Epidermal growth factor prevents APOE4-induced cognitive and cerebrovascular deficits in female mice

por Thomas, Riya, Morris, Alan W.J., Tai, Leon M.
Publicado 2017

Higher Neuronal Facilitation and Potentiation with APOE4 Suppressed by Angiotensin II

por Scheinman, Sarah B., Tseng, Kuei Y., Alford, Simon, Tai, Leon M
Publicado 2023

APOE4 Promotes Tonic-Clonic Seizures, an Effect Modified by Familial Alzheimer’s Disease Mutations

por Lamoureux, Lorissa, Marottoli, Felecia M., Tseng, Kuei Y., Tai, Leon M.
Publicado 2021

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

por Rodriguez, Gustavo A, Tai, Leon M, LaDu, Mary Jo, Rebeck, G William
Publicado 2014

Introducing Human APOE into Aβ Transgenic Mouse Models

por Tai, Leon M., Youmans, Katherine L., Jungbauer, Lisa, Yu, Chunjiang, LaDu, Mary Jo
Publicado 2011

Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice

por Sugasini, Dhavamani, Thomas, Riya, Yalagala, Poorna C. R., Tai, Leon M., Subbaiah, Papasani V.
Publicado 2017

Peripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction

por Marottoli, Felecia M., Katsumata, Yuriko, Koster, Kevin P., Thomas, Riya, Fardo, David W., Tai, Leon M.
Publicado 2017

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

por Tai, Leon M, Mehra, Shipra, Shete, Varsha, Estus, Steve, Rebeck, G William, Bu, Guojun, LaDu, Mary Jo
Publicado 2014

Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease

por Thomas, Riya, Zimmerman, Scott D., Yuede, Kayla M., Cirrito, John R., Tai, Leon M., Timson, Benjamin F., Yuede, Carla M.
Publicado 2020

LPC-DHA/EPA-Enriched Diets Increase Brain DHA and Modulate Behavior in Mice That Express Human APOE4

por Scheinman, Sarah B., Sugasini, Dhavamani, Zayed, Monay, Yalagala, Poorna C. R., Marottoli, Felecia M., Subbaiah, Papasani V., Tai, Leon M.
Publicado 2021

Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice

por Thomas, Riya, Zuchowska, Paulina, Morris, Alan W. J., Marottoli, Felecia M., Sunny, Sangeeta, Deaton, Ryan, Gann, Peter H., Tai, Leon M.
Publicado 2016

Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human APOE4

por Scheinman, Sarah B., Zaldua, Steve, Dada, Adedoyin, Krochmaliuk, Kateryna, Dye, Katherine, Marottoli, Felecia M., Thatcher, Gregory R. J., Tai, Leon M.
Publicado 2021

A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice

por Balu, Deebika, Valencia-Olvera, Ana C., Nguyen, Austin, Patnam, Mehul, York, Jason, Peri, Francesco, Neumann, Frank, LaDu, Mary Jo, Tai, Leon M.
Publicado 2023

Autocrine Effects of Brain Endothelial Cell-Produced Human Apolipoprotein E on Metabolism and Inflammation in vitro

por Marottoli, Felecia M., Trevino, Troy N., Geng, Xue, Arbieva, Zarema, Kanabar, Pinal, Maienschein-Cline, Mark, Lee, James C., Lutz, Sarah E., Tai, Leon M.
Publicado 2021

APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice

por Balu, Deebika, Valencia-Olvera, Ana C., Islam, Zarak, Mielczarek, Clare, Hansen, Allison, Perez Ramos, Tamara M., York, Jason, LaDu, Mary Jo, Tai, Leon M.
Publicado 2023

Murine Gut Microbiome Association With APOE Alleles

por Parikh, Ishita J., Estus, Janice L., Zajac, Diana J., Malik, Manasi, Maldonado Weng, Juan, Tai, Leon M., Chlipala, George E., LaDu, Mary Jo, Green, Stefan J., Estus, Steven
Publicado 2020

Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction

por Zaldua, Steve, Damen, Frederick C., Pisharody, Rohan, Thomas, Riya, Fan, Kelly D., Ekkurthi, Giri K., Scheinman, Sarah B., Alahmadi, Sami, Marottoli, Felecia M., Alford, Simon, Cai, Kejia, Tai, Leon M.
Publicado 2020

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

por Kruse, Kevin, Lee, Quinn S., Sun, Ying, Klomp, Jeff, Yang, Xiaoyan, Huang, Fei, Sun, Mitchell Y., Zhao, Shuangping, Hong, Zhigang, Vogel, Stephen M., Shin, Jae-Won, Leckband, Deborah E., Tai, Leon M., Malik, Asrar B., Komarova, Yulia A.
Publicado 2019

APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

por Tai, Leon M., Ghura, Shivesh, Koster, Kevin P., Liakaite, Vaiva, Maienschein‐Cline, Mark, Kanabar, Pinal, Collins, Nicole, Ben‐Aissa, Manel, Lei, Arden Zhengdeng, Bahroos, Neil, Green, Stefan J., Hendrickson, Bill, Van Eldik, Linda J., LaDu, Mary Jo
Publicado 2015

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

por Youmans, Katherine L, Tai, Leon M, Kanekiyo, Takahisa, Stine, W Blaine, Michon, Sara-Claude, Nwabuisi-Heath, Evelyn, Manelli, Arlene M, Fu, Yifan, Riordan, Sean, Eimer, William A, Binder, Lester, Bu, Guojun, Yu, Chunjiang, Hartley, Dean M, LaDu, Mary Jo
Publicado 2012