Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

por Ziff, Oliver J., Clarke, Benjamin E., Taha, Doaa M., Crerar, Hamish, Luscombe, Nicholas M., Patani, Rickie
Publicado 2022

Automated and unbiased discrimination of ALS from control tissue at single cell resolution

por Hagemann, Cathleen, Tyzack, Giulia E., Taha, Doaa M., Devine, Helen, Greensmith, Linda, Newcombe, Jia, Patani, Rickie, Serio, Andrea, Luisier, Raphaëlle
Publicado 2021

Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles

por Clarke, Benjamin E, Taha, Doaa M, Ziff, Oliver J, Alam, Aftab, Thelin, Eric P, García, Núria Marcó, Helmy, Adel, Patani, Rickie
Publicado 2020

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

por Tyzack, Giulia E, Neeves, Jacob, Crerar, Hamish, Klein, Pierre, Ziff, Oliver, Taha, Doaa M, Luisier, Raphaëlle, Luscombe, Nicholas M, Patani, Rickie
Publicado 2021

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis

por Smethurst, Phillip, Risse, Emmanuel, Tyzack, Giulia E, Mitchell, Jamie S, Taha, Doaa M, Chen, Yun-Ru, Newcombe, Jia, Collinge, John, Sidle, Katie, Patani, Rickie
Publicado 2020

Reactive astrocytes in ALS display diminished intron retention

por Ziff, Oliver J, Taha, Doaa M, Crerar, Hamish, Clarke, Benjamin E, Chakrabarti, Anob M, Kelly, Gavin, Neeves, Jacob, Tyzack, Giulia E, Luscombe, Nicholas M, Patani, Rickie
Publicado 2021

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

por Tyzack, Giulia E, Luisier, Raphaelle, Taha, Doaa M, Neeves, Jacob, Modic, Miha, Mitchell, Jamie S, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M, Patani, Rickie
Publicado 2019

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

por Luisier, Raphaelle, Tyzack, Giulia E., Hall, Claire E., Mitchell, Jamie S., Devine, Helen, Taha, Doaa M., Malik, Bilal, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M., Patani, Rickie
Publicado 2018

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

por Taha, Doaa M, Clarke, Benjamin E, Hall, Claire E, Tyzack, Giulia E, Ziff, Oliver J, Greensmith, Linda, Kalmar, Bernadett, Ahmed, Mhoriam, Alam, Aftab, Thelin, Eric P, Garcia, Nuria Marco, Helmy, Adel, Sibley, Christopher R, Patani, Rickie
Publicado 2022