A case of perforation of the prostatic abscess into the rectum resulting in a rectoprostatic fistula

por Sugiyama, Yuichi, Fujikawa, Atsushi, Yokokawa, Shuhei
Publicado 2023

Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the E...

por Toshimoto, Kota, Tomaru, Atsuko, Hosokawa, Masakiyo, Sugiyama, Yuichi
Publicado 2017

Differences in Substrate Specificity among Glutathione Conjugates (GS‐X) Pump Family Members: Comparison between Multidrug Resistance‐associated Protein and a Novel Transporter Exp...

por Ueda, Kaoru, Suzuki, Hiroshi, Akiyama, Shin‐ichi, Sugiyama, Yuichi
Publicado 1999

Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B

por Nakayama, Shinji, Toshimoto, Kota, Yamazaki, Shinji, Snoeys, Jan, Sugiyama, Yuichi
Publicado 2023

Robust physiologically based pharmacokinetic model of rifampicin for predicting drug–drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidn...

por Asaumi, Ryuta, Nunoya, Ken‐ichi, Yamaura, Yoshiyuki, Taskar, Kunal S., Sugiyama, Yuichi
Publicado 2022

Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

por Nishiyama, Kotaro, Toshimoto, Kota, Lee, Wooin, Ishiguro, Naoki, Bister, Bojan, Sugiyama, Yuichi
Publicado 2019

Assessment of statin-associated muscle toxicity in Japan: a cohort study conducted using claims database and laboratory information

por Chang, Chia-Hsien, Kusama, Makiko, Ono, Shunsuke, Sugiyama, Yuichi, Orii, Takao, Akazawa, Manabu
Publicado 2013

Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype‐Guided Dosing of Tamoxifen

por Nakamura, Toshimichi, Toshimoto, Kota, Lee, Wooin, Imamura, Chiyo K., Tanigawara, Yusuke, Sugiyama, Yuichi
Publicado 2018

Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion...

por Asaumi, Ryuta, Menzel, Karsten, Lee, Wooin, Nunoya, Ken‐ichi, Imawaka, Haruo, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Publicado 2019

Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies

por Yoshikado, Takashi, Aoki, Yasunori, Mochizuki, Tatsuki, Rodrigues, A. David, Chiba, Koji, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Publicado 2022

Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

por Asaumi, Ryuta, Toshimoto, Kota, Tobe, Yoshifusa, Hashizume, Kenta, Nunoya, Ken‐ichi, Imawaka, Haruo, Lee, Wooin, Sugiyama, Yuichi
Publicado 2018

PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

por Yoshikado, Takashi, Toshimoto, Kota, Maeda, Kazuya, Kusuhara, Hiroyuki, Kimoto, Emi, Rodrigues, A. David, Chiba, Koji, Sugiyama, Yuichi
Publicado 2018

In vivo Cisplatin Resistance Depending upon Canalicular Multispecific Organic Anion Transporter (cMOAT)

por Minamino, Tomoyoshi, Tamai, Mitsuo, Itoh, Yoshie, Tatsumi, Yasuaki, Nomura, Masaaki, Yokogawa, Koichi, Suzuki, Hiroshi, Sugiyama, Yuichi, Ohshima, Tohru, Miyamoto, Ken‐ichi
Publicado 1999

Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functi...

por Lee, Wooin, Koyama, Satoshi, Morita, Kiyoe, Kiriake, Aya, Kikuchi, Ryota, Chu, Xiaoyan, Lee, Nora, Scialis, Renato J., Shen, Hong, Kimoto, Emi, Tremaine, Larry, Ishiguro, Naoki, Lotz, Ralf, Maeda, Kazuya, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Publicado 2020

Evaluation of [(11)C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey...

por Seki, Chie, Oh-Nishi, Arata, Nagai, Yuji, Minamimoto, Takafumi, Obayashi, Shigeru, Higuchi, Makoto, Takei, Makoto, Furutsuka, Kenji, Ito, Takehito, Zhang, Ming-Rong, Ito, Hiroshi, Ito, Mototsugu, Ito, Sumito, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Suhara, Tetsuya
Publicado 2014

Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs

por Mori, Daiki, Kimoto, Emi, Rago, Brian, Kondo, Yusuke, King‐Ahmad, Amanda, Ramanathan, Ragu, Wood, Linda S., Johnson, Jillian G., Le, Vu H., Vourvahis, Manoli, David Rodrigues, A., Muto, Chieko, Furihata, Kenichi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Publicado 2020

Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein‐Mediated Drug‐Drug Interactions in Healthy Volunteers

por Miyake, Takeshi, Kimoto, Emi, Luo, Lina, Mathialagan, Sumathy, Horlbogen, Lauren M., Ramanathan, Ragu, Wood, Linda S., Johnson, Jillian G., Le, Vu H., Vourvahis, Manoli, Rodrigues, A. David, Muto, Chieko, Furihata, Kenichi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Publicado 2020

Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs

por Mochizuki, Tatsuki, Aoki, Yasunori, Yoshikado, Takashi, Yoshida, Kenta, Lai, Yurong, Hirabayashi, Hideki, Yamaura, Yoshiyuki, Rockich, Kevin, Taskar, Kunal, Takashima, Tadayuki, Chu, Xiaoyan, Zamek‐Gliszczynski, Maciej J., Mao, Jialin, Maeda, Kazuya, Furihata, Kenichi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Publicado 2022

Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions

por Mochizuki, Tatsuki, Zamek‐Gliszczynski, Maciej J., Yoshida, Kenta, Mao, Jialin, Taskar, Kunal, Hirabayashi, Hideki, Chu, Xiaoyan, Lai, Yurong, Takashima, Tadayuki, Rockich, Kevin, Yamaura, Yoshiyuki, Fujiwara, Kaku, Mizuno, Tadahaya, Maeda, Kazuya, Furihata, Kenichi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Publicado 2022

Report on the use of non‐clinical studies in the regulatory evaluation of oncology drugs

por Hayakawa, Yoshihiro, Kawada, Manabu, Nishikawa, Hiroyoshi, Ochiya, Takahiro, Saya, Hideyuki, Seimiya, Hiroyuki, Yao, Ryoji, Hayashi, Masahiro, Kai, Chieko, Matsuda, Akira, Naoe, Tomoki, Ohtsu, Atsushi, Okazaki, Taku, Saji, Hideo, Sata, Masataka, Sugimura, Haruhiko, Sugiyama, Yuichi, Toi, Masakazu, Irimura, Tatsuro
Publicado 2016