Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target

por Qin, Bo, Li, Ziheng, Tang, Kaiming, Wang, Tongyun, Xie, Yubin, Aumonier, Sylvain, Wang, Meitian, Yuan, Shuofeng, Cui, Sheng
Publicado 2023

Impact of Pb on Chlamydomonas reinhardtii at Physiological and Transcriptional Levels

por Zheng, Canqi, Aslam, Muhammad, Liu, Xiaojuan, Du, Hong, Xie, Xihui, Jia, Haojie, Huang, Nan, Tang, Kaiming, Yang, Yingquan, Li, Ping
Publicado 2020

Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo

por Li, Mengjiao, Ye, Zi-Wei, Tang, Kaiming, Guo, Liang, Bi, Wenwen, Zhang, Yuyuan, Tang, Yan-dong, Rong, Guoguang, Sawan, Mohamad, Yin, Xin, Sun, Ren, Yuan, Shuofeng, Dang, Bobo
Publicado 2022

Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants

por Ong, Chon Phin, Tang, Kaiming, Cheung, Pak-Hin Hinson, Zhang, Hongzhuo, Tang, Tze-Tung, Xue, Yaqian, Wang, Junjue, To, Kelvin Kai-Wang, Yuan, Shuofeng, Ye, Zi-Wei, Jin, Dong-Yan
Publicado 2023

Effect of Different Adjuvants on Immune Responses Elicited by Protein-Based Subunit Vaccines against SARS-CoV-2 and Its Delta Variant

por Zhang, Naru, Ji, Qianting, Liu, Zezhong, Tang, Kaiming, Xie, Yubin, Li, Kangchen, Zhou, Jie, Li, Sisi, Shang, Haotian, Shi, Zecan, Zheng, Tianyu, Yao, Jiawei, Lu, Lu, Yuan, Shuofeng, Jiang, Shibo
Publicado 2022

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

por Zou, Zijiao, Tsang, Jessica Oi-Ling, Yan, Bingpeng, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Yuen, Kwok-Yung
Publicado 2020

SARS-CoV-2 exploits host DGAT and ADRP for efficient replication

por Yuan, Shuofeng, Yan, Bingpeng, Cao, Jianli, Ye, Zi-Wei, Liang, Ronghui, Tang, Kaiming, Luo, Cuiting, Cai, Jianpiao, Chu, Hin, Chung, Tom Wai-Hing, To, Kelvin Kai-Wang, Hung, Ivan Fan-Ngai, Jin, Dong-Yan, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung
Publicado 2021

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly

por Hu, Bodan, Chik, Kenn Ka-Heng, Chan, Jasper Fuk-Woo, Cai, Jian-Piao, Cao, Hehe, Tsang, Jessica Oi-Ling, Zou, Zijiao, Hung, Yin-Po, Tang, Kaiming, Jia, Lilong, Luo, Cuiting, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Yeung, Man-Lung, Yuan, Shuofeng
Publicado 2022

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

por Yuan, Shuofeng, Chan, Jasper F.W., Chik, Kenn K.H., Chan, Chris C.Y., Tsang, Jessica O.L., Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Chen, Lin-Lei, Wen, Kun, Cai, Jian-Piao, Ye, Zi-Wei, Lu, Gang, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung
Publicado 2020

Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets

por Cao, Jianli, Lu, Gang, Wen, Lei, Luo, Peng, Huang, Yaoqiang, Liang, Ronghui, Tang, Kaiming, Qin, Zhenzhi, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Du, Jiang, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Yuan, Shuofeng
Publicado 2021

Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity

por Zhou, Ying, Yuan, Shuofeng, Xiao, Fan, Li, Hongyan, Ye, Ziwei, Cheng, Tianfan, Luo, Cuiting, Tang, Kaiming, Cai, Jianpiao, Situ, Jianwen, Sridhar, Siddharth, Chu, Wing-Ming, Tam, Anthony Raymond, Chu, Hin, Che, Chi-Ming, Jin, Lijian, Hung, Ivan Fan-Ngai, Lu, Liwei, Chan, Jasper Fuk-Woo, Sun, Hongzhe
Publicado 2023

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

por Yuan, Shuofeng, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, To, Kelvin Kai-Wang, Chu, Hin, Jin, Dong-Yan, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2020

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection

por Ye, Zi-Wei, Yuan, Shuofeng, Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yu, Ching-Yun, Ong, Chon Phin, Yang, Dong, Chan, Chris Chun-Yiu, Tang, Kaiming, Cao, Jianli, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chu, Hin, Yuen, Kwok-Yung, Jin, Dong-Yan
Publicado 2021

In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor

por Wen, Lei, Tang, Kaiming, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Huang, Yaoqiang, Luo, Cuiting, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Yuan, Shuofeng, Chan, Jasper Fuk-Woo
Publicado 2021

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

por Ye, Zi-Wei, Ong, Chon Phin, Tang, Kaiming, Fan, Yilan, Luo, Cuiting, Zhou, Runhong, Luo, Peng, Cheng, Yun, Gray, Victor Sebastien, Wang, Pui, Chu, Hin, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Chen, Honglin, Chen, Zhiwei, Yuen, Kwok-Yung, Ling, Guang Sheng, Yuan, Shuofeng, Jin, Dong-Yan
Publicado 2022

Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection

por Ruan, Degong, Ye, Zi-Wei, Yuan, Shuofeng, Li, Zhuoxuan, Zhang, Weiyu, Ong, Chon Phin, Tang, Kaiming, Ka Ki Tam, Timothy Theodore, Guo, Jilong, Xuan, Yiyi, Huang, Yunying, Zhang, Qingqing, Lee, Cheuk-Lun, Lu, Liming, Chiu, Philip C.N., Yeung, William S.B., Liu, Fang, Jin, Dong-Yan, Liu, Pentao
Publicado 2022

Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines

por Ye, Zi-Wei, Fan, Yilan, Tang, Kaiming, Ong, Chon Phin, Luo, Cuiting, Chung, Hon-Lam, Leong, Tsun-Lam, Liang, Ronghui, Lui, Wai-Yin, Zhou, Runhong, Cheng, Yun, Lu, Lu, Cheung, Pak-Hin Hinson, Chan, Jasper Fuk-Woo, Chen, Zhiwei, Yuen, Kwok-Yung, Yuan, Shuofeng, To, Kelvin Kai-Wang, Jin, Dong-Yan
Publicado 2022

Targeting papain-like protease for broad-spectrum coronavirus inhibition

por Yuan, Shuofeng, Gao, Xiaopan, Tang, Kaiming, Cai, Jian-Piao, Hu, Menglong, Luo, Peng, Wen, Lei, Ye, Zi-Wei, Luo, Cuiting, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Huang, Yaoqiang, Cao, Jianli, Liang, Ronghui, Qin, Zhenzhi, Qin, Bo, Yin, Feifei, Chu, Hin, Jin, Dong-Yan, Sun, Ren, Chan, Jasper Fuk-Woo, Cui, Sheng, Yuen, Kwok-Yung
Publicado 2022

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage

por Liang, Ronghui, Ye, Zi-Wei, Ong, Chon Phin, Qin, Zhenzhi, Xie, Yubin, Fan, Yilan, Tang, Kaiming, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Yang, Xiaomeng, Cao, Hehe, Wang, Kun, Sun, Haoran, Hu, Bodan, Cai, Jian-Piao, Luo, Cuiting, Chik, Kenn Ka-Heng, Chu, Hin, Zheng, Yi, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Jin, Dong-Yan, Yuan, Shuofeng
Publicado 2022

Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro

por Hou, Ningke, Shuai, Lei, Zhang, Lijing, Xie, Xuping, Tang, Kaiming, Zhu, Yunkai, Yu, Yin, Zhang, Wenyi, Tan, Qiaozhu, Zhong, Gongxun, Wen, Zhiyuan, Wang, Chong, He, Xijun, Huo, Hong, Gao, Haishan, Xu, You, Xue, Jing, Peng, Chen, Zou, Jing, Schindewolf, Craig, Menachery, Vineet, Su, Wenji, Yuan, Youlang, Shen, Zuyuan, Zhang, Rong, Yuan, Shuofeng, Yu, Hongtao, Shi, Pei-Yong, Bu, Zhigao, Huang, Jing, Hu, Qi
Publicado 2023