Rare Variant Association Testing for Next-Generation Sequencing Data via Hierarchical Clustering

por Tachmazidou, Ioanna, Morris, Andrew, Zeggini, Eleftheria
Publicado 2013

In search of low-frequency and rare variants affecting complex traits

por Panoutsopoulou, Kalliope, Tachmazidou, Ioanna, Zeggini, Eleftheria
Publicado 2013

Genetic Association Mapping via Evolution-Based Clustering of Haplotypes

por Tachmazidou, Ioanna, Verzilli, Claudio J, Iorio, Maria De
Publicado 2007

Bayesian survival analysis in genetic association studies

por Tachmazidou, Ioanna, Andrew, Toby, Verzilli, Claudio J., Johnson, Michael R., De Iorio, Maria
Publicado 2008

Estimating Genome-Wide Significance for Whole-Genome Sequencing Studies

por Xu, ChangJiang, Tachmazidou, Ioanna, Walter, Klaudia, Ciampi, Antonio, Zeggini, Eleftheria, Greenwood, Celia M T
Publicado 2014

A novel variant in GLIS3 is associated with osteoarthritis

por Casalone, Elisabetta, Tachmazidou, Ioanna, Zengini, Eleni, Hatzikotoulas, Konstantinos, Hackinger, Sophie, Suveges, Daniel, Steinberg, Julia, Rayner, Nigel William, Wilkinson, Jeremy Mark, Panoutsopoulou, Kalliope, Zeggini, Eleftheria
Publicado 2018

Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

por Southam, Lorraine, Gilly, Arthur, Süveges, Dániel, Farmaki, Aliki-Eleni, Schwartzentruber, Jeremy, Tachmazidou, Ioanna, Matchan, Angela, Rayner, Nigel W., Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Publicado 2017

Using ancestry-informative markers to identify fine structure across 15 populations of European origin

por Huckins, Laura M, Boraska, Vesna, Franklin, Christopher S, Floyd, James A B, Southam, Lorraine, Sullivan, Patrick F, Bulik, Cynthia M, Collier, David A, Tyler-Smith, Chris, Zeggini, Eleftheria, Tachmazidou, Ioanna
Publicado 2014

Rare variant contribution to human disease in 281,104 UK Biobank exomes

por Wang, Quanli, Dhindsa, Ryan S., Carss, Keren, Harper, Andrew R., Nag, Abhishek, Tachmazidou, Ioanna, Vitsios, Dimitrios, Deevi, Sri V. V., Mackay, Alex, Muthas, Daniel, Hühn, Michael, Monkley, Susan, Olsson, Henric, Wasilewski, Sebastian, Smith, Katherine R., March, Ruth, Platt, Adam, Haefliger, Carolina, Petrovski, Slavé
Publicado 2021

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

por Tachmazidou, Ioanna, Hatzikotoulas, Konstantinos, Southam, Lorraine, Esparza-Gordillo, Jorge, Haberland, Valeriia, Zheng, Jie, Johnson, Toby, Koprulu, Mine, Zengini, Eleni, Steinberg, Julia, Wilkinson, Jeremy M, Bhatnagar, Sahir, Hoffman, Joshua D, Buchan, Natalie, Süveges, Dániel, Yerges-Armstrong, Laura, Smith, George Davey, Gaunt, Tom R, Scott, Robert A, McCarthy, Linda C, Zeggini, Eleftheria
Publicado 2019

A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates

por Tachmazidou, Ioanna, Dedoussis, George, Southam, Lorraine, Farmaki, Aliki-Eleni, Ritchie, Graham R. S., Xifara, Dionysia K., Matchan, Angela, Hatzikotoulas, Konstantinos, Rayner, Nigel W., Chen, Yuan, Pollin, Toni I., O’Connell, Jeffrey R., Yerges-Armstrong, Laura M., Kiagiadaki, Chrysoula, Panoutsopoulou, Kalliope, Schwartzentruber, Jeremy, Moutsianas, Loukas, Tsafantakis, Emmanouil, Tyler-Smith, Chris, McVean, Gil, Xue, Yali, Zeggini, Eleftheria
Publicado 2013

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

por Zengini, Eleni, Hatzikotoulas, Konstantinos, Tachmazidou, Ioanna, Steinberg, Julia, Hartwig, Fernando P., Southam, Lorraine, Hackinger, Sophie, Boer, Cindy G., Styrkarsdottir, Unnur, Gilly, Arthur, Suveges, Daniel, Killian, Britt, Ingvarsson, Thorvaldur, Jonsson, Helgi, Babis, George C., McCaskie, Andrew, Uitterlinden, Andre G., van Meurs, Joyce B. J., Thorsteinsdottir, Unnur, Stefansson, Kari, Smith, George Davey, Wilkinson, Jeremy M., Zeggini, Eleftheria
Publicado 2018

Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants

por Panoutsopoulou, Kalliope, Hatzikotoulas, Konstantinos, Xifara, Dionysia Kiara, Colonna, Vincenza, Farmaki, Aliki-Eleni, Ritchie, Graham R. S., Southam, Lorraine, Gilly, Arthur, Tachmazidou, Ioanna, Fatumo, Segun, Matchan, Angela, Rayner, Nigel W., Ntalla, Ioanna, Mezzavilla, Massimo, Chen, Yuan, Kiagiadaki, Chrysoula, Zengini, Eleni, Mamakou, Vasiliki, Athanasiadis, Antonis, Giannakopoulou, Margarita, Kariakli, Vassiliki-Eirini, Nsubuga, Rebecca N., Karabarinde, Alex, Sandhu, Manjinder, McVean, Gil, Tyler-Smith, Chris, Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Publicado 2014

Height-reducing variants and selection for short stature in Sardinia

por Zoledziewska, Magdalena, Sidore, Carlo, Chiang, Charleston W. K., Sanna, Serena, Mulas, Antonella, Steri, Maristella, Busonero, Fabio, Marcus, Joseph H., Marongiu, Michele, Maschio, Andrea, Ortega Del Vecchyo, Diego, Floris, Matteo, Meloni, Antonella, Delitala, Alessandro, Concas, Maria Pina, Murgia, Federico, Biino, Ginevra, Vaccargiu, Simona, Nagaraja, Ramaiah, Lohmueller, Kirk E., Timpson, Nicholas J., Soranzo, Nicole, Tachmazidou, Ioanna, Dedoussis, George, Zeggini, Eleftheria, Uzzau, Sergio, Jones, Chris, Lyons, Robert, Angius, Andrea, Abecasis, Gonçalo R., Novembre, John, Schlessinger, David, Cucca, Francesco
Publicado 2015

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

por Timpson, Nicholas J., Walter, Klaudia, Min, Josine L., Tachmazidou, Ioanna, Malerba, Giovanni, Shin, So-Youn, Chen, Lu, Futema, Marta, Southam, Lorraine, Iotchkova, Valentina, Cocca, Massimiliano, Huang, Jie, Memari, Yasin, McCarthy, Shane, Danecek, Petr, Muddyman, Dawn, Mangino, Massimo, Menni, Cristina, Perry, John R. B., Ring, Susan M., Gaye, Amadou, Dedoussis, George, Farmaki, Aliki-Eleni, Burton, Paul, Talmud, Philippa J., Gambaro, Giovanni, Spector, Tim D., Smith, George Davey, Durbin, Richard, Richards, J Brent, Humphries, Steve E., Zeggini, Eleftheria, Soranzo, Nicole
Publicado 2014

Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

por Timpson, Nicholas J., Walter, Klaudia, Min, Josine L., Tachmazidou, Ioanna, Malerba, Giovanni, Shin, So-Youn, Chen, Lu, Futema, Marta, Southam, Lorraine, Iotchkova, Valentina, Cocca, Massimiliano, Huang, Jie, Memari, Yasin, McCarthy, Shane, Danecek, Petr, Muddyman, Dawn, Mangino, Massimo, Menni, Cristina, Perry, John R. B., Ring, Susan M., Gaye, Amadou, Dedoussis, George, Farmaki, Aliki-Eleni, Burton, Paul, Talmud, Philippa J., Gambaro, Giovanni, Spector, Tim D., Smith, George Davey, Durbin, Richard, Richards, J. Brent, Humphries, Steve E., Zeggini, Eleftheria, Soranzo, Nicole
Publicado 2015

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

por Hendricks, Audrey E., Bochukova, Elena G., Marenne, Gaëlle, Keogh, Julia M., Atanassova, Neli, Bounds, Rebecca, Wheeler, Eleanor, Mistry, Vanisha, Henning, Elana, Körner, Antje, Muddyman, Dawn, McCarthy, Shane, Hinney, Anke, Hebebrand, Johannes, Scott, Robert A., Langenberg, Claudia, Wareham, Nick J., Surendran, Praveen, Howson, Joanna M., Butterworth, Adam S., Danesh, John, Nordestgaard, Børge G, Nielsen, Sune F, Afzal, Shoaib, Papadia, Sofia, Ashford, Sofie, Garg, Sumedha, Millhauser, Glenn L., Palomino, Rafael I., Kwasniewska, Alexandra, Tachmazidou, Ioanna, O’Rahilly, Stephen, Zeggini, Eleftheria, Barroso, Inês, Farooqi, I. Sadaf
Publicado 2017

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

por Haworth, Simon, Shapland, Chin Yang, Hayward, Caroline, Prins, Bram P., Felix, Janine F., Medina-Gomez, Carolina, Rivadeneira, Fernando, Wang, Carol, Ahluwalia, Tarunveer S., Vrijheid, Martine, Guxens, Mònica, Sunyer, Jordi, Tachmazidou, Ioanna, Walter, Klaudia, Iotchkova, Valentina, Jackson, Andrew, Cleal, Louise, Huffmann, Jennifer, Min, Josine L., Sass, Lærke, Timmers, Paul R. H. J., Davey Smith, George, Fisher, Simon E., Wilson, James F., Cole, Tim J., Fernandez-Orth, Dietmar, Bønnelykke, Klaus, Bisgaard, Hans, Pennell, Craig E., Jaddoe, Vincent W. V., Dedoussis, George, Timpson, Nicholas, Zeggini, Eleftheria, Vitart, Veronique, St Pourcain, Beate
Publicado 2019

The African Genome Variation Project shapes medical genetics in Africa

por Gurdasani, Deepti, Carstensen, Tommy, Tekola-Ayele, Fasil, Pagani, Luca, Tachmazidou, Ioanna, Hatzikotoulas, Konstantinos, Karthikeyan, Savita, Iles, Louise, Pollard, Martin O., Choudhury, Ananyo, Ritchie, Graham R. S., Xue, Yali, Asimit, Jennifer, Nsubuga, Rebecca N., Young, Elizabeth H., Pomilla, Cristina, Kivinen, Katja, Rockett, Kirk, Kamali, Anatoli, Doumatey, Ayo P., Asiki, Gershim, Seeley, Janet, Sisay-Joof, Fatoumatta, Jallow, Muminatou, Tollman, Stephen, Mekonnen, Ephrem, Ekong, Rosemary, Oljira, Tamiru, Bradman, Neil, Bojang, Kalifa, Ramsay, Michele, Adeyemo, Adebowale, Bekele, Endashaw, Motala, Ayesha, Norris, Shane A., Pirie, Fraser, Kaleebu, Pontiano, Kwiatkowski, Dominic, Tyler-Smith, Chris, Rotimi, Charles, Zeggini, Eleftheria, Sandhu, Manjinder S.
Publicado 2014

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

por Ombrello, Michael J, Arthur, Victoria L, Remmers, Elaine F, Hinks, Anne, Tachmazidou, Ioanna, Grom, Alexei A, Foell, Dirk, Martini, Alberto, Gattorno, Marco, Özen, Seza, Prahalad, Sampath, Zeft, Andrew S, Bohnsack, John F, Ilowite, Norman T, Mellins, Elizabeth D, Russo, Ricardo, Len, Claudio, Hilario, Maria Odete E, Oliveira, Sheila, Yeung, Rae S M, Rosenberg, Alan M, Wedderburn, Lucy R, Anton, Jordi, Haas, Johannes-Peter, Rosen-Wolff, Angela, Minden, Kirsten, Tenbrock, Klaus, Demirkaya, Erkan, Cobb, Joanna, Baskin, Elizabeth, Signa, Sara, Shuldiner, Emily, Duerr, Richard H, Achkar, Jean-Paul, Kamboh, M Ilyas, Kaufman, Kenneth M, Kottyan, Leah C, Pinto, Dalila, Scherer, Stephen W, Alarcón-Riquelme, Marta E, Docampo, Elisa, Estivill, Xavier, Gül, Ahmet, Langefeld, Carl D, Thompson, Susan, Zeggini, Eleftheria, Kastner, Daniel L, Woo, Patricia, Thomson, Wendy
Publicado 2017