Structure-based development of new cyclic compounds targeting PSD-95 PDZ3 domain

por Naik, Mandar T., Naik, Nandita, Hu, Tony, Wang, Szu-Huan, Marshall, John
Publicado 2023

A squalene synthase-like enzyme initiates production of tetraterpenoid hydrocarbons in Botryococcus braunii Race L

por Thapa, Hem R., Naik, Mandar T., Okada, Shigeru, Takada, Kentaro, Molnár, István, Xu, Yuquan, Devarenne, Timothy P.
Publicado 2016

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.

por Perdikari, Theodora Myrto, Murthy, Anastasia C., Ryan, Veronica H., Watters, Scott, Naik, Mandar T., Fawzi, Nicolas L.
Publicado 2020

Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid–liquid phase separation and aggregation

por Ryan, Veronica H, Watters, Scott, Amaya, Joshua, Khatiwada, Balabhadra, Venditti, Vincenzo, Naik, Mandar T, Fawzi, Nicolas L
Publicado 2020

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

por Perdikari, Theodora Myrto, Murthy, Anastasia C, Ryan, Veronica H, Watters, Scott, Naik, Mandar T, Fawzi, Nicolas L
Publicado 2020

Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary

por Clark, Haley, Knapik, Laura O., Zhang, Zijing, Wu, Xiaotian, Naik, Mandar T., Oulhen, Nathalie, Wessel, Gary M., Brayboy, Lynae M.
Publicado 2019

Discovering Biomass Structural Determinants Defining the Properties of Plant-Derived Renewable Carbon Fiber

por Li, Qiang, Hu, Cheng, Li, Mengjie, Truong, Phuc, Naik, Mandar T., Prabhu, Dwarkanath, Hoffmann, Leo, Rooney, William L., Yuan, Joshua S.
Publicado 2020

Predicting the viability of beta-lactamase: How folding and binding free energies correlate with beta-lactamase fitness

por Yang, Jordan, Naik, Nandita, Patel, Jagdish Suresh, Wylie, Christopher S., Gu, Wenze, Huang, Jessie, Ytreberg, F. Marty, Naik, Mandar T., Weinreich, Daniel M., Rubenstein, Brenda M.
Publicado 2020

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration

por Ryan, Veronica H, Perdikari, Theodora M, Naik, Mandar T, Saueressig, Camillo F, Lins, Jeremy, Dignon, Gregory L, Mittal, Jeetain, Hart, Anne C, Fawzi, Nicolas L
Publicado 2020

Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

por Naik, Mandar T., Kang, Mooseok, Ho, Chun-Chen, Liao, Pei-Hsin, Hsieh, Yung-Lin, Naik, Nandita M., Wang, Szu-Huan, Chang, Iksoo, Shih, Hsiu-Ming, Huang, Tai-Huang
Publicado 2017

Author Correction: Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

por Naik, Mandar T., Kang, Mooseok, Ho, Chun-Chen, Liao, Pei-Hsin, Hsieh, Yung-Lin, Naik, Nandita M., Wang, Szu-Huan, Chang, Iksoo, Shih, Hsiu-Ming, Huang, Tai-Huang
Publicado 2018

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase

por Soma, Shivatheja, Morgada, Marcos N., Naik, Mandar T., Boulet, Aren, Roesler, Anna A., Dziuba, Nathaniel, Ghosh, Alok, Yu, Qinhong, Lindahl, Paul A., Ames, James B., Leary, Scot C., Vila, Alejandro J., Gohil, Vishal M.
Publicado 2019

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

por Wang, Ailin, Conicella, Alexander E, Schmidt, Hermann Broder, Martin, Erik W, Rhoads, Shannon N, Reeb, Ashley N, Nourse, Amanda, Ramirez Montero, Daniel, Ryan, Veronica H, Rohatgi, Rajat, Shewmaker, Frank, Naik, Mandar T, Mittag, Tanja, Ayala, Yuna M, Fawzi, Nicolas L
Publicado 2018

Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain

por Clark, Nathaniel E., Katolik, Adam, Gallant, Pascal, Welch, Anastasia, Murphy, Eileen, Buerer, Luke, Schorl, Christoph, Naik, Nandita, Naik, Mandar T., Holloway, Stephen P., Cano, Kristin, Weintraub, Susan T., Howard, Katherine M., Hart, P. John, Jogl, Gerwald, Damha, Masad J., Fairbrother, William G.
Publicado 2023

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

por Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Lee, Chun Geun, Elias, Jack A., Campbell, Kerry S., Naik, Mandar T., Atwood, Walter J., Youssef, Emile, Pachter, Jonathan A., Navaraj, Arunasalam, Seyhan, Attila A., Liang, Olin, El-Deiry, Wafik S.
Publicado 2020

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection

por Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Geun Lee, Chun, A. Elias, Jack, S. Campbell, Kerry, T. Naik, Mandar, J. Atwood, Walter, Youssef, Emile, A. Pachter, Jonathan, Navaraj, Arunasalam, A. Seyhan, Attila, Liang, Olin, El-Deiry, Wafik S.
Publicado 2020

Reciprocal inhibition of PIN1 and APC/C(CDH1) controls timely G1/S transition and creates therapeutic vulnerability

por Ke, Shizhong, Dang, Fabin, Wang, Lin, Chen, Jia-Yun, Naik, Mandar T., Thavamani, Abhishek, Liu, Yansheng, Li, Wenxue, Kim, Nami, Naik, Nandita M., Sui, Huaxiu, Tang, Wei, Qiu, Chenxi, Koikawa, Kazuhiro, Batalini, Felipe, Wang, Xiaodong, Clohessy, John G., Heng, Yujing Jan, Lahav, Galit, Gray, Nathanael S., Zho, Xiao Zhen, Wei, Wenyi, Wulf, Gerburg M., Lu, Kun Ping
Publicado 2023