The Pursuit of the “Inside” of the Amyloid Hypothesis—Is C99 a Promising Therapeutic Target for Alzheimer’s Disease?

por Takasugi, Nobumasa, Komai, Masato, Kaneshiro, Nanaka, Ikeda, Atsuya, Kamikubo, Yuji, Uehara, Takashi
Publicado 2023

Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage

por Kamikubo, Yuji, Jin, Hao, Zhou, Yiyao, Niisato, Kazue, Hashimoto, Yoshie, Takasugi, Nobumasa, Sakurai, Takashi
Publicado 2023

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

por Takasugi, Nobumasa, Sasaki, Tomoki, Ebinuma, Ihori, Osawa, Satoko, Isshiki, Hayato, Takeo, Koji, Tomita, Taisuke, Iwatsubo, Takeshi
Publicado 2013

The Emerging Role of Electrophiles as a Key Regulator for Endoplasmic Reticulum (ER) Stress

por Takasugi, Nobumasa, Hiraoka, Hideki, Nakahara, Kengo, Akiyama, Shiori, Fujikawa, Kana, Nomura, Ryosuke, Furuichi, Moeka, Uehara, Takashi
Publicado 2019

Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain

por Nomura, Ryosuke, Takasugi, Nobumasa, Hiraoka, Hideki, Iijima, Yuta, Iwawaki, Takao, Kumagai, Yoshito, Fujimura, Masatake, Uehara, Takashi
Publicado 2022

Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor

por Nakahara, Kengo, Hamada, Kyohei, Tsuchida, Tomoki, Takasugi, Nobumasa, Abiko, Yumi, Shien, Kazuhiko, Toyooka, Shinichi, Kumagai, Yoshito, Uehara, Takashi
Publicado 2021

TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes

por Takasugi, Nobumasa, Araya, Runa, Kamikubo, Yuji, Kaneshiro, Nanaka, Imaoka, Ryosuke, Jin, Hao, Kashiyama, Taku, Hashimoto, Yoshie, Kurosawa, Masaru, Uehara, Takashi, Nukina, Nobuyuki, Sakurai, Takashi
Publicado 2018

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

por Kaneshiro, Nanaka, Komai, Masato, Imaoka, Ryosuke, Ikeda, Atsuya, Kamikubo, Yuji, Saito, Takashi, Saido, Takaomi C., Tomita, Taisuke, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Sakurai, Takashi, Uehara, Takashi, Takasugi, Nobumasa
Publicado 2022

Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

por Okuda, Kosaku, Nakahara, Kengo, Ito, Akihiro, Iijima, Yuta, Nomura, Ryosuke, Kumar, Ashutosh, Fujikawa, Kana, Adachi, Kazuya, Shimada, Yuki, Fujio, Satoshi, Yamamoto, Reina, Takasugi, Nobumasa, Onuma, Kunishige, Osaki, Mitsuhiko, Okada, Futoshi, Ukegawa, Taichi, Takeuchi, Yasuo, Yasui, Norihisa, Yamashita, Atsuko, Marusawa, Hiroyuki, Matsushita, Yosuke, Katagiri, Toyomasa, Shibata, Takahiro, Uchida, Koji, Niu, Sheng-Yong, Lang, Nhi B., Nakamura, Tomohiro, Zhang, Kam Y. J., Lipton, Stuart A., Uehara, Takashi
Publicado 2023