Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

por Serneels, Lutgarde, T’Syen, Dries, Perez-Benito, Laura, Theys, Tom, Holt, Matthew G., De Strooper, Bart
Publicado 2020

Selective inhibitors of the PSEN1–gamma-secretase complex

por Serneels, Lutgarde, Narlawar, Rajeshwar, Perez-Benito, Laura, Municoy, Marti, Guallar, Victor, T’Syen, Dries, Dewilde, Maarten, Bischoff, François, Fraiponts, Erwin, Tresadern, Gary, Roevens, Peter W.M., Gijsen, Harrie J.M., De Strooper, Bart
Publicado 2023

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

por Balusu, Sriram, Horré, Katrien, Thrupp, Nicola, Craessaerts, Katleen, Snellinx, An, Serneels, Lutgarde, T’Syen, Dries, Chrysidou, Iordana, Arranz, Amaia M., Sierksma, Annerieke, Simrén, Joel, Karikari, Thomas K., Zetterberg, Henrik, Chen, Wei-Ting, Thal, Dietmar Rudolf, Salta, Evgenia, Fiers, Mark, De Strooper, Bart
Publicado 2023