DIPG-80. CLINICAL AND RADIOGRAPHIC RESPONSE TO ONC201 IN A PEDIATRIC PATIENT WITH A THALAMIC H3K27M AND BRAFV600E MUTANT DIFFUSE MIDLINE HIGH GRADE GLIOMA

por Duke, Elizabeth, Murnick, Jonathan, Tarapore, Rohinton, Allen, Joshua, Kilburn, Lindsay
Publicado 2020

ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways

por Ni, Xiao, Zhang, Xiang, Hu, Cheng-Hui, Langridge, Timothy, Tarapore, Rohinton S., Allen, Joshua E., Oster, Wolfgang, Duvic, Madeleine
Publicado 2017

Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B

por Pacios, Sandra, Xiao, Wenmei, Mattos, Marcelo, Lim, Jason, Tarapore, Rohinton S., Alsadun, Sarah, Yu, Bo, Wang, Cun-Yu, Graves, Dana T.
Publicado 2015

FOXO1 differentially regulates both normal and diabetic wound healing

por Zhang, Chenying, Ponugoti, Bhaskar, Tian, Chen, Xu, Fanxing, Tarapore, Rohinton, Batres, Angelika, Alsadun, Sarah, Lim, Jason, Dong, Guangyu, Graves, Dana T.
Publicado 2015

BMI1 Polycomb Group Protein Acts as a Master Switch for Growth and Death of Tumor Cells: Regulates TCF4-Transcriptional Factor-Induced BCL2 Signaling

por Siddique, Hifzur Rahman, Parray, Aijaz, Tarapore, Rohinton S., Wang, Lei, Mukhtar, Hasan, Karnes, R. Jeffery, Deng, Yibin, Konety, Badrinath R., Saleem, Mohammad
Publicado 2013

Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor

por Anderson, Peter M., Trucco, Matteo M., Tarapore, Rohinton S., Zahler, Stacey, Thomas, Stefanie, Gortz, Janette, Mian, Omar, Stoignew, Martin, Prabhu, Varun, Morrow, Sara, Allen, Joshua E.
Publicado 2022

Foxo1 Inhibits Diabetic Mucosal Wound Healing but Enhances Healing of Normoglycemic Wounds

por Xu, Fanxing, Othman, Badr, Lim, Jason, Batres, Angelika, Ponugoti, Bhaskar, Zhang, Chenying, Yi, Leah, Liu, Jian, Tian, Chen, Hameedaldeen, Alhassan, Alsadun, Sarah, Tarapore, Rohinton, Graves, Dana T.
Publicado 2015

DIPG-57. TRANSCRIPTOMIC AND PROTEOMIC ANALYSES OF DIPG RESPONSE TO ONC201

por Sridharan, Sreepradha, Harmanci, Arif, Sharma, Ajay, Lai, Yanlai, Kennis, Bridget, Dobson, Tara, Swaminathan, Jyothishmathi, Haltom, Amanda, Khatua, Soumen, Tarapore, Rohinton, Allen, Joshua, Cheng, Donghang, Zaky, Wafik, Gopalakrishnan, Vidya
Publicado 2020

TIPS-08 ACTION: A RANDOMIZED PHASE 3 STUDY OF DORDAVIPRONE (ONC201) IN PATIENTS WITH NEWLY DIAGNOSED H3 K27M-MUTANT DIFFUSE GLIOMA

por Arrillaga-Romany, Isabel, Lassman, Andrew, McGovern, Susan, Mueller, Sabine, Nabors, Louis Burt, van den Bent, Martin, Vogelbaum, Michael, Allen, Joshua E, Melemed, Allen S, Tarapore, Rohinton, Wen, Patrick, Cloughsey, Timothy
Publicado 2023

Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype

por Hu, Wen, Zhang, Li, Ferri-Borgogno, Sammy, Kwan, Suet-Ying, Lewis, Kelsey E., Cun, Han T., Yeung, Tsz-Lun, Soliman, Pamela T., Tarapore, Rohinton S., Allen, Joshua E., Guan, Xinyuan, Lu, Karen H., Mok, Samuel C., Au-Yeung, Chi-Lam
Publicado 2020

Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

por Amoroso, Francesca, Glass, Kimberley, Singh, Reema, Liberal, Francisco, Steele, Rebecca E., Maguire, Sarah, Tarapore, Rohinton, Allen, Joshua E., Van Schaeybroeck, Sandra, Butterworth, Karl T., Prise, Kevin, O’Sullivan, Joe M., Jain, Suneil, Waugh, David J., Mills, Ian G.
Publicado 2021

Correction: Hu, W., et al. Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype. Cancers 2020, 12, 2436

por Hu, Wen, Zhang, Li, Ferri-Borgogno, Sammy, Kwan, Suet-Ying, Lewis, Kelsey E., Cun, Han T., Yeung, Tsz-Lun, Soliman, Pamela T., Tarapore, Rohinton S., Allen, Joshua E., Guan, Xinyuan, Lu, Karen H., Mok, Samuel C., Au-Yeung, Chi-Lam
Publicado 2021

SYST-07 WINDOW-OF-OPPORTUNITY STUDY OF ONC201 IN PEDIATRIC PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND THALAMIC GLIOMA

por Odia, Yazmin, Koschmann, Carl, Tarapore, Rohinton, Allen, Jeffrey, Hall, Matthew, Daghistani, Doured, Khatib, Ziad, Aguilera, Dolly, MacDonald, Tobey, de Blank, Peter, McGovern, Susan Lynne, Mueller, Sabine, Kline, Cassie, Vitanza, Nicholas, Allen, Joshua E, Zaky, Wafik, Gardner, Sharon
Publicado 2022

DIPG-52. PHASE I CLINICAL TRIAL OF ONC201 IN PEDIATRIC H3 K27M-MUTANT GLIOMA OR NEWLY DIAGNOSED DIPG

por Gardner, Sharon, Tarapore, Rohinton, Allen, Jeffrey, Zaky, Wafik, Odia, Yazmin, Hall, Matthew, Daghistani, Doured, Khatib, Ziad, Koschmann, Carl, Aguilera, Dolly, MacDonald, Tobey, Fouladi, Maryam, McGovern, Susan, Kline, Cassie, Vitanza, Nicholas, Lu, Guangrong, Merdinger, Krystal, Oster, Wolfgang, Allen, Joshua, Khatua, Soumen
Publicado 2020

Phase I dose escalation and expansion trial of single agent ONC201 in pediatric diffuse midline gliomas following radiotherapy

por Gardner, Sharon L, Tarapore, Rohinton S, Allen, Jeffrey, McGovern, Susan L, Zaky, Wafik, Odia, Yazmin, Daghistani, Doured, Diaz, Zuanel, Hall, Matthew D, Khatib, Ziad, Koschmann, Carl, Cantor, Evan, Kurokawa, Ryo, MacDonald, Tobey J, Aguilera, Dolly, Vitanza, Nicholas A, Mueller, Sabine, Kline, Cassie, Lu, Guangrong, Allen, Joshua E, Khatua, Soumen
Publicado 2022

ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

por Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.
Publicado 2020

EPCT-03. SERIAL PLASMA AND CSF CELL-FREE TUMOR DNA (CF-TDNA) TRACKING IN DIFFUSE MIDLINE GLIOMA PATIENTS UNDERGOING TREATMENT WITH ONC201

por Cantor, Evan, Wierzbicki, Kyle, Tarapore, Rohinton S, Thomas, Chase, Cartaxo, Rodrigo, Yadav, Viveka Nand, Ravindran, Ramya, Bruzek, Amy K, Wadden, Jack, Babilla, Clarissa May, Kawakibi, Abed Rhaman, Ji, Sunjong, Ramos, Johanna, Paul, Alyssa, Wolfe, Ian, Leonard, Marcia, Robertson, Partricia, Franson, Andrea, Mody, Rajen, Garton, Hugh, Odia, Yazmin, Kline, Cassie, Vitanza, Nicholas A, Khatua, Soumen, Mueller, Sabine, Allen, Joshua E, Gardner, Sharon, Koschmann, Carl
Publicado 2021

Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma

por Cantor, Evan, Wierzbicki, Kyle, Tarapore, Rohinton S, Ravi, Karthik, Thomas, Chase, Cartaxo, Rodrigo, Nand Yadav, Viveka, Ravindran, Ramya, Bruzek, Amy K, Wadden, Jack, John, Vishal, May Babila, Clarissa, Cummings, Jessica R, Rahman Kawakibi, Abed, Ji, Sunjong, Ramos, Johanna, Paul, Alyssa, Walling, Dustin, Leonard, Marcia, Robertson, Patricia, Franson, Andrea, Mody, Rajen, Garton, Hugh J L, Venneti, Sriram, Odia, Yazmin, Kline, Cassie, Vitanza, Nicholas A, Khatua, Soumen, Mueller, Sabine, Allen, Joshua E, Gardner, Sharon L, Koschmann, Carl
Publicado 2022

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration

por Stein, Mark N., Malhotra, Jyoti, Tarapore, Rohinton S., Malhotra, Usha, Silk, Ann W., Chan, Nancy, Rodriguez, Lorna, Aisner, Joseph, Aiken, Robert D., Mayer, Tina, Haffty, Bruce G., Newman, Jenna H., Aspromonte, Salvatore M., Bommareddy, Praveen K., Estupinian, Ricardo, Chesson, Charles B., Sadimin, Evita T., Li, Shengguo, Medina, Daniel J., Saunders, Tracie, Frankel, Melissa, Kareddula, Aparna, Damare, Sherrie, Wesolowsky, Elayne, Gabel, Christian, El-Deiry, Wafik S., Prabhu, Varun V., Allen, Joshua E., Stogniew, Martin, Oster, Wolfgang, Bertino, Joseph R., Libutti, Steven K., Mehnert, Janice M., Zloza, Andrew
Publicado 2019

HGG-18. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA

por Kawakibi, Abed Rahman, Tarapore, Rohinton S, Gardner, Sharon, Chi, Andrew, Kurz, Sylvia, Wen, Patrick Y, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Butowski, Nicholas A, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, DeGroot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew D, Daghistani, Doured, Cloughesy, Timothy F, Ellingson, Benjamin M, Umemura, Yoshie, Schwartz, Jonathan, Yadav, Vivekanand, Cartaxo, Rodrigo, Siada, Ruby, Miklja, Zachary, Bruzek, Amy, Cantor, Evan, Wierzbicki, Kyle, Paul, Alyssa, Wolfe, Ian, Leaoard, Marcia, Garton, Hugh, Mody, Rajen, Robertson, Patricia L, Lu, Guangrong, Merdinger, Krystal, Venneti, Sriram, Oster, Wolfgang, Allen, Joshua E, Koschmann, Carl
Publicado 2020