Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy

por Watt, Andrew T., Swayze, Grant, Swayze, Eric E., Freier, Susan M.
Publicado 2020

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

por Seth, Punit P, Jazayeri, Ali, Yu, Jeff, Allerson, Charles R, Bhat, Balkrishen, Swayze, Eric E
Publicado 2012

S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5′-Vinylphosphonate

por Nikan, Mehran, Li, Wenyu, Kinberger, Garth A., Seth, Punit P., Swayze, Eric E., Prakash, Thazha P.
Publicado 2019

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

por Gaus, Hans J, Gupta, Ruchi, Chappell, Alfred E, Østergaard, Michael E, Swayze, Eric E, Seth, Punit P
Publicado 2019

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

por Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.
Publicado 2017

A modular analysis of microglia gene expression, insights into the aged phenotype

por Cho, Christine E., Damle, Sagar S., Wancewicz, Edward V., Mukhopadhyay, Swagatam, Hart, Christopher E., Mazur, Curt, Swayze, Eric E., Kamme, Fredrik
Publicado 2019

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

por Swayze, Eric E., Siwkowski, Andrew M., Wancewicz, Edward V., Migawa, Michael T., Wyrzykiewicz, Tadeusz K., Hung, Gene, Monia, Brett P., Bennett, and C. Frank
Publicado 2007

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy

por Liu, Jing, Yu, Dongbo, Aiba, Yuichiro, Pendergraff, Hannah, Swayze, Eric E., Lima, Walt F., Hu, Jiaxin, Prakash, Thazha P., Corey, David R.
Publicado 2013

Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice

por Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P
Publicado 2020

TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and...

por Murray, Sue, Ittig, Damian, Koller, Erich, Berdeja, Andres, Chappell, Alfred, Prakash, Thazha P., Norrbom, Michaela, Swayze, Eric E., Leumann, Christian J., Seth, Punit P.
Publicado 2012

Competition for RISC binding predicts in vitro potency of siRNA

por Koller, Erich, Propp, Stephanie, Murray, Heather, Lima, Walter, Bhat, Balkrishen, Prakash, Thaza P., Allerson, Charles R., Swayze, Eric E., Marcusson, Eric G., Dean, Nicholas M.
Publicado 2006

Potent inhibition of microRNA in vivo without degradation

por Davis, Scott, Propp, Stephanie, Freier, Susan M., Jones, Laura E., Serra, Martin J., Kinberger, Garth, Bhat, Balkrishen, Swayze, Eric E., Bennett, C. Frank, Esau, Christine
Publicado 2009

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

por Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.
Publicado 2017

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

por Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.
Publicado 2017

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

por Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.
Publicado 2021

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

por Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.
Publicado 2021

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado 2015

Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity

por Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Publicado 2017

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

por Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Murray, Heather M., Nichols, Josh G., Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Publicado 2014

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

por Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Publicado 2019