Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: rationale for lower dosage in Asia

por Zhou, Xiaofei, Mould, Diane R., Takubo, Takatoshi, Sheldon‐Waniga, Emily, Huebner, Dirk, Milton, Ashley, Venkatakrishnan, Karthik
Publicado 2017

Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors

por Doi, Toshihiko, Ohtsu, Atsushi, Fuse, Nozomu, Yoshino, Takayuki, Tahara, Makoto, Shibayama, Kazuhiro, Takubo, Takatoshi, Weinreich, David M.
Publicado 2012

A phase 1 multiple-dose study of orteronel in Japanese patients with castration-resistant prostate cancer

por Suzuki, Kazuhiro, Ozono, Seiichiro, Yamaguchi, Akito, Koike, Hidekazu, Matsui, Hiroshi, Nagata, Masao, Takubo, Takatoshi, Miyashita, Kana, Matsushima, Takafumi, Akaza, Hideyuki
Publicado 2014

Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tum...

por Murakami, Haruyasu, Doi, Toshihiko, Yamamoto, Nobuyuki, Watanabe, Junichiro, Boku, Narikazu, Fuse, Nozomu, Yoshino, Takayuki, Ohtsu, Atsushi, Otani, Satoru, Shibayama, Kazuhiro, Takubo, Takatoshi, Loh, Elwyn
Publicado 2012

Phase I / II study of brentuximab vedotin in Japanese patients with relapsed or refractory CD30-positive Hodgkin's lymphoma or systemic anaplastic large-cell lymphoma

por Ogura, Michinori, Tobinai, Kensei, Hatake, Kiyohiko, Ishizawa, Kenichi, Uike, Naokuni, Uchida, Toshiki, Suzuki, Tatsuya, Aoki, Tomohiro, Watanabe, Takashi, Maruyama, Dai, Yokoyama, Masahiro, Takubo, Takatoshi, Kagehara, Hideaki, Matsushima, Takafumi
Publicado 2014