Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus

por Deval, Jerome, Symons, Julian A, Beigelman, Leo
Publicado 2014

Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

por Chaudhuri, Shuvam, Symons, Julian A., Deval, Jerome
Publicado 2018

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

por Jordan, Paul C., Liu, Cheng, Raynaud, Pauline, Lo, Michael K., Spiropoulou, Christina F., Symons, Julian A., Beigelman, Leo, Deval, Jerome
Publicado 2018

Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules

por Kao, C. Cheng, Nie, Yuchun, Ren, Suping, De Costa, N. Tilani T.S., Pandey, Rajendra K., Hong, Jin, Smith, David B., Symons, Julian A., Beigelman, Leonid, Blatt, Lawrence M.
Publicado 2021

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

por Deval, Jerome, Fung, Amy, Stevens, Sarah K., Jordan, Paul C., Gromova, Tatiana, Taylor, Joshua S., Hong, Jin, Meng, Jia, Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Symons, Julian A., Beigelman, Leo
Publicado 2016

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development

por Liu, Cheng, Boland, Sandro, Scholle, Michael D., Bardiot, Dorothee, Marchand, Arnaud, Chaltin, Patrick, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Gurard-Levin, Zachary A., Vandyck, Koen, Deval, Jerome
Publicado 2021

Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results

por Oey, Abbie, McClure, Matthew, Symons, Julian A., Chanda, Sushmita, Fry, John, Smith, Patrick F., Luciani, Kathia, Fayon, Michael, Chokephaibulkit, Kulkanya, Uppala, Rattapon, Bernatoniene, Jolanta, Furuno, Kenji, Stanley, Thorsten, Huntjens, Dymphy, Witek, James
Publicado 2023

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

por Gurard-Levin, Zachary A., Liu, Cheng, Jekle, Andreas, Jaisinghani, Ruchika, Ren, Suping, Vandyck, Koen, Jochmans, Dirk, Leyssen, Pieter, Neyts, Johan, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Scholle, Michael D., Deval, Jerome
Publicado 2020

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

por Luong, Xuan G., Stevens, Sarah K., Jekle, Andreas, Lin, Tse-I, Gupta, Kusum, Misner, Dinah, Chanda, Sushmita, Mukherjee, Sucheta, Williams, Caroline, Stoycheva, Antitsa, Blatt, Lawrence M., Beigelman, Leonid N., Symons, Julian A., Raboisson, Pierre, McGowan, David, Vandyck, Koen, Deval, Jerome
Publicado 2020

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

por Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K., Stoycheva, Antitsa, Rajwanshi, Vivek K., Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B., Blatt, Lawrence M., Symons, Julian A., Gonzalvez, Francois, Beigelman, Leonid
Publicado 2023

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

por Vandyck, Koen, Abdelnabi, Rana, Gupta, Kusum, Jochmans, Dirk, Jekle, Andreas, Deval, Jerome, Misner, Dinah, Bardiot, Dorothée, Foo, Caroline S., Liu, Cheng, Ren, Suping, Beigelman, Leonid, Blatt, Lawrence M., Boland, Sandro, Vangeel, Laura, Dejonghe, Steven, Chaltin, Patrick, Marchand, Arnaud, Serebryany, Vladimir, Stoycheva, Antitsa, Chanda, Sushmita, Symons, Julian A., Raboisson, Pierre, Neyts, Johan
Publicado 2021

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

por Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K., Fung, Amy, Stevens, Sarah K., Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D., Serebryany, Vladimir, Liu, Jyanwei, Smith, David B., Tam, Yuen, Zhang, Qingling, Moore, Martin L., Fearns, Rachel, Chanda, Sushmita M., Blatt, Lawrence M., Symons, Julian A., Beigelman, Leo
Publicado 2015

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

por Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K., De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen
Publicado 2023