Tau Propagation as a Diagnostic and Therapeutic Target for Dementia: Potentials and Unanswered Questions

por Takeda, Shuko
Publicado 2019

Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

por Takeda, Shuko, Sato, Naoyuki, Morishita, Ryuichi
Publicado 2014

Peripheral Aβ acts as a negative modulator of insulin secretion

por Shigemori, Keiko, Nomura, Sachiko, Umeda, Tomohiro, Takeda, Shuko, Tomiyama, Takami
Publicado 2022

Effect of heat stress on blood-brain barrier integrity in iPS cell-derived microvascular endothelial cell models

por Yamaguchi, Tomoko, Shimizu, Kentaro, Kokubu, Yasuhiro, Nishijima, Misae, Takeda, Shuko, Ogura, Hiroshi, Kawabata, Kenji
Publicado 2019

Early detection of cognitive impairment by natural language among outpatients and community dwellers

por Kiyoshige, Eri, Kabayama, Mai, Takeya, Yasushi, Takami, Yoichi, Takeda, Shuko, Gondo, Yasuyuki, Rakugi, Hiromi, Kamide, Kei
Publicado 2020

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

por Zoltowska, Katarzyna Marta, Maesako, Masato, Lushnikova, Iryna, Takeda, Shuko, Keller, Laura J., Skibo, Galina, Hyman, Bradley T., Berezovska, Oksana
Publicado 2017

A novel chronic dural port platform for continuous collection of cerebrospinal fluid and intrathecal drug delivery in free-moving mice

por Nakajima, Tsuneo, Takeda, Shuko, Ito, Yuki, Oyama, Akane, Takami, Yoichi, Takeya, Yasushi, Yamamoto, Koichi, Sugimoto, Ken, Shimizu, Hideo, Shimamura, Munehisa, Rakugi, Hiromi, Morishita, Ryuichi
Publicado 2022

Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

por Sato, Naoyuki, Okochi, Masayasu, Shinohara, Mitsuru, Thinakaran, Gopal, Takeda, Shuko, Fukumori, Akio, Shinohara-Noma, Motoko, Mori-Ueda, Mari, Hamada, Hizuki, Takeda, Masatoshi, Rakugi, Hiromi, Morishita, Ryuichi
Publicado 2012

Correction: Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

por Sato, Naoyuki, Okochi, Masayasu, Shinohara, Mitsuru, Thinakaran, Gopal, Takeda, Shuko, Fukumori, Akio, Shinohara-Noma, Motoko, Mori-Ueda, Mari, Hamada, Hizuki, Takeda, Masatoshi, Rakugi, Hiromi, Morishita, Ryuichi
Publicado 2012

Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts

por György, Bence, Cruz, Lilian, Yellen, David, Aufiero, Massimo, Alland, Isabel, Zhang, Xuan, Ericsson, Maria, Fraefel, Cornel, Li, Yu-Ching, Takeda, Shuko, Hyman, Bradley T., Breakefield, Xandra O.
Publicado 2018

Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology

por Oyama, Akane, Takeda, Shuko, Ito, Yuki, Nakajima, Tsuneo, Takami, Yoichi, Takeya, Yasushi, Yamamoto, Koichi, Sugimoto, Ken, Shimizu, Hideo, Shimamura, Munehisa, Katayama, Taiichi, Rakugi, Hiromi, Morishita, Ryuichi
Publicado 2019

Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease

por Shinohara, Mitsuru, Kikuchi, Masataka, Onishi‐Takeya, Miyuki, Tashiro, Yoshitaka, Suzuki, Kaoru, Noda, Yasuhiro, Takeda, Shuko, Mukouzono, Masahiro, Nagano, Seiichi, Fukumori, Akio, Morishita, Ryuichi, Nakaya, Akihiro, Sato, Naoyuki
Publicado 2021

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells

por Gustafsson, Gabriel, Lööv, Camilla, Persson, Emma, Lázaro, Diana F., Takeda, Shuko, Bergström, Joakim, Erlandsson, Anna, Sehlin, Dag, Balaj, Leonora, György, Bence, Hallbeck, Martin, Outeiro, Tiago F., Breakefield, Xandra O., Hyman, Bradley T., Ingelsson, Martin
Publicado 2018

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

por Nicholls, Samantha B., DeVos, Sarah L., Commins, Caitlin, Nobuhara, Chloe, Bennett, Rachel E., Corjuc, Diana L., Maury, Eduardo, Eftekharzadeh, Bahareh, Akingbade, Ololade, Fan, Zhanyun, Roe, Allyson D., Takeda, Shuko, Wegmann, Susanne, Hyman, Bradley T.
Publicado 2017

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

por György, Bence, Lööv, Camilla, Zaborowski, Mikołaj P., Takeda, Shuko, Kleinstiver, Benjamin P., Commins, Caitlin, Kastanenka, Ksenia, Mu, Dakai, Volak, Adrienn, Giedraitis, Vilmantas, Lannfelt, Lars, Maguire, Casey A., Joung, J. Keith, Hyman, Bradley T., Breakefield, Xandra O., Ingelsson, Martin
Publicado 2018

Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology

por Kastanenka, Ksenia V., Calvo-Rodriguez, Maria, Hou, Steven S., Zhou, Heng, Takeda, Shuko, Arbel-Ornath, Michal, Lariviere, Amanda, Lee, Yee Fun, Kim, Alex, Hawkes, Jonathan M., Logan, Robert, Feng, Danielle, Chen, Xiqun, Gomperts, Stephen N., Bacskai, Brian J.
Publicado 2019

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

por Takeda, Shuko, Wegmann, Susanne, Cho, Hansang, DeVos, Sarah L., Commins, Caitlin, Roe, Allyson D., Nicholls, Samantha B., Carlson, George A., Pitstick, Rose, Nobuhara, Chloe K., Costantino, Isabel, Frosch, Matthew P., Müller, Daniel J., Irimia, Daniel, Hyman, Bradley T.
Publicado 2015

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

por Arbel-Ornath, Michal, Hudry, Eloise, Boivin, Josiah R., Hashimoto, Tadafumi, Takeda, Shuko, Kuchibhotla, Kishore V., Hou, Steven, Lattarulo, Carli R., Belcher, Arianna M., Shakerdge, Naomi, Trujillo, Pariss B., Muzikansky, Alona, Betensky, Rebecca A., Hyman, Bradley T., Bacskai, Brian J.
Publicado 2017

RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS

por Shimizu, Mikito, Shiraishi, Naoyuki, Tada, Satoru, Sasaki, Tsutomu, Beck, Goichi, Nagano, Seiichi, Kinoshita, Makoto, Sumi, Hisae, Sugimoto, Tomoyuki, Ishida, Yoko, Koda, Toru, Ishikura, Teruyuki, Sugiyama, Yasuko, Kihara, Keigo, Kanakura, Minami, Nakajima, Tsuneo, Takeda, Shuko, Takahashi, Masanori P., Yamashita, Toshihide, Okuno, Tatsusada, Mochizuki, Hideki
Publicado 2023

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

por Amaral, Ana Claudia, Perez-Nievas, Beatriz G., Siao Tick Chong, Michael, Gonzalez-Martinez, Alicia, Argente-Escrig, Herminia, Rubio-Guerra, Sara, Commins, Caitlin, Muftu, Serra, Eftekharzadeh, Bahareh, Hudry, Eloise, Fan, Zhanyun, Ramanan, Prianca, Takeda, Shuko, Frosch, Matthew P., Wegmann, Susanne, Gomez-Isla, Teresa
Publicado 2021