GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR

por Bernadyn, Tyler F., Vizurraga, Alexander, Adhikari, Rashmi, Kwarcinski, Frank, Tall, Gregory G.
Publicado 2023

Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56

por Vizurraga, Alexander L., Robertson, Michael J., Yu, Maiya, Skiniotis, Georgios, Tall, Gregory G.
Publicado 2023

The Nucleotide Exchange Factor Ric-8A Is a Chaperone for the Conformationally Dynamic Nucleotide-Free State of Gαi1

por Thomas, Celestine J., Briknarová, Klára, Hilmer, Jonathan K., Movahed, Navid, Bothner, Brian, Sumida, John P., Tall, Gregory G., Sprang, Stephen R.
Publicado 2011

Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms

por Seven, Alpay Burak, Hilger, Daniel, Papasergi-Scott, Makaía M., Zhang, Li, Qu, Qianhui, Kobilka, Brian K., Tall, Gregory G., Skiniotis, Georgios
Publicado 2020

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics

por Tourdot, Benjamin E., Stoveken, Hannah, Trumbo, Derek, Yeung, Jennifer, Kanthi, Yogendra, Edelstein, Leonard C., Bray, Paul F., Tall, Gregory G., Holinstat, Michael
Publicado 2018

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

por Yeung, Jennifer, Adili, Reheman, Stringham, Emily N., Luo, Rong, Vizurraga, Alexander, Rosselli-Murai, Luciana K., Stoveken, Hannah M., Yu, Maiya, Piao, Xianhua, Holinstat, Michael, Tall, Gregory G.
Publicado 2020

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

por Giera, Stefanie, Luo, Rong, Ying, Yanqin, Ackerman, Sarah D, Jeong, Sung-Jin, Stoveken, Hannah M, Folts, Christopher J, Welsh, Christina A, Tall, Gregory G, Stevens, Beth, Monk, Kelly R, Piao, Xianhua
Publicado 2018

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

por Mathiasen, Signe, Palmisano, Tiago, Perry, Nicole A., Stoveken, Hannah M., Vizurraga, Alex, McEwen, Dyke P., Okashah, Najeah, Langenhan, Tobias, Inoue, Asuka, Lambert, Nevin A., Tall, Gregory G., Javitch, Jonathan A.
Publicado 2020

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

por McClelland, Levi J., Zhang, Kaiming, Mou, Tung-Chung, Johnston, Jake, Yates-Hansen, Cindee, Li, Shanshan, Thomas, Celestine J., Doukov, Tzanko I., Triest, Sarah, Wohlkonig, Alexandre, Tall, Gregory G., Steyaert, Jan, Chiu, Wah, Sprang, Stephen R.
Publicado 2020

GPR56/ADGRG1 is associated with response to antidepressant treatment

por Belzeaux, Raoul, Gorgievski, Victor, Fiori, Laura M., Lopez, Juan Pablo, Grenier, Julien, Lin, Rixing, Nagy, Corina, Ibrahim, El Chérif, Gascon, Eduardo, Courtet, Philippe, Richard-Devantoy, Stéphane, Berlim, Marcelo, Chachamovich, Eduardo, Théroux, Jean-François, Dumas, Sylvie, Giros, Bruno, Rotzinger, Susan, Soares, Claudio N., Foster, Jane A., Mechawar, Naguib, Tall, Gregory G., Tzavara, Eleni T., Kennedy, Sidney H., Turecki, Gustavo
Publicado 2020