DNA templates with blocked long 3ʹ end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci

por Bandyopadhyay, Saptaparni, Douglass, Joseph, Kapell, Sebastian, Khan, Nazimuddin, Feitosa-Suntheimer, Fabiana, Klein, Jenny A, Temple, Jasmine, Brown-Culbertson, Jayce, Tavares, Alexander H, Saeed, Mohsan, Lau, Nelson C
Publicado 2021

Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo

por Torchia, James A., Tavares, Alexander H., Carstensen, Laura S., Chen, Da-Yuan, Huang, Jessie, Xiao, Tianshu, Mukherjee, Sonia, Reeves, Patrick M., Tu, Hua, Sluder, Ann E., Chen, Bing, Kotton, Darrell N., Bowen, Richard A., Saeed, Mohsan, Poznansky, Mark C., Freeman, Gordon J.
Publicado 2022

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

por Sanders, David W, Jumper, Chanelle C, Ackerman, Paul J, Bracha, Dan, Donlic, Anita, Kim, Hahn, Kenney, Devin, Castello-Serrano, Ivan, Suzuki, Saori, Tamura, Tomokazu, Tavares, Alexander H, Saeed, Mohsan, Holehouse, Alex S, Ploss, Alexander, Levental, Ilya, Douam, Florian, Padera, Robert F, Levy, Bruce D, Brangwynne, Clifford P
Publicado 2021

Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus

por Chen, Da-Yuan, Turcinovic, Jacquelyn, Feng, Shuchen, Kenney, Devin J., Chin, Chue Vin, Choudhary, Manish C., Conway, Hasahn L., Semaan, Marc, Close, Brianna J., Tavares, Alexander H., Seitz, Scott, Khan, Nazimuddin, Kapell, Sebastian, Crossland, Nicholas A., Li, Jonathan Z., Douam, Florian, Baker, Susan C., Connor, John H., Saeed, Mohsan
Publicado 2023

SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway

por Chen, Da-Yuan, Khan, Nazimuddin, Close, Brianna J., Goel, Raghuveera K., Blum, Benjamin, Tavares, Alexander H., Kenney, Devin, Conway, Hasahn L., Ewoldt, Jourdan K., Chitalia, Vipul C., Crossland, Nicholas A., Chen, Christopher S., Kotton, Darrell N., Baker, Susan C., Fuchs, Serge Y., Connor, John H., Douam, Florian, Emili, Andrew, Saeed, Mohsan
Publicado 2021