Maintenance of Complex Trait Variation: Classic Theory and Modern Data

por Koch, Evan M., Sunyaev, Shamil R.
Publicado 2021

Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)

por Sunyaev, Shamil R., Lugovskoy, Alexey, Simon, Kenneth, Gorelik, Leonid
Publicado 2009

Shared associations identify causal relationships between gene expression and immune cell phenotypes

por Gasperi, Christiane, Chun, Sung, Sunyaev, Shamil R., Cotsapas, Chris
Publicado 2021

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection

por Lenz, Tobias L., Spirin, Victor, Jordan, Daniel M., Sunyaev, Shamil R.
Publicado 2016

StrVCTVRE: A supervised learning method to predict the pathogenicity of human genome structural variants

por Sharo, Andrew G., Hu, Zhiqiang, Sunyaev, Shamil R., Brenner, Steven E.
Publicado 2022

Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck

por Balick, Daniel J., Do, Ron, Cassa, Christopher A., Reich, David, Sunyaev, Shamil R.
Publicado 2015

Replicate sequencing libraries are important for quantification of allelic imbalance

por Mendelevich, Asia, Vinogradova, Svetlana, Gupta, Saumya, Mironov, Andrey A., Sunyaev, Shamil R., Gimelbrant, Alexander A.
Publicado 2021

PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants

por Bodea, Corneliu A., Mitchell, Adele A., Bloemendal, Alex, Day-Williams, Aaron G., Runz, Heiko, Sunyaev, Shamil R.
Publicado 2018

Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy

por Radke, David W., Sul, Jae Hoon, Balick, Daniel J., Akle, Sebastian, Green, Robert C., Sunyaev, Shamil R.
Publicado 2021

A method and server for predicting damaging missense mutations

por Adzhubei, Ivan A., Schmidt, Steffen, Peshkin, Leonid, Ramensky, Vasily E., Gerasimova, Anna, Bork, Peer, Kondrashov, Alexey S., Sunyaev, Shamil R.
Publicado 2010

The missing link between genetic association and regulatory function

por Connally, Noah J, Nazeen, Sumaiya, Lee, Daniel, Shi, Huwenbo, Stamatoyannopoulos, John, Chun, Sung, Cotsapas, Chris, Cassa, Christopher A, Sunyaev, Shamil R
Publicado 2022

Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations

por Seplyarskiy, Vladimir B., Akkuratov, Evgeny E., Akkuratova, Natalia, Andrianova, Maria A., Nikolaev, Sergey I., Bazykin, Georgii A., Adameyko, Igor, Sunyaev, Shamil R.
Publicado 2018

Identification of cancer driver genes based on nucleotide context

por Dietlein, Felix, Weghorn, Donate, Taylor-Weiner, Amaro, Richters, André, Reardon, Brendan, Liu, David, Lander, Eric S., Van Allen, Eliezer M., Sunyaev, Shamil R.
Publicado 2020

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune disease-associated loci in three major immune cell types

por Chun, Sung, Casparino, Alexandra, Patsopoulos, Nikolaos A, Croteau-Chonka, Damien C, Raby, Benjamin A, De Jager, Philip L, Sunyaev, Shamil R, Cotsapas, Chris
Publicado 2017

Cell-of-origin chromatin organization shapes the mutational landscape of cancer

por Polak, Paz, Karlić, Rosa, Koren, Amnon, Thurman, Robert, Sandstrom, Richard, Lawrence, Michael, Reynolds, Alex, Rynes, Eric, Vlahoviček, Kristian, Stamatoyannopoulos, John A., Sunyaev, Shamil R.
Publicado 2015

Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

por Polak, Paz, Lawrence, Michael S., Haugen, Eric, Stoletzki, Nina, Stojanov, Petar, Thurman, Robert E, Garraway, Levi A., Mirkin, Sergei, Getz, Gad, Stamatoyannopoulos, John A., Sunyaev, Shamil R.
Publicado 2013

Genes with monoallelic expression contribute disproportionately to genetic diversity in humans

por Savova, Virginia, Chun, Sung, Sohail, Mashaal, McCole, Ruth B., Witwicki, Robert, Gai, Lisa, Lenz, Tobias L., Wu, C.-ting, Sunyaev, Shamil R., Gimelbrant, Alexander A.
Publicado 2016

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

por Schoech, Armin P., Jordan, Daniel M., Loh, Po-Ru, Gazal, Steven, O’Connor, Luke J., Balick, Daniel J., Palamara, Pier F., Finucane, Hilary K., Sunyaev, Shamil R., Price, Alkes L.
Publicado 2019

Genomic variation landscape of the human gut microbiome

por Schloissnig, Siegfried, Arumugam, Manimozhiyan, Sunagawa, Shinichi, Mitreva, Makedonka, Tap, Julien, Zhu, Ana, Waller, Alison, Mende, Daniel R., Kultima, Jens Roat, Martin, John, Kota, Karthik, Sunyaev, Shamil R., Weinstock, George M., Bork, Peer
Publicado 2012

Estimating the Selective Effects of Heterozygous Protein Truncating Variants from Human Exome Data

por Cassa, Christopher A., Weghorn, Donate, Balick, Daniel J., Jordan, Daniel M., Nusinow, David, Samocha, Kaitlin E., O’Donnell-Luria, Anne, MacArthur, Daniel G., Daly, Mark J., Beier, David R., Sunyaev, Shamil R.
Publicado 2017