Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds

por Tatum, Natalie J., Duarte, Fernanda, Kamerlin, Shina C. L., Pohl, Ehmke
Publicado 2019

An open-source molecular builder and free energy preparation workflow

por Bieniek, Mateusz K., Cree, Ben, Pirie, Rachael, Horton, Joshua T., Tatum, Natalie J., Cole, Daniel J.
Publicado 2022

Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids

por Haffez, Hesham, Chisholm, David R., Tatum, Natalie J., Valentine, Roy, Redfern, Christopher, Pohl, Ehmke, Whiting, Andrew, Przyborski, Stefan
Publicado 2018

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

por Wood, Daniel J., Korolchuk, Svitlana, Tatum, Natalie J., Wang, Lan-Zhen, Endicott, Jane A., Noble, Martin E.M., Martin, Mathew P.
Publicado 2019

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

por Lochhead, Pamela A., Tucker, Julie A., Tatum, Natalie J., Wang, Jinhua, Oxley, David, Kidger, Andrew M., Johnson, Victoria P., Cassidy, Megan A., Gray, Nathanael S., Noble, Martin E. M., Cook, Simon J.
Publicado 2020

FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers

por Mesquita, Katia A., Ali, Reem, Doherty, Rachel, Toss, Michael S., Miligy, Islam, Alblihy, Adel, Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M., Hickson, Ian, Tatum, Natalie J., Rakha, Emad A., Madhusudan, Srinivasan
Publicado 2021

Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers

por Alblihy, Adel, Ali, Reem, Algethami, Mashael, Shoqafi, Ahmed, Toss, Michael S., Brownlie, Juliette, Tatum, Natalie J., Hickson, Ian, Moran, Paloma Ordonez, Grabowska, Anna, Jeyapalan, Jennie N., Mongan, Nigel P., Rakha, Emad A., Madhusudan, Srinivasan
Publicado 2022

Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation

por Salamina, Marco, Montefiore, Bailey C., Liu, Mengxi, Wood, Daniel J., Heath, Richard, Ault, James R., Wang, Lan-Zhen, Korolchuk, Svitlana, Baslé, Arnaud, Pastok, Martyna W., Reeks, Judith, Tatum, Natalie J., Sobott, Frank, Arold, Stefan T., Pagano, Michele, Noble, Martin E.M., Endicott, Jane A.
Publicado 2021