Super-enhancer-associated TTC8 alters the nucleocytoplasmic distribution of PHOX2B and activates MAPK signaling in neuroblastoma

por Zhuo, Ran, Zhang, Zimu, Guo, Xinyi, Cao, Haibo, Chen, Yanling, Tao, Yanfang, Yang, Randong, Li, Xiaolu, Pan, Jian, Wang, Jian
Publicado 2022

The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells

por Li, Zhiheng, Yang, Chun, Li, Xiaolu, Du, Xiaojuan, Tao, Yanfang, Ren, Junli, Fang, Fang, Xie, Yi, Li, Mei, Qian, Guanghui, Xu, Lixiao, Cao, Xu, Wu, Yi, Lv, Haitao, Hu, Shaoyan, Lu, Jun, Pan, Jian
Publicado 2020

ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways

por Liao, Xinmei, Qian, Xiaoqing, Zhang, Zimu, Tao, Yanfang, Li, Zhiheng, Zhang, Qian, Liang, Hui, Li, Xiaolu, Xie, Yi, Zhuo, Ran, Chen, Yanling, Jiang, You, Cao, Haibo, Niu, Jiaqi, Xue, Cuili, Ni, Jian, Pan, Jian, Cui, Daxiang
Publicado 2021

Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4

por Li, Zhiheng, Li, Xiaolu, Xu, Lixiao, Tao, Yanfang, Yang, Chun, Chen, Xiaolan, Fang, Fang, Wu, Yi, Ding, Xin, Zhao, He, Li, Mei, Qian, Guanghui, Xu, Yunyun, Ren, Junli, Du, Weiwei, Wang, Jian, Lu, Jun, Hu, Shaoyan, Pan, Jian
Publicado 2017

Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1

por Zhang, Kunlong, Lu, Jun, Fang, Fang, Zhang, Yongping, Yu, Juanjuan, Tao, Yanfang, liu, Wenyuan, Lu, Lihui, Zhang, Zimu, Chu, Xinran, Wang, Jianwei, Li, Xiaolu, Tian, Yuanyuan, Li, Zhiheng, Li, Qian, Sang, Xu, Ma, Li, Wang, Ningling, Pan, Jian, Hu, Shaoyan
Publicado 2023

BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes

por Wu, Shuiyan, Jiang, You, Hong, Yi, Chu, Xinran, Zhang, Zimu, Tao, Yanfang, Fan, Ziwei, Bai, Zhenjiang, Li, Xiaolu, Chen, Yanling, Li, Zhiheng, Ding, Xin, Lv, Haitao, Du, Xiaoli, Lim, Su Lin, Zhang, Yongping, Huang, Saihu, Lu, Jun, Pan, Jian, Hu, Shaoyan
Publicado 2021

A Novel BRD Family PROTAC Inhibitor dBET1 Exerts Great Anti-Cancer Effects by Targeting c-MYC in Acute Myeloid Leukemia Cells

por Zhang, Kunlong, Gao, Li, Wang, Jianwei, Chu, Xinran, Zhang, Zimu, Zhang, Yongping, Fang, Fang, Tao, Yanfang, Li, Xiaolu, Tian, Yuanyuan, Li, Zhiheng, Sang, Xu, Ma, Li, Lu, Lihui, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Pan, Jian, Hu, Shaoyan
Publicado 2022

BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes

por Ma, Li, Wang, Jianwei, Zhang, Yongping, Fang, Fang, Ling, Jing, Chu, Xinran, Zhang, Zimu, Tao, Yanfang, Li, Xiaolu, Tian, Yuanyuan, Li, Zhiheng, Sang, Xu, Zhang, Kunlong, Lu, Lihui, Wan, Xiaomei, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Lu, Jun, Pan, Jian, Hu, Shaoyan
Publicado 2022

BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia

por Sang, Xu, Zhang, Yongping, Fang, Fang, Gao, Li, Tao, Yanfang, Li, Xiaolu, Zhang, Zimu, Wang, Jianwei, Tian, Yuanyuan, Li, Zhiheng, Yao, Di, Wu, Yumeng, Chu, Xinran, Zhang, Kunlong, Ma, Li, Lu, Lihui, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Zhang, Zhen, Pan, Jian, Hu, Shaoyan
Publicado 2022

PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc

por Li, Zhiheng, Lim, Su Lin, Tao, Yanfang, Li, Xiaolu, Xie, Yi, Yang, Chun, Zhang, Zimu, Jiang, You, Zhang, Xianbing, Cao, Xu, Wang, Hairong, Qian, Guanghui, Wu, Yi, Li, Mei, Fang, Fang, Liu, Ying, Fu, Mingcui, Ding, Xin, Zhu, Zhenghong, Lv, Haitao, Lu, Jun, Xiao, Sheng, Hu, Shaoyan, Pan, Jian
Publicado 2020

Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma

por Cao, Haibo, Zhuo, Ran, Zhang, Zimu, Wang, Jianwei, Tao, Yanfang, Yang, Randong, Guo, Xinyi, Chen, Yanling, Jia, Siqi, Yao, Ye, Yang, Pengcheng, Yu, Juanjuan, Jiao, Wanyan, Li, Xiaolu, Fang, Fang, Xie, Yi, Li, Gen, Wu, Di, Wang, Hairong, Feng, Chenxi, Xu, Yunyun, Li, Zhiheng, Pan, Jian, Wang, Jian
Publicado 2022

LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1

por Lu, Lihui, Wang, Jianwei, Fang, Fang, Guo, Ailian, Jiang, Shuting, Tao, Yanfang, Zhang, Yongping, Li, Yan, Zhang, Kunlong, Zhang, Zimu, Zhuo, Ran, Chu, Xinran, Li, Xiaolu, Tian, Yuanyuan, Ma, Li, Sang, Xu, Chen, Yanling, Yu, Juanjuan, Yang, Yang, Cao, Haibo, Gao, Jizhao, Lu, Jun, Hu, Shaoyan, Pan, Jian, He, Hailong
Publicado 2023