The Missing Link between (Un)druggable and Degradable KRAS

por De Vita, Elena, Maneiro, Maria, Tate, Edward W.
Publicado 2020

UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology

por Mondal, Milon, Conole, Daniel, Nautiyal, Jaya, Tate, Edward W.
Publicado 2021

Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes

por Conole, Daniel, Mondal, Milon, Majmudar, Jaimeen D., Tate, Edward W.
Publicado 2019

Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex

por Saunders, Charlie N., Cota, Ernesto, Baum, Jake, Tate, Edward W.
Publicado 2020

Dynamics and Molecular Interactions of GPI-Anchored CD59

por Voisin, Tomas B., Couves, Emma C., Tate, Edward W., Bubeck, Doryen
Publicado 2023

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells

por Thinon, Emmanuelle, Morales-Sanfrutos, Julia, Mann, David J., Tate, Edward W.
Publicado 2016

XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus

por Ledger, Elizabeth V. K., Lau, Katie, Tate, Edward W., Edwards, Andrew M.
Publicado 2023

Targeting a Dynamic Protein–Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex

por Douse, Christopher H, Vrielink, Nina, Wenlin, Zhang, Cota, Ernesto, Tate, Edward W
Publicado 2015

High-yielding (18)F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

por Beard, Rhiannon, Singh, Nisha, Grundschober, Christophe, Gee, Antony D., Tate, Edward W.
Publicado 2018

Chemical biology tools for probing transcytosis at the blood–brain barrier

por Beard, Rhiannon, Gaboriau, David C. A., Gee, Antony D., Tate, Edward W.
Publicado 2019

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics

por Serwa, Remigiusz A., Abaitua, Fernando, Krause, Eberhard, Tate, Edward W., O’Hare, Peter
Publicado 2015

Global profiling of protein lipidation using chemical proteomic technologies

por Tate, Edward W, Kalesh, Karunakaran A, Lanyon-Hogg, Thomas, Storck, Elisabeth M, Thinon, Emmanuelle
Publicado 2015

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei

por Wright, Megan H., Paape, Daniel, Price, Helen P., Smith, Deborah F., Tate, Edward W.
Publicado 2016

Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A

por Goya Grocin, Andrea, Serwa, Remigiusz A., Morales Sanfrutos, Julia, Ritzefeld, Markus, Tate, Edward W.
Publicado 2019

Crystal Structure of the Human, FIC-Domain Containing Protein HYPE and Implications for Its Functions

por Bunney, Tom D., Cole, Ambrose R., Broncel, Malgorzata, Esposito, Diego, Tate, Edward W., Katan, Matilda
Publicado 2014

Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a

por Jamshidiha, Mostafa, Pérez-Dorado, Inmaculada, Murray, James W., Tate, Edward W., Cota, Ernesto, Read, Randy J.
Publicado 2019

Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gα(i/o) Pathway

por Shackley, Matilda, Ma, Yue, Tate, Edward W., Brown, Alastair J. H., Frost, Gary, Hanyaloglu, Aylin C.
Publicado 2020

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism

por Fedoryshchak, Roman O., Ocasio, Cory A., Strutton, Benjamin, Mattocks, Jo, Corran, Andrew J., Tate, Edward W.
Publicado 2020

Discovery of lipid-mediated protein–protein interactions in living cells using metabolic labeling with photoactivatable clickable probes

por Fedoryshchak, Roman O., Gorelik, Andrii, Shen, Mengjie, Shchepinova, Maria M., Pérez-Dorado, Inmaculada, Tate, Edward W.
Publicado 2023

Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani

por Wright, Megan H., Paape, Daniel, Storck, Elisabeth M., Serwa, Remigiusz A., Smith, Deborah F., Tate, Edward W.
Publicado 2015