Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly

por Shorter, James, Taylor, J. Paul
Publicado 2013

The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD

por Freibaum, Brian D., Taylor, J. Paul
Publicado 2017

Linking hnRNP Function to ALS and FTD Pathology

por Purice, Maria D., Taylor, J. Paul
Publicado 2018

Pathological phase transitions in ALS-FTD impair dynamic RNA–protein granules

por Nedelsky, Natalia B., Taylor, J. Paul
Publicado 2022

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

por McCray, Brett A., Skordalakes, Emmanuel, Taylor, J. Paul
Publicado 2010

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

por Freibaum, Brian D., Messing, James, Yang, Peiguo, Kim, Hong Joo, Taylor, J. Paul
Publicado 2021

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

por Lee, Joo-Yong, Nagano, Yoshito, Taylor, J. Paul, Lim, Kah Leong, Yao, Tso-Pang
Publicado 2010

Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models

por Ahmed, Mhoriam, Spicer, Charlotte, Harley, Jasmine, Taylor, J. Paul, Hanna, Michael, Patani, Rickie, Greensmith, Linda
Publicado 2023

Huntingtin Fragments and SOD1 Mutants Form Soluble Oligomers in the Cell

por Park, Yang-Nim, Zhao, Xiaohong, Norton, Mark, Taylor, J. Paul, Eisenberg, Evan, Greene, Lois E.
Publicado 2012

Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives

por Li, Aixiao, Bouhss, Ahmed, Clément, Marie-Jeanne, Bauvais, Cyril, Taylor, J. Paul, Bollot, Guillaume, Pastré, David
Publicado 2023

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

por Zhang, Peipei, Fan, Baochang, Yang, Peiguo, Temirov, Jamshid, Messing, James, Kim, Hong Joo, Taylor, J Paul
Publicado 2019

Network Analyses Reveal Novel Aspects of ALS Pathogenesis

por Sanhueza, Mario, Chai, Andrea, Smith, Colin, McCray, Brett A., Simpson, T. Ian, Taylor, J. Paul, Pennetta, Giuseppa
Publicado 2015

A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B Is Expressed Exclusively in Mature Striated Muscle Cells

por Mammen, Andrew L., Mahoney, James A., St. Germain, Amanda, Badders, Nisha, Taylor, J. Paul, Rosen, Antony, Spinette, Sarah
Publicado 2011

hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation

por Batlle, Cristina, Yang, Peiguo, Coughlin, Maura, Messing, James, Pesarrodona, Mireia, Szulc, Elzbieta, Salvatella, Xavier, Kim, Hong Joo, Taylor, J. Paul, Ventura, Salvador
Publicado 2020

Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome

por Todd, Peter K., Oh, Seok Yoon, Krans, Amy, Pandey, Udai B., Di Prospero, Nicholas A., Min, Kyung-Tai, Taylor, J. Paul, Paulson, Henry L.
Publicado 2010

TDP-43 and PINK1 mediate CHCHD10(S59L) mutation–induced defects in Drosophila and in vitro

por Baek, Minwoo, Choe, Yun-Jeong, Bannwarth, Sylvie, Kim, JiHye, Maitra, Swati, Dorn, Gerald W., Taylor, J. Paul, Paquis-Flucklinger, Veronique, Kim, Nam Chul
Publicado 2021

Author Correction: TDP-43 and PINK1 mediate CHCHD10(S59L) mutation–induced defects in Drosophila and in vitro

por Baek, Minwoo, Choe, Yun-Jeong, Bannwarth, Sylvie, Kim, JiHye, Maitra, Swati, Dorn, Gerald W., Taylor, J. Paul, Paquis-Flucklinger, Veronique, Kim, Nam Chul
Publicado 2021

MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex

por Branch, Mary Rose, Hsu, Cynthia L, Ohnishi, Kohta, Shen, Wen-Chuan, Lee, Elian, Meisenhelder, Jill, Winborn, Brett, Sopher, Bryce L, Taylor, J Paul, Hunter, Tony, La Spada, Albert R
Publicado 2023

Analysis of Structural Variants Previously Associated With ALS in Europeans Highlights Genomic Architectural Differences in Africans

por Monnakgotla, Nomakhosazana R., Mahungu, Amokelani C., Heckmann, Jeannine M., Botha, Gerrit, Mulder, Nicola J., Wu, Gang, Rampersaud, Evadnie, Myers, Jason, Van Blitterswijk, Marka, Rademakers, Rosa, Taylor, J. Paul, Wuu, Joanne, Benatar, Michael, Nel, Melissa
Publicado 2023

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

por Valentin-Vega, Yasmine A., Wang, Yong-Dong, Parker, Matthew, Patmore, Deanna M., Kanagaraj, Anderson, Moore, Jennifer, Rusch, Michael, Finkelstein, David, Ellison, David W., Gilbertson, Richard J., Zhang, Jinghui, Kim, Hong Joo, Taylor, J. Paul
Publicado 2016