Dual Roles for Ste24p in Yeast a-Factor Maturation: NH(2)-terminal Proteolysis and COOH-terminal CAAX Processing

por Tam, Amy, Nouvet, Franklin J., Fujimura-Kamada, Konomi, Slunt, Hilda, Sisodia, Sangram S., Michaelis, Susan
Publicado 1998

Dormant spores sense amino acids through the B subunits of their germination receptors

por Artzi, Lior, Alon, Assaf, Brock, Kelly P., Green, Anna G., Tam, Amy, Ramírez-Guadiana, Fernando H., Marks, Debora, Kruse, Andrew, Rudner, David Z.
Publicado 2021

Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics

por Ngo, Kim A., Kishimoto, Kensei, Davis-Turak, Jeremy, Pimplaskar, Aditya, Cheng, Zhang, Spreafico, Roberto, Chen, Emily Y., Tam, Amy, Ghosh, Gourisankar, Mitchell, Simon, Hoffmann, Alexander
Publicado 2020

Exploring Parametric and Mechanistic Differences between Expi293F(TM) and ExpiCHO-S(TM) Cells for Transient Antibody Production Optimization

por Zhou, Jing, Yan, Guoying Grace, Cluckey, David, Meade, Caryl, Ruth, Margaret, Sorm, Rhady, Tam, Amy S., Lim, Sean, Petridis, Constantine, Lin, Laura, D’Antona, Aaron M., Zhong, Xiaotian
Publicado 2023

A search for protein biomarkers links olfactory signal transduction to social immunity

por Guarna, Maria Marta, Melathopoulos, Andony P, Huxter, Elizabeth, Iovinella, Immacolata, Parker, Robert, Stoynov, Nikolay, Tam, Amy, Moon, Kyung-Mee, Chan, Queenie WT, Pelosi, Paolo, White, Rick, Pernal, Stephen F, Foster, Leonard J
Publicado 2015

Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation

por Bone, Ruth, Fennell, Brian J, Tam, Amy, Sheldon, Richard, Nocka, Karl, Varghese, Sreeja, Chang, Chew Shun, Hawerkamp, Heike C, Yeow, Aoife, Saunders, Sean P, Hams, Emily, Walsh, Patrick T, Cunningham, Orla, Fallon, Padraic G
Publicado 2022

Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design

por Apgar, James R., Tam, Amy S. P., Sorm, Rhady, Moesta, Sybille, King, Amy C., Yang, Han, Kelleher, Kerry, Murphy, Denise, D’Antona, Aaron M., Yan, Guoying, Zhong, Xiaotian, Rodriguez, Linette, Ma, Weijun, Ferguson, Darren E., Carven, Gregory J., Bennett, Eric M., Lin, Laura
Publicado 2020

Genetic rearrangement during site specific integration event facilitates cell line development of a bispecific molecule

por Tevelev, Barbara, Patel, Himakshi, Shields, Kathleen, Wei, Wei, Cooley, Cecilia, Zhang, Sam, Bitzas, Gabrielle, Duan, Weili, Khetemenee, Lam, Jackobek, Ryan, D'Antona, Aaron, Sievers, Annette, King, Amy, Tam, Amy, Zhang, Yan, Sousa, Eric, Cohen, Justin, Wroblewska, Lila, Marshall, Jeffrey, Jackson, Martha, Scarcelli, John J.
Publicado 2021

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

por Fung, Ella, Kang, Liya, Sapashnik, Diana, Benard, Susan, Sievers, Annette, Liu, Yan, Yan, Guoying, Zhou, Jing, Rodriguez, Linette, Ma, Weijun, Stochaj, Wayne R., LaVallie, Edward, Wroblewska, Liliana, Kelleher, Kerry, Tam, Amy, Bezy, Olivier, Breen, Danna, Chabot, Jeffrey R., He, Tao, Lin, Laura, Wu, Zhidan, Mosyak, Lidia
Publicado 2021

Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

por Weng, Yan, Ishino, Tetsuya, Sievers, Annette, Talukdar, Saswata, Chabot, Jeffrey R., Tam, Amy, Duan, Weili, Kerns, Kelvin, Sousa, Eric, He, Tao, Logan, Alison, Lee, Darwin, Li, Dongmei, Zhou, Yingjiang, Bernardo, Barbara, Joyce, Alison, Kavosi, Mania, O’Hara, Denise M., Clark, Tracey, Guo, Jie, Giragossian, Craig, Stahl, Mark, Calle, Roberto A., Kriz, Ron, Somers, Will, Lin, Laura
Publicado 2018

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

por Fennell, Brian J, McDonnell, Barry, Tam, Amy Sze Pui, Chang, Lijun, Steven, John, Broadbent, Ian D, Gao, Huilan, Kieras, Elizabeth, Alley, Jennifer, Luxenberg, Deborah, Edmonds, Jason, Fitz, Lori J, Miao, Wenyan, Whitters, Matthew J, Medley, Quintus G, Guo, Yongjing J, Darmanin-Sheehan, Alfredo, Autin, Bénédicte, Shúilleabháin, Deirdre Ní, Cummins, Emma, King, Amy, Krebs, Mark RH, Grace, Christopher, Hickling, Timothy P, Boisvert, Angela, Zhong, Xiaotian, McKenna, Matthew, Francis, Christopher, Olland, Stephane, Bloom, Laird, Paulsen, Janet, Somers, Will, Jensen, Allan, Lin, Laura, Finlay, William JJ, Cunningham, Orla
Publicado 2013

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

por Root, Adam R., Guntas, Gurkan, Katragadda, Madan, Apgar, James R., Narula, Jatin, Chang, Chew Shun, Hanscom, Sara, McKenna, Matthew, Wade, Jason, Meade, Caryl, Ma, Weijun, Guo, Yongjing, Liu, Yan, Duan, Weili, Hendershot, Claire, King, Amy C., Zhang, Yan, Sousa, Eric, Tam, Amy, Benard, Susan, Yang, Han, Kelleher, Kerry, Jin, Fang, Piche-Nicholas, Nicole, Keating, Sinead E., Narciandi, Fernando, Lawrence-Henderson, Rosemary, Arai, Maya, Stochaj, Wayne R., Svenson, Kristine, Mosyak, Lidia, Lam, Khetemcnee, Francis, Christopher, Marquette, Kimberly, Wroblewska, Liliana, Zhu, H. Lily, Sheehan, Alfredo Darmanin, LaVallie, Edward R., D’Antona, Aaron M., Betts, Alison, King, Lindsay, Rosfjord, Edward, Cunningham, Orla, Lin, Laura, Sapra, Puja, Tchistiakova, Lioudmila, Mathur, Divya, Bloom, Laird
Publicado 2021