Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program

por Valverde Mordt, Olaf, Tarral, Antoine, Strub-Wourgaft, Nathalie
Publicado 2022

Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole

por Watson, James A., Strub-Wourgraft, Nathalie, Tarral, Antoine, Ribeiro, Isabela, Tarning, Joel, White, Nicholas J.
Publicado 2019

Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies

por Tarral, Antoine, Blesson, Séverine, Mordt, Olaf Valverde, Torreele, Els, Sassella, Daniela, Bray, Michael A., Hovsepian, Lionel, Evène, Eric, Gualano, Virginie, Felices, Mathieu, Strub-Wourgaft, Nathalie
Publicado 2014

Determination of the Optimal Single Dose Treatment for Acoziborole, a Novel Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Study

por Tarral, Antoine, Hovsepian, Lionel, Duvauchelle, Thierry, Donazzolo, Yves, Latreille, Mathilde, Felices, Mathieu, Gualano, Virginie, Delhomme, Sophie, Valverde Mordt, Olaf, Blesson, Severine, Voiriot, Pascal, Strub-Wourgaft, Nathalie
Publicado 2023

Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

por Alvar, Jorge, Alves, Fabiana, Bucheton, Bruno, Burrows, Louise, Büscher, Philippe, Carrillo, Eugenia, Felger, Ingrid, Hübner, Marc P., Moreno, Javier, Pinazo, Maria-Jesus, Ribeiro, Isabela, Sosa-Estani, Sergio, Specht, Sabine, Tarral, Antoine, Wourgaft, Nathalie Strub, Bilbe, Graeme
Publicado 2020

Trypanosome SL-RNA detection in blood and cerebrospinal fluid to demonstrate active gambiense human African trypanosomiasis infection

por Ngay Lukusa, Ipos, Van Reet, Nick, Mumba Ngoyi, Dieudonné, Miaka, Erick Mwamba, Masumu, Justin, Patient Pyana, Pati, Mutombo, Wilfried, Ngolo, Digas, Kobo, Vincent, Akwaso, Felix, Ilunga, Médard, Kaninda, Lewis, Mutanda, Sylvain, Muamba, Dieudonné Mpoyi, Valverde Mordt, Olaf, Tarral, Antoine, Rembry, Sandra, Büscher, Philippe, Lejon, Veerle
Publicado 2021

Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: A longitudinal follow-up study

por Ngay Lukusa, Ipos, Van Reet, Nick, Mumba Ngoyi, Dieudonné, Mwamba Miaka, Erick, Masumu, Justin, Patient Pyana, Pati, Mutombo, Wilfried, Ngolo, Digas, Kobo, Vincent, Akwaso, Felix, Ilunga, Médard, Kaninda, Lewis, Mutanda, Sylvain, Mpoyi Muamba, Dieudonné, Valverde Mordt, Olaf, Tarral, Antoine, Rembry, Sandra, Büscher, Philippe, Lejon, Veerle
Publicado 2022

Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2–3 trial

por Kande Betu Kumesu, Victor, Mutombo Kalonji, Wilfried, Bardonneau, Clélia, Valverde Mordt, Olaf, Ngolo Tete, Digas, Blesson, Séverine, Simon, François, Delhomme, Sophie, Bernhard, Sonja, Nganzobo Ngima, Pathou, Mahenzi Mbembo, Hélène, Fina Lubaki, Jean-Pierre, Lumeya Vuvu, Steven, Kuziena Mindele, Willy, Ilunga Wa Kyhi, Médard, Mandula Mokenge, Guylain, Kaninda Badibabi, Lewis, Kasongo Bonama, Augustin, Kavunga Lukula, Papy, Lumbala, Crispin, Scherrer, Bruno, Strub-Wourgaft, Nathalie, Tarral, Antoine
Publicado 2022

Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study

por Kande Betu Ku Mesu, Victor, Mutombo Kalonji, Wilfried, Bardonneau, Clélia, Valverde Mordt, Olaf, Ngolo Tete, Digas, Blesson, Séverine, Simon, François, Delhomme, Sophie, Bernhard, Sonja, Mahenzi Mbembo, Hélène, Mpia Moke, Christian, Lumeya Vuvu, Steven, Mudji E'kitiak, Junior, Akwaso Masa, Felix, Mukendi Ilunga, Melchias, Mpoyi Muamba Nzambi, Dieudonné, Mayala Malu, Tim, Kapongo Tshilumbwa, Serge, Botalema Bolengi, Franck, Nkieri Matsho, Mathieu, Lumbala, Crispin, Scherrer, Bruno, Strub-Wourgaft, Nathalie, Tarral, Antoine
Publicado 2021

Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial

por Betu Kumeso, Victor Kande, Kalonji, Wilfried Mutombo, Rembry, Sandra, Valverde Mordt, Olaf, Ngolo Tete, Digas, Prêtre, Adeline, Delhomme, Sophie, Ilunga Wa Kyhi, Médard, Camara, Mamadou, Catusse, Julie, Schneitter, Stefan, Nusbaumer, Morgane, Mwamba Miaka, Erick, Mahenzi Mbembo, Hélène, Makaya Mayawula, Joseph, Layba Camara, Mariame, Akwaso Massa, Félix, Kaninda Badibabi, Lewis, Kasongo Bonama, Augustin, Kavunga Lukula, Papy, Mutanda Kalonji, Sylvain, Mariero Philemon, Phyll, Mokilifi Nganyonyi, Ricardo, Embana Mankiara, Hugues, Asuka Akongo Nguba, André, Kobo Muanza, Vincent, Mulenge Nasandhel, Ernest, Fifi Nzeza Bambuwu, Aimée, Scherrer, Bruno, Strub-Wourgaft, Nathalie, Tarral, Antoine
Publicado 2023