Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

por Takita, Hiroyuki, Darwich, Adam S., Ahmad, Amais, Rostami‐Hodjegan, Amin
Publicado 2020

Physiologically‐Based Pharmacokinetic Modelling of Creatinine‐Drug Interactions in the Chronic Kidney Disease Population

por Takita, Hiroyuki, Scotcher, Daniel, Chinnadurai, Rajkumar, Kalra, Philip A., Galetin, Aleksandra
Publicado 2020

Coproporphyrin I as an Endogenous Biomarker to Detect Reduced OATP1B Activity and Shift in Elimination Route in Chronic Kidney Disease

por Takita, Hiroyuki, Scotcher, Daniel, Chu, Xiaoyan, Yee, Ka Lai, Ogungbenro, Kayode, Galetin, Aleksandra
Publicado 2022

PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

por Takita, Hiroyuki, Barnett, Shelby, Zhang, Yueping, Ménochet, Karelle, Shen, Hong, Ogungbenro, Kayode, Galetin, Aleksandra
Publicado 2021

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

por Murata, Yukiko, Neuhoff, Sibylle, Rostami-Hodjegan, Amin, Takita, Hiroyuki, Al-Majdoub, Zubida M., Ogungbenro, Kayode
Publicado 2022

Differences in the flexion and extension phases during kneeling investigated by kinematic and contact point analyses: a cross-sectional study

por Nakazoe, Yusuke, Yonekura, Akihiko, Takita, Hiroyuki, Miyaji, Takeshi, Okazaki, Narihiro, Chiba, Ko, Kidera, Kenichi, Miyamoto, Takashi, Tomita, Masato, Gamada, Kazuyoshi, Osaki, Makoto
Publicado 2022

Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase

por Morita, Junko, Kano, Kuniyuki, Kato, Kazuki, Takita, Hiroyuki, Sakagami, Hideki, Yamamoto, Yasuo, Mihara, Emiko, Ueda, Hirofumi, Sato, Takanao, Tokuyama, Hidetoshi, Arai, Hiroyuki, Asou, Hiroaki, Takagi, Junichi, Ishitani, Ryuichiro, Nishimasu, Hiroshi, Nureki, Osamu, Aoki, Junken
Publicado 2016