Agile software development one year into the COVID-19 pandemic

por Ågren, Pernilla, Knoph, Eli, Berntsson Svensson, Richard
Publicado 2022

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

por Karlgren, Maria, Ahlin, Gustav, Bergström, Christel A. S., Svensson, Richard, Palm, Johan, Artursson, Per
Publicado 2011

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

por Sunduru, Naresh, Svensson, Mona, Cipriano, Mariateresa, Marwaha, Sania, Andersson, C. David, Svensson, Richard, Fowler, Christopher J., Elofsson, Mikael
Publicado 2017

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

por Rendo, Veronica, Kundu, Snehangshu, Rameika, Natallia, Ljungström, Viktor, Svensson, Richard, Palin, Kimmo, Aaltonen, Lauri, Stoimenov, Ivaylo, Sjöblom, Tobias
Publicado 2020

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase

por Lindgren, Cecilia, Forsgren, Nina, Hoster, Norman, Akfur, Christine, Artursson, Elisabet, Edvinsson, Lotta, Svensson, Richard, Worek, Franz, Ekström, Fredrik, Linusson, Anna
Publicado 2022

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

por Islam, Md. Koushikul, Strand, Mårten, Saleeb, Michael, Svensson, Richard, Baranczewski, Pawel, Artursson, Per, Wadell, Göran, Ahlm, Clas, Elofsson, Mikael, Evander, Magnus
Publicado 2018

Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation

por Kuang, Qie, Purhonen, Pasi, Ålander, Johan, Svensson, Richard, Hoogland, Veronika, Winerdal, Jens, Spahiu, Linda, Ottosson-Wadlund, Astrid, Jegerschöld, Caroline, Morgenstern, Ralf, Hebert, Hans
Publicado 2017

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

por Rendo, Veronica, Stoimenov, Ivaylo, Mateus, André, Sjöberg, Elin, Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Ng, Adrian, OʼBrien, Casey, Giannakis, Marios, Artursson, Per, Nygren, Peter, Cheong, Ian, Sjöblom, Tobias
Publicado 2020

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

por Kulén, Martina, Núñez-Otero, Carlos, Cairns, Andrew G., Silver, Jim, Lindgren, Anders E. G., Wede, Emma, Singh, Pardeep, Vielfort, Katarina, Bahnan, Wael, Good, James A. D., Svensson, Richard, Bergström, Sven, Gylfe, Åsa, Almqvist, Fredrik
Publicado 2019

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

por Over, Björn, McCarren, Patrick, Artursson, Per, Foley, Michael, Giordanetto, Fabrizio, Grönberg, Gunnar, Hilgendorf, Constanze, Lee, Maurice D., Matsson, Pär, Muncipinto, Giovanni, Pellisson, Mélanie, Perry, Matthew W. D., Svensson, Richard, Duvall, Jeremy R., Kihlberg, Jan
Publicado 2014

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

por Al-Amin, Rasel A, Johansson, Lars, Abdurakhmanov, Eldar, Landegren, Nils, Löf, Liza, Arngården, Linda, Blokzijl, Andries, Svensson, Richard, Hammond, Maria, Lönn, Peter, Haybaeck, Johannes, Kamali-Moghaddam, Masood, Jensen, Annika Jenmalm, Danielson, U Helena, Artursson, Per, Lundbäck, Thomas, Landegren, Ulf
Publicado 2022

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

por Ladds, Marcus J. G. W., Pastor-Fernández, Andrés, Popova, Gergana, van Leeuwen, Ingeborg M. M., Eng, Kai Er, Drummond, Catherine J., Johansson, Lars, Svensson, Richard, Westwood, Nicholas J., McCarthy, Anna R., Tholander, Fredrik, Popa, Mihaela, Lane, David P., McCormack, Emmet, McInerney, Gerald M., Bhatia, Ravi, Laín, Sonia
Publicado 2018

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

por Cotman, Andrej Emanuel, Durcik, Martina, Benedetto Tiz, Davide, Fulgheri, Federica, Secci, Daniela, Sterle, Maša, Možina, Štefan, Skok, Žiga, Zidar, Nace, Zega, Anamarija, Ilaš, Janez, Peterlin Mašič, Lucija, Tomašič, Tihomir, Hughes, Diarmaid, Huseby, Douglas L., Cao, Sha, Garoff, Linnéa, Berruga Fernández, Talía, Giachou, Paraskevi, Crone, Lisa, Simoff, Ivailo, Svensson, Richard, Birnir, Bryndis, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., de la Cruz, Mercedes, Glinghammar, Björn, Lenhammar, Lena, Henderson, Sara R., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel
Publicado 2023

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

por Durcik, Martina, Cotman, Andrej Emanuel, Toplak, Žan, Možina, Štefan, Skok, Žiga, Szili, Petra Eva, Czikkely, Márton, Maharramov, Elvin, Vu, Thu Hien, Piras, Maria Vittoria, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Trontelj, Jurij, Pardo, Luis A., Hughes, Diarmaid, Huseby, Douglas, Berruga-Fernández, Tália, Cao, Sha, Simoff, Ivailo, Svensson, Richard, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Glinghammar, Björn, Sjöström, Eva, Bohlin, Martin, Oreskär, Joanna, Alvér, Sofie, Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel, Pal, Csaba, Tomašič, Tihomir, Peterlin Mašič, Lucija
Publicado 2023

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Fernández, Andrés Pastor, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado 2023

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado 2018

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado 2018

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

por Bonagas, Nadilly, Gustafsson, Nina M. S., Henriksson, Martin, Marttila, Petra, Gustafsson, Robert, Wiita, Elisée, Borhade, Sanjay, Green, Alanna C., Vallin, Karl S. A., Sarno, Antonio, Svensson, Richard, Göktürk, Camilla, Pham, Therese, Jemth, Ann-Sofie, Loseva, Olga, Cookson, Victoria, Kiweler, Nicole, Sandberg, Lars, Rasti, Azita, Unterlass, Judith E., Haraldsson, Martin, Andersson, Yasmin, Scaletti, Emma R., Bengtsson, Christoffer, Paulin, Cynthia B. J., Sanjiv, Kumar, Abdurakhmanov, Eldar, Pudelko, Linda, Kunz, Ben, Desroses, Matthieu, Iliev, Petar, Färnegårdh, Katarina, Krämer, Andreas, Garg, Neeraj, Michel, Maurice, Häggblad, Sara, Jarvius, Malin, Kalderén, Christina, Jensen, Amanda Bögedahl, Almlöf, Ingrid, Karsten, Stella, Zhang, Si Min, Häggblad, Maria, Eriksson, Anders, Liu, Jianping, Glinghammar, Björn, Nekhotiaeva, Natalia, Klingegård, Fredrik, Koolmeister, Tobias, Martens, Ulf, Llona-Minguez, Sabin, Moulson, Ruth, Nordström, Helena, Parrow, Vendela, Dahllund, Leif, Sjöberg, Birger, Vargas, Irene L., Vo, Duy Duc, Wannberg, Johan, Knapp, Stefan, Krokan, Hans E., Arvidsson, Per I., Scobie, Martin, Meiser, Johannes, Stenmark, Pål, Berglund, Ulrika Warpman, Homan, Evert J., Helleday, Thomas
Publicado 2022