Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

por Ayyar, Vivaswath S., Sukumaran, Siddharth
Publicado 2021

Meta-Modeling of Methylprednisolone Effects on Glucose Regulation in Rats

por Fang, Jing, Sukumaran, Siddharth, DuBois, Debra C., Almon, Richard R., Jusko, William J.
Publicado 2013

gPKPDSim: a SimBiology(®)-based GUI application for PKPD modeling in drug development

por Hosseini, Iraj, Gajjala, Anita, Bumbaca Yadav, Daniela, Sukumaran, Siddharth, Ramanujan, Saroja, Paxson, Ricardo, Gadkar, Kapil
Publicado 2018

Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats

por Xue, Bai, Sukumaran, Siddharth, Nie, Jing, Jusko, William J., DuBois, Debra C., Almon, Richard R.
Publicado 2011

Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals

por Wang, Xi, DuBois, Debra C, Sukumaran, Siddharth, Ayyar, Vivaswath, Jusko, William J, Almon, Richard R
Publicado 2014

Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration

por Nguyen, Tung T, Almon, Richard R, DuBois, Debra C, Sukumaran, Siddharth, Jusko, William J, Androulakis, Ioannis P
Publicado 2014

Circadian signatures in rat liver: from gene expression to pathways

por Ovacik, Meric A, Sukumaran, Siddharth, Almon, Richard R, DuBois, Debra C, Jusko, William J, Androulakis, Ioannis P
Publicado 2010

Effects of High Fat Feeding on Liver Gene Expression in Diabetic Goto-Kakizaki Rats

por Almon, Richard R., DuBois, Debra C., Sukumaran, Siddharth, Wang, Xi, Xue, Bai, Nie, Jing, Jusko, William J.
Publicado 2012

A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab‐Treated non‐small Cell Lung Cancer Patients

por Netterberg, Ida, Li, Chi‐Chung, Molinero, Luciana, Budha, Nageshwar, Sukumaran, Siddharth, Stroh, Mark, Jonsson, E. Niclas, Friberg, Lena E.
Publicado 2018

A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma

por Rymut, Sharon M., Henderson, Lindsay M., Poon, Victor, Staton, Tracy L., Cai, Fang, Sukumaran, Siddharth, Rhee, Horace, Owen, Ryan, Ramanujan, Saroja, Yoshida, Kenta
Publicado 2023

Highly Multiplexed and Reproducible Ion-Current-Based Strategy for Large-Scale Quantitative Proteomics and the Application to Protein Expression Dynamics Induced by Methylprednisol...

por Nouri-Nigjeh, Eslam, Sukumaran, Siddharth, Tu, Chengjian, Li, Jun, Shen, Xiaomeng, Duan, Xiaotao, DuBois, Debra C., Almon, Richard R., Jusko, William J., Qu, Jun
Publicado 2014

Integrated systems modeling of severe asthma: Exploration of IL‐33/ST2 antagonism

por Gadkar, Kapil, Feigelman, Justin, Sukumaran, Siddharth, Rodrigo, Manoj C., Staton, Tracy, Cai, Fang, Bauer, Rebecca N., Choy, David F., Stokes, Cynthia L., Scheerens, Heleen, Ramanujan, Saroja
Publicado 2022

Nonclinical safety assessment of a human interleukin‐22FC IG fusion protein demonstrates in vitro to in vivo and cross‐species translatability

por Lee, Donna W., Zhong, Shelly, Pai, Rama, Rae, Julie, Sukumaran, Siddharth, Stefanich, Eric G., Lutman, Jeff, Doudement, Estelle, Wang, Xiaoting, Harder, Brandon, Lekkerkerker, Annemarie, Herman, Ann, Ouyang, Wenjun, Danilenko, Dimitry M.
Publicado 2018

Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial

por Rymut, Sharon M., Sukumaran, Siddharth, Sperinde, Gizette, Bremer, Meire, Galanter, Joshua, Yoshida, Kenta, Smith, Jordan, Banerjee, Prajna, Sverkos, Viyia, Cai, Fang, Steffen, Verena, Henderson, Lindsay M., Rhee, Horace, Belloni, Paula N., Lin, Joseph H., Staton, Tracy L.
Publicado 2021

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

por Chung, Shan, Nguyen, Van, Lin, Yuwen Linda, Lafrance-Vanasse, Julien, Scales, Suzie J., Lin, Kevin, Deng, Rong, Williams, Kathi, Sperinde, Gizette, Li, Juan Jenny, Zheng, Kai, Sukumaran, Siddharth, Tesar, Devin, Ernst, James A., Fischer, Saloumeh, Lazar, Greg A., Prabhu, Saileta, Song, An
Publicado 2019

Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent...

por Yadav, Rajbharan, Sukumaran, Siddharth, Zabka, Tanja S., Li, Jinze, Oldendorp, Amy, Morrow, Gary, Reyes, Arthur, Cheu, Melissa, Li, Jessica, Wallin, Jeffrey J., Tsai, Siao, Sun, Laura, Wang, Peiyin, Ellerman, Diego, Spiess, Christoph, Polson, Andy, Stefanich, Eric G., Kamath, Amrita V., Ovacik, Meric A.
Publicado 2022

Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing

por Li, Ji, Stagg, Nicola J., Johnston, Jennifer, Harris, Michael J., Menzies, Sam A., DiCara, Danielle, Clark, Vanessa, Hristopoulos, Maria, Cook, Ryan, Slaga, Dionysos, Nakamura, Rin, McCarty, Luke, Sukumaran, Siddharth, Luis, Elizabeth, Ye, Zhengmao, Wu, Thomas D., Sumiyoshi, Teiko, Danilenko, Dimitry, Lee, Genee Y., Totpal, Klara, Ellerman, Diego, Hötzel, Isidro, James, John R., Junttila, Teemu T.
Publicado 2017

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

por Yang, Yanli, Yeh, Sherry H., Madireddi, Shravan, Matochko, Wadim L., Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F., Leonard, Brandon, Scales, Suzie J., Zhu, Jing W., Christensen, Erin, Hang, Julie Q., Brezski, Randall J., Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M., Lazar, Greg A.
Publicado 2019