Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery

por Qian, Lu, TCW, Julia
Publicado 2021

hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics

por TCW, Julia, Arranz, Amaia M.
Publicado 2023

Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

por Saroja, Sivaprakasam R., Gorbachev, Kirill, TCW, Julia, Goate, Alison M., Pereira, Ana C.
Publicado 2022

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

por Preman, Pranav, TCW, Julia, Calafate, Sara, Snellinx, An, Alfonso-Triguero, Maria, Corthout, Nikky, Munck, Sebastian, Thal, Dietmar Rudolf, Goate, Alison M, De Strooper, Bart, Arranz, Amaia M
Publicado 2021

MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis

por Cao, Jiqing, Huang, Min, Guo, Lei, Zhu, Li, Hou, Jianwei, Zhang, Larry, Pero, Adriana, Ng, Sabrina, El Gaamouch, Farida, Elder, Gregory, Sano, Mary, Goate, Alison, TCW, Julia, Haroutunian, Vahram, Zhang, Bin, Cai, Dongming
Publicado 2020

Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis

por TCW, Julia, Carvalho, Claudia M.B., Yuan, Bo, Gu, Shen, Altheimer, Alyssa N., McCarthy, Shane, Malhotra, Dheeraj, Sebat, Jonathan, Siegel, Arthur J., Rudolph, Uwe, Lupski, James R., Levy, Deborah L., Brennand, Kristen J.
Publicado 2017

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

por TCW, Julia, Wang, Minghui, Pimenova, Anna A., Bowles, Kathryn R., Hartley, Brigham J., Lacin, Emre, Machlovi, Saima I., Abdelaal, Rawan, Karch, Celeste M., Phatnani, Hemali, Slesinger, Paul A., Zhang, Bin, Goate, Alison M., Brennand, Kristen J.
Publicado 2017

Notch inhibition allows oncogene independent generation of iPS cells

por Ichida, Justin K., TCW, Julia, Williams, Luis A., Carter, Ava C., Shi, Yingxiao, Moura, Marcelo T., Ziller, Michael, Singh, Sean, Amabile, Giovanni, Bock, Christoph, Umezawa, Akihiro, Rubin, Lee L., Bradner, James E., Akutsu, Hidenori, Meissner, Alexander, Eggan, Kevin
Publicado 2014

Integration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

por Novikova, Gloriia, Kapoor, Manav, TCW, Julia, Abud, Edsel M., Efthymiou, Anastasia G., Chen, Steven X., Cheng, Haoxiang, Fullard, John F., Bendl, Jaroslav, Liu, Yiyuan, Roussos, Panos, Björkegren, Johan LM, Liu, Yunlong, Poon, Wayne W., Hao, Ke, Marcora, Edoardo, Goate, Alison M.
Publicado 2021

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

por Neff, Ryan A., Wang, Minghui, Vatansever, Sezen, Guo, Lei, Ming, Chen, Wang, Qian, Wang, Erming, Horgusluoglu-Moloch, Emrin, Song, Won-min, Li, Aiqun, Castranio, Emilie L., TCW, Julia, Ho, Lap, Goate, Alison, Fossati, Valentina, Noggle, Scott, Gandy, Sam, Ehrlich, Michelle E., Katsel, Pavel, Schadt, Eric, Cai, Dongming, Brennand, Kristen J., Haroutunian, Vahram, Zhang, Bin
Publicado 2021

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

por Montagne, Axel, Nation, Daniel A., Sagare, Abhay P., Barisano, Giuseppe, Sweeney, Melanie D., Chakhoyan, Ararat, Pachicano, Maricarmen, Joe, Elizabeth, Nelson, Amy R., D’Orazio, Lina M., Buennagel, David P., Harrington, Michael G., Benzinger, Tammie L. S., Fagan, Anne M., Ringman, John M., Schneider, Lon S., Morris, John C., Reiman, Eric M., Caselli, Richard J., Chui, Helena C., TCW, Julia, Chen, Yining, Pa, Judy, Conti, Peter S., Law, Meng, Toga, Arthur W., Zlokovic, Berislav V.
Publicado 2020

Innate immunity protein IFITM3 modulates γ-secretase in Alzheimer disease

por Hur, Ji-Yeun, Frost, Georgia R., Wu, Xianzhong, Crump, Christina, Pan, Si Jia, Wong, Eitan, Barros, Marilia, Li, Thomas, Nie, Pengju, Zhai, Yujia, Wang, Jen Chyong, TCW, Julia, Guo, Lei, McKenzie, Andrew, Ming, Chen, Zhou, Xianxiao, Wang, Minghui, Sagi, Yotam, Renton, Alan E., Esposito, Bianca T., Kim, Yong, Sadleir, Katherine R., Trinh, Ivy, Rissman, Robert A., Vassar, Robert, Zhang, Bin, Johnson, Douglas S., Masliah, Eliezer, Greengard, Paul, Goate, Alison, Li, Yue-Ming
Publicado 2020