Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

por Tsunekawa, Taku, Banno, Ryoichi, Mizoguchi, Akira, Sugiyama, Mariko, Tominaga, Takashi, Onoue, Takeshi, Hagiwara, Daisuke, Ito, Yoshihiro, Iwama, Shintaro, Goto, Motomitsu, Suga, Hidetaka, Sugimura, Yoshihisa, Arima, Hiroshi
Publicado 2017

GABA(B) Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet

por Tsunekawa, Taku, Banno, Ryoichi, Yaginuma, Hiroshi, Taki, Keigo, Mizoguchi, Akira, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Iwama, Shintaro, Goto, Motomitsu, Suga, Hidetaka, Bettler, Bernhard, Arima, Hiroshi
Publicado 2019

Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice

por Kawaguchi, Yohei, Hagiwara, Daisuke, Miyata, Takashi, Hodai, Yuichi, Kurimoto, Junki, Takagi, Hiroshi, Suga, Hidetaka, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Ito, Yoshihiro, Iwama, Shintaro, Banno, Ryoichi, Grinevich, Valery, Arima, Hiroshi
Publicado 2020

Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice

por Ito, Masaaki, Iwama, Shintaro, Sugiyama, Daisuke, Yasuda, Yoshinori, Okuji, Takayuki, Kobayashi, Tomoko, Zhou, Xin, Yamagami, Ayana, Onoue, Takeshi, Miyata, Takashi, Sugiyama, Mariko, Hagiwara, Daisuke, Suga, Hidetaka, Banno, Ryoichi, Nishikawa, Hiroyoshi, Arima, Hiroshi
Publicado 2023

Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors

por Kobayashi, Tomoko, Iwama, Shintaro, Sugiyama, Daisuke, Yasuda, Yoshinori, Okuji, Takayuki, Ito, Masaaki, Ito, Sachiko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Nishikawa, Hiroyoshi, Arima, Hiroshi
Publicado 2021

Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating

por Sun, Runan, Sugiyama, Mariko, Wang, Sixian, Kuno, Mitsuhiro, Sasaki, Tomoyuki, Hirose, Tomonori, Miyata, Takashi, Kobayashi, Tomoko, Tsunekawa, Taku, Onoue, Takeshi, Yasuda, Yoshinori, Takagi, Hiroshi, Hagiwara, Daisuke, Iwama, Shintaro, Suga, Hidetaka, Arima, Hiroshi
Publicado 2022

A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients

por Kojima, Hajime, Nakada, Tokio, Yagami, Akiko, Todo, Hiroaki, Nishimura, Jihei, Yagi, Mio, Yamamoto, Keiko, Sugiyama, Mariko, Ikarashi, Yoshiaki, Sakaguchi, Hitoshi, Yamaguchi, Masahiko, Hirota, Morihiko, Aizawa, Sakiko, Nakagawa, Shota, Hagino, Shigenobu, Hatao, Masato
Publicado 2022

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice

por Mizoguchi, Akira, Banno, Ryoichi, Sun, Runan, Yaginuma, Hiroshi, Taki, Keigo, Kobayashi, Tomoko, Sugiyama, Mariko, Tsunekawa, Taku, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Iwama, Shintaro, Suga, Hidetaka, Nagai, Taku, Yamada, Kiyofumi, Arima, Hiroshi
Publicado 2021

Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin

por Ito, Yoshihiro, Sun, Runan, Yagimuma, Hiroshi, Taki, Keigo, Mizoguchi, Akira, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Tsunekawa, Taku, Takagi, Hiroshi, Hagiwara, Daisuke, Iwama, Shintaro, Suga, Hidetaka, Konishi, Hiroyuki, Kiyama, Hiroshi, Arima, Hiroshi, Banno, Ryoichi
Publicado 2022

Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study

por Handa, Tomoko, Onoue, Takeshi, Kobayashi, Tomoko, Wada, Eri, Hayase, Ayaka, Kinoshita, Tamaki, Yamagami, Ayana, Yasuda, Yoshinori, Iwama, Shintaro, Kawaguchi, Yohei, Miyata, Takashi, Sugiyama, Mariko, Takagi, Hiroshi, Hagiwara, Daisuke, Suga, Hidetaka, Banno, Ryoichi, Goto, Motomitsu, Arima, Hiroshi
Publicado 2022

Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet

por Taki, Keigo, Takagi, Hiroshi, Hirose, Tomonori, Sun, Runan, Yaginuma, Hiroshi, Mizoguchi, Akira, Kobayashi, Tomoko, Sugiyama, Mariko, Tsunekawa, Taku, Onoue, Takeshi, Hagiwara, Daisuke, Ito, Yoshihiro, Iwama, Shintaro, Suga, Hidetaka, Banno, Ryoichi, Sakano, Daisuke, Kume, Shoen, Arima, Hiroshi
Publicado 2021

GABA(B) receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice

por Sun, Runan, Tsunekawa, Taku, Hirose, Tomonori, Yaginuma, Hiroshi, Taki, Keigo, Mizoguchi, Akira, Miyata, Takashi, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Iwama, Shintaro, Suga, Hidetaka, Banno, Ryoichi, Bettler, Bernhard, Arima, Hiroshi
Publicado 2021

Generation of hypothalamic neural stem cell-like cells in vitro from human pluripotent stem cells

por Miwata, Tsutomu, Suga, Hidetaka, Kawaguchi, Yohei, Sakakibara, Mayu, Kano, Mayuko, Taga, Shiori, Soen, Mika, Ozaki, Hajime, Asano, Tomoyoshi, Sasaki, Hiroo, Miyata, Takashi, Yasuda, Yoshinori, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Iwama, Shintaro, Arima, Hiroshi
Publicado 2023

Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled trial

por Onoue, Takeshi, Goto, Motomitsu, Wada, Eri, Furukawa, Mariko, Okuji, Takayuki, Okada, Norio, Kobayashi, Tomoko, Iwama, Shintaro, Sugiyama, Mariko, Tsunekawa, Taku, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Morishita, Yoshiaki, Seino, Yusuke, Suga, Hidetaka, Banno, Ryoichi, Hamada, Yoji, Ando, Masahiko, Yamamori, Etsuko, Arima, Hiroshi
Publicado 2020

SAT-648 Flash Glucose Monitoring Helps Achieve Better Glycemic Control Than Conventional Self-Monitoring of Blood Glucose in Non-Insulin-Treated Type 2 Diabetes: A Randomized Contr...

por Wada, Eri, Onoue, Takeshi, Kobayashi, Tomoko, Handa, Tomoko, Hayase, Ayaka, Ito, Masaaki, Furukawa, Mariko, Okuji, Takayuki, Okada, Norio, Iwama, Shintaro, Sugiyama, Mariko, Tsunekawa, Taku, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Kuwatsuka, Yachiyo, Ando, Masahiko, Goto, Motomitsu, Arima, Hiroshi
Publicado 2020

Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled tr...

por Wada, Eri, Onoue, Takeshi, Kobayashi, Tomoko, Handa, Tomoko, Hayase, Ayaka, Ito, Masaaki, Furukawa, Mariko, Okuji, Takayuki, Okada, Norio, Iwama, Shintaro, Sugiyama, Mariko, Tsunekawa, Taku, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Kuwatsuka, Yachiyo, Ando, Masahiko, Goto, Motomitsu, Arima, Hiroshi
Publicado 2020

Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

por Miyata, Takashi, Hagiwara, Daisuke, Hodai, Yuichi, Miwata, Tsutomu, Kawaguchi, Yohei, Kurimoto, Junki, Ozaki, Hajime, Mitsumoto, Kazuki, Takagi, Hiroshi, Suga, Hidetaka, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Ito, Yoshihiro, Iwama, Shintaro, Banno, Ryoichi, Matsumoto, Mami, Kawakami, Natsuko, Ohno, Nobuhiko, Sakamoto, Hirotaka, Arima, Hiroshi
Publicado 2020

Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state

por Ozaki, Hajime, Suga, Hidetaka, Sakakibara, Mayu, Soen, Mika, Miyake, Natsuki, Miwata, Tsutomu, Taga, Shiori, Nagai, Takashi, Kano, Mayuko, Mitsumoto, Kazuki, Miyata, Takashi, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Iwama, Shintaro, Banno, Ryoichi, Iguchi, Genzo, Takahashi, Yutaka, Muguruma, Keiko, Inoue, Haruhisa, Arima, Hiroshi
Publicado 2022

Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective...

por Kobayashi, Tomoko, Iwama, Shintaro, Yasuda, Yoshinori, Okada, Norio, Okuji, Takayuki, Ito, Masaaki, Onoue, Takeshi, Goto, Motomitsu, Sugiyama, Mariko, Tsunekawa, Taku, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Yokota, Kenji, Hase, Tetsunari, Morise, Masahiro, Hashimoto, Naozumi, Ando, Masahiko, Fujimoto, Yasushi, Hibi, Hideharu, Sone, Michihiko, Ando, Yuichi, Akiyama, Masashi, Hasegawa, Yoshinori, Arima, Hiroshi
Publicado 2020

Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation

por Taga, Shiori, Suga, Hidetaka, Nakano, Tokushige, Kuwahara, Atsushi, Inoshita, Naoko, Kodani, Yu, Nagasaki, Hiroshi, Sato, Yoshitaka, Tsumura, Yusuke, Sakakibara, Mayu, Soen, Mika, Miwata, Tsutomu, Ozaki, Hajime, Kano, Mayuko, Watari, Kenji, Ikeda, Atsushi, Yamanaka, Mitsugu, Takahashi, Yasuhiko, Kitamoto, Sachiko, Kawaguchi, Yohei, Miyata, Takashi, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Yasuda, Yoshinori, Hagiwara, Daisuke, Iwama, Shintaro, Tomigahara, Yoshitaka, Kimura, Toru, Arima, Hiroshi
Publicado 2023