Biological Functions of the Intrinsically Disordered N-Terminal Domain of the Prion Protein: A Possible Role of Liquid–Liquid Phase Separation

por Polido, Stella A., Kamps, Janine, Tatzelt, Jörg
Publicado 2021

SecY-mediated quality control prevents the translocation of non-gated porins

por Jung, Sebastian, Bader, Verian, Natriashvili, Ana, Koch, Hans-Georg, Winklhofer, Konstanze F., Tatzelt, Jörg
Publicado 2020

The Cellular Prion Protein: A Player in Immunological Quiescence

por Bakkebø, Maren K., Mouillet-Richard, Sophie, Espenes, Arild, Goldmann, Wilfred, Tatzelt, Jörg, Tranulis, Michael A.
Publicado 2015

The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

por Sangeetham, Sudheer Babu, Engelke, Anna Dorothee, Fodor, Elfrieda, Krausz, Sarah Laura, Tatzelt, Jörg, Welker, Ervin
Publicado 2021

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

por Ziska, Anke, Tatzelt, Jörg, Dudek, Johanna, Paton, Adrienne W., Paton, James C., Zimmermann, Richard, Haßdenteufel, Sarah
Publicado 2019

The N-terminal domain of the prion protein is required and sufficient for liquid–liquid phase separation: A crucial role of the Aβ-binding domain

por Kamps, Janine, Lin, Yu-Hsuan, Oliva, Rosario, Bader, Verian, Winter, Roland, Winklhofer, Konstanze F., Tatzelt, Jörg
Publicado 2021

Parkin Is Protective against Proteotoxic Stress in a Transgenic Zebrafish Model

por Fett, Mareike E., Pilsl, Anna, Paquet, Dominik, van Bebber, Frauke, Haass, Christian, Tatzelt, Jörg, Schmid, Bettina, Winklhofer, Konstanze F.
Publicado 2010

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)

por McCarthy, James M., Franke, Markus, Resenberger, Ulrike K., Waldron, Sibeal, Simpson, Jeremy C., Tatzelt, Jörg, Appelhans, Dietmar, Rogers, Mark S.
Publicado 2013

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrP(C)) in Alzheimer’s disease

por Ulbrich, Sarah, Janning, Petra, Seidel, Ralf, Matschke, Jakob, Gonsberg, Anika, Jung, Sebastian, Glatzel, Markus, Engelhard, Martin, Winklhofer, Konstanze F., Tatzelt, Jörg
Publicado 2018

GPI-anchor signal sequence influences PrP(C) sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

por Puig, Berta, Altmeppen, Hermann C., Linsenmeier, Luise, Chakroun, Karima, Wegwitz, Florian, Piontek, Ulrike K., Tatzelt, Jörg, Bate, Clive, Magnus, Tim, Glatzel, Markus
Publicado 2019

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

por Puig, Berta, Altmeppen, Hermann C., Ulbrich, Sarah, Linsenmeier, Luise, Krasemann, Susanne, Chakroun, Karima, Acevedo-Morantes, Claudia Y., Wille, Holger, Tatzelt, Jörg, Glatzel, Markus
Publicado 2016

Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities

por Atarod, Deyhim, Mamashli, Fatemeh, Ghasemi, Atiyeh, Moosavi-Movahedi, Faezeh, Pirhaghi, Mitra, Nedaei, Hadi, Muronetz, Vladimir, Haertlé, Thomas, Tatzelt, Jörg, Riazi, Gholamhossein, Saboury, Ali Akbar
Publicado 2022

Remodeling of the Fibrillation Pathway of α‐Synuclein by Interaction with Antimicrobial Peptide LL‐III

por Oliva, Rosario, Mukherjee, Sanjib K., Ostermeier, Lena, Pazurek, Lilli A., Kriegler, Simon, Bader, Verian, Prumbaum, Daniel, Raunser, Stefan, Winklhofer, Konstanze F., Tatzelt, Jörg, Winter, Roland
Publicado 2021

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

por Wu, Bei, McDonald, Alex J, Markham, Kathleen, Rich, Celeste B, McHugh, Kyle P, Tatzelt, Jörg, Colby, David W, Millhauser, Glenn L, Harris, David A
Publicado 2017

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

por Linsenmeier, Luise, Mohammadi, Behnam, Wetzel, Sebastian, Puig, Berta, Jackson, Walker S., Hartmann, Alexander, Uchiyama, Keiji, Sakaguchi, Suehiro, Endres, Kristina, Tatzelt, Jörg, Saftig, Paul, Glatzel, Markus, Altmeppen, Hermann C.
Publicado 2018

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

por Mohammadi, Behnam, Linsenmeier, Luise, Shafiq, Mohsin, Puig, Berta, Galliciotti, Giovanna, Giudici, Camilla, Willem, Michael, Eden, Thomas, Koch-Nolte, Friedrich, Lin, Yu-Hsuan, Tatzelt, Jörg, Glatzel, Markus, Altmeppen, Hermann C.
Publicado 2020

Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling

por Goel, Simran, Oliva, Rosario, Jeganathan, Sadasivam, Bader, Verian, Krause, Laura J, Kriegler, Simon, Stender, Isabelle D, Christine, Chadwick W, Nakamura, Ken, Hoffmann, Jan-Erik, Winter, Roland, Tatzelt, Jörg, Winklhofer, Konstanze F
Publicado 2023

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice

por Eigenbrod, Sabina, Frick, Petra, Bertsch, Uwe, Mitteregger-Kretzschmar, Gerda, Mielke, Janina, Maringer, Marko, Piening, Niklas, Hepp, Alexander, Daude, Nathalie, Windl, Otto, Levin, Johannes, Giese, Armin, Sakthivelu, Vignesh, Tatzelt, Jörg, Kretzschmar, Hans, Westaway, David
Publicado 2017

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus

por Wu, Zhixiao, Berlemann, Lena A, Bader, Verian, Sehr, Dominik A, Dawin, Eva, Covallero, Alberto, Meschede, Jens, Angersbach, Lena, Showkat, Cathrin, Michaelis, Jonas B, Münch, Christian, Rieger, Bettina, Namgaladze, Dmitry, Herrera, Maria Georgina, Fiesel, Fabienne C, Springer, Wolfdieter, Mendes, Marta, Stepien, Jennifer, Barkovits, Katalin, Marcus, Katrin, Sickmann, Albert, Dittmar, Gunnar, Busch, Karin B, Riedel, Dietmar, Brini, Marisa, Tatzelt, Jörg, Cali, Tito, Winklhofer, Konstanze F
Publicado 2022

Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies

por Linsenmeier, Luise, Mohammadi, Behnam, Shafiq, Mohsin, Frontzek, Karl, Bär, Julia, Shrivastava, Amulya N., Damme, Markus, Song, Feizhi, Schwarz, Alexander, Da Vela, Stefano, Massignan, Tania, Jung, Sebastian, Correia, Angela, Schmitz, Matthias, Puig, Berta, Hornemann, Simone, Zerr, Inga, Tatzelt, Jörg, Biasini, Emiliano, Saftig, Paul, Schweizer, Michaela, Svergun, Dmitri, Amin, Ladan, Mazzola, Federica, Varani, Luca, Thapa, Simrika, Gilch, Sabine, Schätzl, Hermann, Harris, David A., Triller, Antoine, Mikhaylova, Marina, Aguzzi, Adriano, Altmeppen, Hermann C., Glatzel, Markus
Publicado 2021