Quantum-based modeling implies that bidentate Arg(89)-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation

por Salter, E. Alan, Wierzbicki, Andrzej, Honkanen, Richard E., Swingle, Mark R.
Publicado 2023

Development of a Synthetic 3-ketosteroid Δ(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells

por D’Arcy, Brandon M., Swingle, Mark R., Schambeau, Lindsay, Pannell, Lewis, Prakash, Aishwarya, Honkanen, Richard E.
Publicado 2019

Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades

por Smolen, Kali A., Papke, Cinta M., Swingle, Mark R., Musiyenko, Alla, Li, Chenchen, Salter, E. Alan, Camp, Ashley D., Honkanen, Richard E., Kettenbach, Arminja N.
Publicado 2023

A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth

por Papke, Cinta M., Smolen, Kali A., Swingle, Mark R., Cressey, Lauren, Heng, Richard A., Toporsian, Mourad, Deng, Liyong, Hagen, Jacob, Shen, Yufeng, Chung, Wendy K., Kettenbach, Arminja N., Honkanen, Richard E.
Publicado 2021

Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth

por Shuhaibar, Leia C., Kaci, Nabil, Egbert, Jeremy R., Horville, Thibault, Loisay, Léa, Vigone, Giulia, Uliasz, Tracy F., Dambroise, Emilie, Swingle, Mark R., Honkanen, Richard E., Duplan, Martin Biosse, Jaffe, Laurinda A., Legeai-Mallet, Laurence
Publicado 2021

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

por Wu, Cheng-Guo, Balakrishnan, Vijaya K., Parihar, Pankaj S., Konovolov, Kirill, Chen, Yu-Chia, Merrill, Ronald A, Wei, Hui, Carragher, Bridget, Sundaresan, Ramya, Cui, Qiang, Wadzinski, Brian E., Swingle, Mark R., Musiyenko, Alla, Honkanen, Richard, Chung, Wendy K., Suzuki, Aussie, Strack, Stefan, Huang, Xuhui, Xing, Yongna
Publicado 2023