Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

por Talanian, Robert V., Yang, XiaoHe, Turbov, Jane, Seth, Prem, Ghayur, Tariq, Casiano, Carlos A., Orth, Kim, Froelich, Christopher J.
Publicado 1997

Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

por Biber, Knut, Bhattacharya, Anindya, Campbell, Brian M., Piro, Justin R., Rohe, Michael, Staal, Roland G.W., Talanian, Robert V., Möller, Thomas
Publicado 2019

MEK1/2 activity modulates TREM2 cell surface recruitment

por Schapansky, Jason, Grinberg, Yelena Y., Osiecki, David M., Freeman, Emily A., Walker, Stephen G., Karran, Eric, Gopalakrishnan, Sujatha M., Talanian, Robert V.
Publicado 2020

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis

por Ghayur, Tariq, Hugunin, Margaret, Talanian, Robert V., Ratnofsky, Sheldon, Quinlan, Christopher, Emoto, Yutaka, Pandey, Pramod, Datta, Rakesh, Huang, Yinyin, Kharbanda, Surender, Allen, Hamish, Kamen, Robert, Wong, Winnie, Kufe, Donald
Publicado 1996

Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

por Duan, Lishu, Hu, Mufeng, Tamm, Joseph A., Grinberg, Yelena Y., Shen, Fang, Chai, Yating, Xi, Hualin, Gibilisco, Lauren, Ravikumar, Brinda, Gautam, Vivek, Karran, Eric, Townsend, Matthew, Talanian, Robert V.
Publicado 2021

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease

por Das, Sudeshna, Li, Zhaozhi, Wachter, Astrid, Alla, Srinija, Noori, Ayush, Abdourahman, Aicha, Tamm, Joseph A., Woodbury, Maya E., Talanian, Robert V., Biber, Knut, Karran, Eric H., Hyman, Bradley T., Serrano-Pozo, Alberto
Publicado 2023

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease

por Bryant, Annie, Li, Zhaozhi, Jayakumar, Rojashree, Serrano-Pozo, Alberto, Woost, Benjamin, Hu, Miwei, Woodbury, Maya E., Wachter, Astrid, Lin, Gen, Kwon, Taekyung, Talanian, Robert V., Biber, Knut, Karran, Eric H., Hyman, Bradley T., Das, Sudeshna, Bennett, Rachel E.
Publicado 2023

Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

por Argiriadi, Maria A, Sousa, Silvino, Banach, David, Marcotte, Douglas, Xiang, Tao, Tomlinson, Medha J, Demers, Megan, Harris, Christopher, Kwak, Silvia, Hardman, Jennifer, Pietras, Margaret, Quinn, Lisa, DiMauro, Jennifer, Ni, Baofu, Mankovich, John, Borhani, David W, Talanian, Robert V, Sadhukhan, Ramkrishna
Publicado 2009

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

por Argiriadi, Maria A, Goedken, Eric R, Banach, David, Borhani, David W, Burchat, Andrew, Dixon, Richard W, Marcotte, Doug, Overmeyer, Gary, Pivorunas, Valerie, Sadhukhan, Ramkrishna, Sousa, Silvino, Moore, Nigel St John, Tomlinson, Medha, Voss, Jeffrey, Wang, Lu, Wishart, Neil, Woller, Kevin, Talanian, Robert V
Publicado 2012