Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?

por Zhan, Wei, Muhuri, Manish, Tai, Phillip W. L., Gao, Guangping
Publicado 2021

Viral vector platforms within the gene therapy landscape

por Bulcha, Jote T., Wang, Yi, Ma, Hong, Tai, Phillip W. L., Gao, Guangping
Publicado 2021

Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses

por Yoon, Yeonsoo, Wang, Dan, Tai, Phillip W. L., Riley, Joy, Gao, Guangping, Rivera-Pérez, Jaime A.
Publicado 2018

Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation

por Tai, Phillip W. L., Wu, Hai, van Wijnen, André J., Stein, Gary S., Stein, Janet L., Lian, Jane B.
Publicado 2017

Querying Recombination Junctions of Replication-Competent Adeno-Associated Viruses in Gene Therapy Vector Preparations with Single Molecule, Real-Time Sequencing

por Yip, Mitchell, Chen, Jing, Zhi, Yan, Tran, Ngoc Tam, Namkung, Suk, Pastor, Eric, Gao, Guangping, Tai, Phillip W. L.
Publicado 2023

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

por Yang, Yeon-Suk, Xie, Jun, Wang, Dan, Kim, Jung-Min, Tai, Phillip W. L., Gravallese, Ellen, Gao, Guangping, Shim, Jae-Hyuck
Publicado 2019

Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras

por Tai, Phillip W.L., Xie, Jun, Fong, Kaiyuen, Seetin, Matthew, Heiner, Cheryl, Su, Qin, Weiand, Michael, Wilmot, Daniella, Zapp, Maria L., Gao, Guangping
Publicado 2018

Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus

por Wang, Dan, Niu, Yuyu, Ren, Lingzhi, Kang, Yu, Tai, Phillip W. L., Si, Chenyang, Mendonca, Craig A., Ma, Hong, Gao, Guangping, Ji, Weizhi
Publicado 2019

Rational engineering of a functional CpG-free ITR for AAV gene therapy

por Pan, Xiufang, Yue, Yongping, Boftsi, Maria, Wasala, Lakmini P., Tran, Ngoc Tam, Zhang, Keqing, Pintel, David J., Tai, Phillip W. L., Duan, Dongsheng
Publicado 2022

Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs

por Lu, Yi, Tai, Phillip W.L., Ai, Jianzhong, Gessler, Dominic J., Su, Qin, Yao, Xieyi, Zheng, Qiang, Zamore, Phillip D., Xu, Xun, Gao, Guangping
Publicado 2018

Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis

por Wu, Hai, Whitfield, Troy W, Gordon, Jonathan A R, Dobson, Jason R, Tai, Phillip W L, van Wijnen, Andre J, Stein, Janet L, Stein, Gary S, Lian, Jane B
Publicado 2014

Efficacious, safe, and stable inhibition of corneal neovascularization by AAV-vectored anti-VEGF therapeutics

por Su, Wenqi, Sun, Shuo, Tian, Bo, Tai, Phillip W.L., Luo, Yongwen, Ko, Jihye, Zhan, Wei, Ke, Xiao, Zheng, Qiang, Li, Xiaorong, Yan, Hua, Gao, Guangping, Lin, Haijiang
Publicado 2021

Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy

por Yang, Yeon-Suk, Xie, Jun, Chaugule, Sachin, Wang, Dan, Kim, Jung-Min, Kim, JiHea, Tai, Phillip W.L., Seo, Seok-kyo, Gravallese, Ellen, Gao, Guangping, Shim, Jae-Hyuck
Publicado 2020

Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis

por Cheng, Shun-Yun, Luo, Yongwen, Malachi, Anneliese, Ko, Jihye, Su, Qin, Xie, Jun, Tian, Bo, Lin, Haijiang, Ke, Xiao, Zheng, Qiang, Tai, Phillip W.L., Gao, Guangping, Punzo, Claudio
Publicado 2021

AAV-Genome Population Sequencing of Vectors Packaging CRISPR Components Reveals Design-Influenced Heterogeneity

por Tran, Ngoc Tam, Heiner, Cheryl, Weber, Kristina, Weiand, Michael, Wilmot, Daniella, Xie, Jun, Wang, Dan, Brown, Alexander, Manokaran, Sangeetha, Su, Qin, Zapp, Maria L., Gao, Guangping, Tai, Phillip W.L.
Publicado 2020

The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter

por Barutcu, A. Rasim, Tai, Phillip W. L., Wu, Hai, Gordon, Jonathan A. R., Whitfield, Troy W., Dobson, Jason R., Imbalzano, Anthony N., Lian, Jane B., van Wijnen, André J., Stein, Janet L., Stein, Gary S.
Publicado 2014

Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

por Muhuri, Manish, Zhan, Wei, Maeda, Yukiko, Li, Jia, Lotun, Anoushka, Chen, Jennifer, Sylvia, Katelyn, Dasgupta, Ishani, Arjomandnejad, Motahareh, Nixon, Thomas, Keeler, Allison M., Manokaran, Sangeetha, He, Ran, Su, Qin, Tai, Phillip W. L., Gao, Guangping
Publicado 2021

Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties

por Hsu, Hung-Lun, Brown, Alexander, Loveland, Anna B., Lotun, Anoushka, Xu, Meiyu, Luo, Li, Xu, Guangchao, Li, Jia, Ren, Lingzhi, Su, Qin, Gessler, Dominic J., Wei, Yuquan, Tai, Phillip W. L., Korostelev, Andrei A., Gao, Guangping
Publicado 2020

Diseases caused by different mutations in the two alleles of a gene are treated in mice by Cas-9-induced allelic exchange.: Cas9-mediated allelic exchange repairs compound heterozy...

por Wang, Dan, Li, Jia, Song, Chun-Qing, Tran, Karen, Mou, Haiwei, Wu, Pei-Hsuan, Tai, Phillip W.L., Mendonca, Craig A., Ren, Lingzhi, Wang, Blake Y., Su, Qin, Gessler, Dominic J., Zamore, Phillip D., Xue, Wen, Gao, Guangping
Publicado 2018

Large-scale molecular epidemiological analysis of AAV in a cancer patient population

por Qin, Wanru, Xu, Guangchao, Tai, Phillip W.L., Wang, Chunmei, Luo, Li, Li, Chengjian, Hu, Xun, Xue, Jianxin, Lu, You, Zhou, Qiao, Wei, Qiang, Wen, Tianfu, Hu, Jiankun, Xiao, Yuanyuan, Yang, Li, Li, Weimin, Flotte, Terence R., Wei, Yuquan, Gao, Guangping
Publicado 2021