Directed Evolution Reveals the Binding Motif Preference of the LC8/DYNLL Hub Protein and Predicts Large Numbers of Novel Binders in the Human Proteome

por Rapali, Péter, Radnai, László, Süveges, Dániel, Harmat, Veronika, Tölgyesi, Ferenc, Wahlgren, Weixiao Y., Katona, Gergely, Nyitray, László, Pál, Gábor
Publicado 2011

Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups

por Gebresilase, Tewodros, Finan, Chris, Suveges, Daniel, Tessema, Tesfaye Sisay, Aseffa, Abraham, Davey, Gail, Hatzikotoulas, Konstantinos, Zeggini, Eleftheria, Newport, Melanie J., Tekola-Ayele, Fasil
Publicado 2021

Population‐wide copy number variation calling using variant call format files from 6,898 individuals

por Png, Grace, Suveges, Daniel, Park, Young‐Chan, Walter, Klaudia, Kundu, Kousik, Ntalla, Ioanna, Tsafantakis, Emmanouil, Karaleftheri, Maria, Dedoussis, George, Zeggini, Eleftheria, Gilly, Arthur
Publicado 2019

A novel variant in GLIS3 is associated with osteoarthritis

por Casalone, Elisabetta, Tachmazidou, Ioanna, Zengini, Eleni, Hatzikotoulas, Konstantinos, Hackinger, Sophie, Suveges, Daniel, Steinberg, Julia, Rayner, Nigel William, Wilkinson, Jeremy Mark, Panoutsopoulou, Kalliope, Zeggini, Eleftheria
Publicado 2018

Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

por Southam, Lorraine, Gilly, Arthur, Süveges, Dániel, Farmaki, Aliki-Eleni, Schwartzentruber, Jeremy, Tachmazidou, Ioanna, Matchan, Angela, Rayner, Nigel W., Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Publicado 2017

Whole-genome sequencing analysis of the cardiometabolic proteome

por Gilly, Arthur, Park, Young-Chan, Png, Grace, Barysenka, Andrei, Fischer, Iris, Bjørnland, Thea, Southam, Lorraine, Suveges, Daniel, Neumeyer, Sonja, Rayner, N. William, Tsafantakis, Emmanouil, Karaleftheri, Maria, Dedoussis, George, Zeggini, Eleftheria
Publicado 2020

Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations

por Kuchenbaecker, Karoline, Gilly, Arthur, Suveges, Daniel, Southam, Lorraine, Giannakopoulou, Olga, Kilian, Britt, Tsafantakis, Emmanouil, Karaleftheri, Maria, Farmaki, Aliki-Eleni, Gurdasani, Deepti, Kundu, Kousik, Sandhu, Manjinder S., Danesh, John, Butterworth, Adam, Barroso, Inês, Dedoussis, George, Zeggini, Eleftheria
Publicado 2022

Network expansion of genetic associations defines a pleiotropy map of human cell biology

por Barrio-Hernandez, Inigo, Schwartzentruber, Jeremy, Shrivastava, Anjali, del-Toro, Noemi, Gonzalez, Asier, Zhang, Qian, Mountjoy, Edward, Suveges, Daniel, Ochoa, David, Ghoussaini, Maya, Bradley, Glyn, Hermjakob, Henning, Orchard, Sandra, Dunham, Ian, Anderson, Carl A., Porras, Pablo, Beltrao, Pedro
Publicado 2023

Very low-depth whole-genome sequencing in complex trait association studies

por Gilly, Arthur, Southam, Lorraine, Suveges, Daniel, Kuchenbaecker, Karoline, Moore, Rachel, Melloni, Giorgio E M, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Ritchie, Graham, Schwartzentruber, Jeremy, Danecek, Petr, Kilian, Britt, Pollard, Martin O, Ge, Xiangyu, Tsafantakis, Emmanouil, Dedoussis, George, Zeggini, Eleftheria
Publicado 2019

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

por Grarup, Niels, Moltke, Ida, Andersen, Mette K., Dalby, Maria, Vitting-Seerup, Kristoffer, Kern, Timo, Mahendran, Yuvaraj, Jørsboe, Emil, Larsen, Christina V. L., Dahl-Petersen, Inger K., Gilly, Arthur, Suveges, Daniel, Dedoussis, George, Zeggini, Eleftheria, Pedersen, Oluf, Andersson, Robin, Bjerregaard, Peter, Jørgensen, Marit E., Albrechtsen, Anders, Hansen, Torben
Publicado 2018

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

por Tachmazidou, Ioanna, Hatzikotoulas, Konstantinos, Southam, Lorraine, Esparza-Gordillo, Jorge, Haberland, Valeriia, Zheng, Jie, Johnson, Toby, Koprulu, Mine, Zengini, Eleni, Steinberg, Julia, Wilkinson, Jeremy M, Bhatnagar, Sahir, Hoffman, Joshua D, Buchan, Natalie, Süveges, Dániel, Yerges-Armstrong, Laura, Smith, George Davey, Gaunt, Tom R, Scott, Robert A, McCarthy, Linda C, Zeggini, Eleftheria
Publicado 2019

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

por Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria
Publicado 2018

Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

por Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria
Publicado 2018

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

por Zengini, Eleni, Hatzikotoulas, Konstantinos, Tachmazidou, Ioanna, Steinberg, Julia, Hartwig, Fernando P., Southam, Lorraine, Hackinger, Sophie, Boer, Cindy G., Styrkarsdottir, Unnur, Gilly, Arthur, Suveges, Daniel, Killian, Britt, Ingvarsson, Thorvaldur, Jonsson, Helgi, Babis, George C., McCaskie, Andrew, Uitterlinden, Andre G., van Meurs, Joyce B. J., Thorsteinsdottir, Unnur, Stefansson, Kari, Smith, George Davey, Wilkinson, Jeremy M., Zeggini, Eleftheria
Publicado 2018

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

por Buniello, Annalisa, MacArthur, Jacqueline A L, Cerezo, Maria, Harris, Laura W, Hayhurst, James, Malangone, Cinzia, McMahon, Aoife, Morales, Joannella, Mountjoy, Edward, Sollis, Elliot, Suveges, Daniel, Vrousgou, Olga, Whetzel, Patricia L, Amode, Ridwan, Guillen, Jose A, Riat, Harpreet S, Trevanion, Stephen J, Hall, Peggy, Junkins, Heather, Flicek, Paul, Burdett, Tony, Hindorff, Lucia A, Cunningham, Fiona, Parkinson, Helen
Publicado 2019

Open Targets Platform: supporting systematic drug–target identification and prioritisation

por Ochoa, David, Hercules, Andrew, Carmona, Miguel, Suveges, Daniel, Gonzalez-Uriarte, Asier, Malangone, Cinzia, Miranda, Alfredo, Fumis, Luca, Carvalho-Silva, Denise, Spitzer, Michaela, Baker, Jarrod, Ferrer, Javier, Raies, Arwa, Razuvayevskaya, Olesya, Faulconbridge, Adam, Petsalaki, Eirini, Mutowo, Prudence, Machlitt-Northen, Sandra, Peat, Gareth, McAuley, Elaine, Ong, Chuang Kee, Mountjoy, Edward, Ghoussaini, Maya, Pierleoni, Andrea, Papa, Eliseo, Pignatelli, Miguel, Koscielny, Gautier, Karim, Mohd, Schwartzentruber, Jeremy, Hulcoop, David G, Dunham, Ian, McDonagh, Ellen M
Publicado 2020

The next-generation Open Targets Platform: reimagined, redesigned, rebuilt

por Ochoa, David, Hercules, Andrew, Carmona, Miguel, Suveges, Daniel, Baker, Jarrod, Malangone, Cinzia, Lopez, Irene, Miranda, Alfredo, Cruz-Castillo, Carlos, Fumis, Luca, Bernal-Llinares, Manuel, Tsukanov, Kirill, Cornu, Helena, Tsirigos, Konstantinos, Razuvayevskaya, Olesya, Buniello, Annalisa, Schwartzentruber, Jeremy, Karim, Mohd, Ariano, Bruno, Martinez Osorio, Ricardo Esteban, Ferrer, Javier, Ge, Xiangyu, Machlitt-Northen, Sandra, Gonzalez-Uriarte, Asier, Saha, Shyamasree, Tirunagari, Santosh, Mehta, Chintan, Roldán-Romero, Juan María, Horswell, Stuart, Young, Sarah, Ghoussaini, Maya, Hulcoop, David G, Dunham, Ian, McDonagh, Ellen M
Publicado 2022

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics

por Ghoussaini, Maya, Mountjoy, Edward, Carmona, Miguel, Peat, Gareth, Schmidt, Ellen M, Hercules, Andrew, Fumis, Luca, Miranda, Alfredo, Carvalho-Silva, Denise, Buniello, Annalisa, Burdett, Tony, Hayhurst, James, Baker, Jarrod, Ferrer, Javier, Gonzalez-Uriarte, Asier, Jupp, Simon, Karim, Mohd Anisul, Koscielny, Gautier, Machlitt-Northen, Sandra, Malangone, Cinzia, Pendlington, Zoe May, Roncaglia, Paola, Suveges, Daniel, Wright, Daniel, Vrousgou, Olga, Papa, Eliseo, Parkinson, Helen, MacArthur, Jacqueline A L, Todd, John A, Barrett, Jeffrey C, Schwartzentruber, Jeremy, Hulcoop, David G, Ochoa, David, McDonagh, Ellen M, Dunham, Ian
Publicado 2020

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

por Tachmazidou, Ioanna, Süveges, Dániel, Min, Josine L., Ritchie, Graham R.S., Steinberg, Julia, Walter, Klaudia, Iotchkova, Valentina, Schwartzentruber, Jeremy, Huang, Jie, Memari, Yasin, McCarthy, Shane, Crawford, Andrew A., Bombieri, Cristina, Cocca, Massimiliano, Farmaki, Aliki-Eleni, Gaunt, Tom R., Jousilahti, Pekka, Kooijman, Marjolein N., Lehne, Benjamin, Malerba, Giovanni, Männistö, Satu, Matchan, Angela, Medina-Gomez, Carolina, Metrustry, Sarah J., Nag, Abhishek, Ntalla, Ioanna, Paternoster, Lavinia, Rayner, Nigel W., Sala, Cinzia, Scott, William R., Shihab, Hashem A., Southam, Lorraine, St Pourcain, Beate, Traglia, Michela, Trajanoska, Katerina, Zaza, Gialuigi, Zhang, Weihua, Artigas, María S., Bansal, Narinder, Benn, Marianne, Chen, Zhongsheng, Danecek, Petr, Lin, Wei-Yu, Locke, Adam, Luan, Jian’an, Manning, Alisa K., Mulas, Antonella, Sidore, Carlo, Tybjaerg-Hansen, Anne, Varbo, Anette, Zoledziewska, Magdalena, Finan, Chris, Hatzikotoulas, Konstantinos, Hendricks, Audrey E., Kemp, John P., Moayyeri, Alireza, Panoutsopoulou, Kalliope, Szpak, Michal, Wilson, Scott G., Boehnke, Michael, Cucca, Francesco, Di Angelantonio, Emanuele, Langenberg, Claudia, Lindgren, Cecilia, McCarthy, Mark I., Morris, Andrew P., Nordestgaard, Børge G., Scott, Robert A., Tobin, Martin D., Wareham, Nicholas J., Burton, Paul, Chambers, John C., Smith, George Davey, Dedoussis, George, Felix, Janine F., Franco, Oscar H., Gambaro, Giovanni, Gasparini, Paolo, Hammond, Christopher J., Hofman, Albert, Jaddoe, Vincent W.V., Kleber, Marcus, Kooner, Jaspal S., Perola, Markus, Relton, Caroline, Ring, Susan M., Rivadeneira, Fernando, Salomaa, Veikko, Spector, Timothy D., Stegle, Oliver, Toniolo, Daniela, Uitterlinden, André G., Barroso, Inês, Greenwood, Celia M.T., Perry, John R.B., Walker, Brian R., Butterworth, Adam S., Xue, Yali, Durbin, Richard, Small, Kerrin S., Soranzo, Nicole, Timpson, Nicholas J., Zeggini, Eleftheria
Publicado 2017