Heat shock protein 90 in neurodegenerative diseases

por Luo, Wenjie, Sun, Weilin, Taldone, Tony, Rodina, Anna, Chiosis, Gabriela
Publicado 2010

A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90)

por Shahinas, Dea, Folefoc, Asongna, Taldone, Tony, Chiosis, Gabriela, Crandall, Ian, Pillai, Dylan R.
Publicado 2013

Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using (89)Zr-DFO-Trastuzumab

por Holland, Jason P., Caldas-Lopes, Eloisi, Divilov, Vadim, Longo, Valerie A., Taldone, Tony, Zatorska, Danuta, Chiosis, Gabriela, Lewis, Jason S.
Publicado 2010

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

por Taldone, Tony, Gillan, Victoria, Sun, Weilin, Rodina, Anna, Patel, Pallav, Maitland, Kirsty, O'Neill, Kerry, Chiosis, Gabriela, Devaney, Eileen
Publicado 2010

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

por Taldone, Tony, Rodina, Anna, DaGama Gomes, Erica M, Riolo, Matthew, Patel, Hardik J, Alonso-Sabadell, Raul, Zatorska, Danuta, Patel, Maulik R, Kishinevsky, Sarah, Chiosis, Gabriela
Publicado 2013

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

por Kang, Yanlong, Taldone, Tony, Patel, Hardik J., Patel, Pallav D., Rodina, Anna, Gozman, Alexander, Maharaj, Ronnie, Clement, Cristina C., Patel, Maulik R., Brodsky, Jeffrey L., Young, Jason C., Chiosis, Gabriela
Publicado 2014

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an All...

por Taldone, Tony, Kang, Yanlong, Patel, Hardik J., Patel, Maulik R., Patel, Pallav D., Rodina, Anna, Patel, Yogita, Gozman, Alexander, Maharaj, Ronnie, Clement, Cristina C., Lu, Alvin, Young, Jason C., Chiosis, Gabriela
Publicado 2014

Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

por Beebe, Kristin, Mollapour, Mehdi, Scroggins, Bradley, Prodromou, Chrisostomos, Xu, Wanping, Tokita, Mari, Taldone, Tony, Pullen, Lester, Zierer, Bettina K., Lee, Min-Jung, Trepel, Jane, Buchner, Johannes, Bolon, Daniel, Chiosis, Gabriela, Neckers, Leonard
Publicado 2013

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

por Chung, Sun Young, Kishinevsky, Sarah, Mazzulli, Joseph R., Graziotto, John, Mrejeru, Ana, Mosharov, Eugene V., Puspita, Lesly, Valiulahi, Parvin, Sulzer, David, Milner, Teresa A., Taldone, Tony, Krainc, Dimitri, Studer, Lorenz, Shim, Jae-won
Publicado 2016

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

por Zong, Hongliang, Gozman, Alexander, Caldas-Lopes, Eloisi, Taldone, Tony, Sturgill, Eric, Brennan, Sarah, Ochiana, Stefan O., Gomes-DaGama, Erica M., Sen, Siddhartha, Rodina, Anna, Koren, John, Becker, Michael W., Rudin, Charles M., Melnick, Ari, Levine, Ross L., Roboz, Gail J., Nimer, Stephen D., Chiosis, Gabriela, Guzman, Monica L.
Publicado 2015

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas

por Calvo-Vidal, M. Nieves, Zamponi, Nahuel, Krumsiek, Jan, Stockslager, Max A., Revuelta, Maria V., Phillip, Jude M., Marullo, Rossella, Tikhonova, Ekaterina, Kotlov, Nikita, Patel, Jayeshkumar, Yang, Shao Ning, Yang, Lucy, Taldone, Tony, Thieblemont, Catherine, Leonard, John P., Martin, Peter, Inghirami, Giorgio, Chiosis, Gabriela, Manalis, Scott R., Cerchietti, Leandro
Publicado 2021

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

por Rodina, Anna, Taldone, Tony, Kang, Yanlong, Patel, Pallav D., Koren, John, Yan, Pengrong, DaGama Gomes, Erica M., Yang, Chenghua, Patel, Maulik R., Shrestha, Liza, Ochiana, Stefan O., Santarossa, Cristina, Maharaj, Ronnie, Gozman, Alexander, Cox, Marc B., Erdjument-Bromage, Hediye, Hendrickson, Ronald C., Cerchietti, Leandro, Melnick, Ari, Guzman, Monica L., Chiosis, Gabriela
Publicado 2014

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

por Kishinevsky, Sarah, Wang, Tai, Rodina, Anna, Chung, Sun Young, Xu, Chao, Philip, John, Taldone, Tony, Joshi, Suhasini, Alpaugh, Mary L., Bolaender, Alexander, Gutbier, Simon, Sandhu, Davinder, Fattahi, Faranak, Zimmer, Bastian, Shah, Smit K., Chang, Elizabeth, Inda, Carmen, Koren, John, Saurat, Nathalie G., Leist, Marcel, Gross, Steven S., Seshan, Venkatraman E., Klein, Christine, Tomishima, Mark J., Erdjument-Bromage, Hediye, Neubert, Thomas A., Henrickson, Ronald C., Chiosis, Gabriela, Studer, Lorenz
Publicado 2018

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

por Rodina, Anna, Xu, Chao, Digwal, Chander S., Joshi, Suhasini, Patel, Yogita, Santhaseela, Anand R., Bay, Sadik, Merugu, Swathi, Alam, Aftab, Yan, Pengrong, Yang, Chenghua, Roychowdhury, Tanaya, Panchal, Palak, Shrestha, Liza, Kang, Yanlong, Sharma, Sahil, Almodovar, Justina, Corben, Adriana, Alpaugh, Mary L., Modi, Shanu, Guzman, Monica L., Fei, Teng, Taldone, Tony, Ginsberg, Stephen D., Erdjument-Bromage, Hediye, Neubert, Thomas A., Manova-Todorova, Katia, Tsou, Meng-Fu Bryan, Young, Jason C., Wang, Tai, Chiosis, Gabriela
Publicado 2023

Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

por Bolaender, Alexander, Zatorska, Danuta, He, Huazhong, Joshi, Suhasini, Sharma, Sahil, Digwal, Chander S., Patel, Hardik J., Sun, Weilin, Imber, Brandon S., Ochiana, Stefan O., Patel, Maulik R., Shrestha, Liza, Shah, Smit. K., Wang, Shuo, Karimov, Rashad, Tao, Hui, Patel, Pallav D., Martin, Ananda Rodilla, Yan, Pengrong, Panchal, Palak, Almodovar, Justina, Corben, Adriana, Rimner, Andreas, Ginsberg, Stephen D., Lyashchenko, Serge, Burnazi, Eva, Ku, Anson, Kalidindi, Teja, Lee, Sang Gyu, Grkovski, Milan, Beattie, Bradley J., Zanzonico, Pat, Lewis, Jason S., Larson, Steve, Rodina, Anna, Pillarsetty, Nagavarakishore, Tabar, Viviane, Dunphy, Mark P., Taldone, Tony, Shimizu, Fumiko, Chiosis, Gabriela
Publicado 2021

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

por Inda, Maria Carmen, Joshi, Suhasini, Wang, Tai, Bolaender, Alexander, Gandu, Srinivasa, Koren III, John, Che, Alicia Yue, Taldone, Tony, Yan, Pengrong, Sun, Weilin, Uddin, Mohammad, Panchal, Palak, Riolo, Matthew, Shah, Smit, Barlas, Afsar, Xu, Ke, Chan, Lon Yin L., Gruzinova, Alexandra, Kishinevsky, Sarah, Studer, Lorenz, Fossati, Valentina, Noggle, Scott A., White, Julie R., de Stanchina, Elisa, Sequeira, Sonia, Anthoney, Kyle H., Steele, John W., Manova-Todorova, Katia, Patil, Sujata, Dunphy, Mark P., Pillarsetty, NagaVaraKishore, Pereira, Ana C., Erdjument-Bromage, Hediye, Neubert, Thomas A., Rodina, Anna, Ginsberg, Stephen D., De Marco Garcia, Natalia, Luo, Wenjie, Chiosis, Gabriela
Publicado 2020

Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

por Joshi, Suhasini, Gomes, Erica DaGama, Wang, Tai, Corben, Adriana, Taldone, Tony, Gandu, Srinivasa, Xu, Chao, Sharma, Sahil, Buddaseth, Salma, Yan, Pengrong, Chan, Lon Yin L., Gokce, Askan, Rajasekhar, Vinagolu K., Shrestha, Lisa, Panchal, Palak, Almodovar, Justina, Digwal, Chander S., Rodina, Anna, Merugu, Swathi, Pillarsetty, NagaVaraKishore, Miclea, Vlad, Peter, Radu I., Wang, Wanyan, Ginsberg, Stephen D., Tang, Laura, Mattar, Marissa, de Stanchina, Elisa, Yu, Kenneth H., Lowery, Maeve, Grbovic-Huezo, Olivera, O’Reilly, Eileen M., Janjigian, Yelena, Healey, John H., Jarnagin, William R., Allen, Peter J., Sander, Chris, Erdjument-Bromage, Hediye, Neubert, Thomas A., Leach, Steven D., Chiosis, Gabriela
Publicado 2021