harding, Sian E., Sugden, Peter H., Clerk, Angela
Publicado 2020

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

por Meijles, Daniel N., Cull, Joshua J., Cooper, Susanna T.E., Markou, Thomais, Hardyman, Michelle A., Fuller, Stephen J., Alharbi, Hajed O., Haines, Zoe H.R., Alcantara-Alonso, Viridiana, Glennon, Peter E., Sheppard, Mary N., Sugden, Peter H., Clerk, Angela
Publicado 2021

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

por Clerk, Angela, Meijles, Daniel N., Hardyman, Michelle A., Fuller, Stephen J., Chothani, Sonia P., Cull, Joshua J., Cooper, Susanna T.E., Alharbi, Hajed O., Vanezis, Konstantinos, Felkin, Leanne E., Markou, Thomais, Leonard, Samuel J., Shaw, Spencer W., Rackham, Owen J.L., Cook, Stuart A., Glennon, Peter E., Sheppard, Mary N., Sembrat, John C., Rojas, Mauricio, McTiernan, Charles F., Barton, Paul J., Sugden, Peter H.
Publicado 2022