Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience

por Taymans, Jean-Marc
Publicado 2021

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism

por Taymans, Jean-Marc, Baekelandt, Veerle
Publicado 2014

LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson’s Disease, Where Do We Stand?

por Taymans, Jean-Marc, Greggio, Elisa
Publicado 2016

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases

por Taymans, Jean-Marc, Baekelandt, Veerle, Harvey, Kirsten
Publicado 2014

Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells

por Goveas, Liesel, Mutez, Eugénie, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc
Publicado 2021

Alpha-Synuclein and Lipids: The Elephant in the Room?

por Sarchione, Alessia, Marchand, Antoine, Taymans, Jean-Marc, Chartier-Harlin, Marie-Christine
Publicado 2021

LRRK2 Phosphorylation, More Than an Epiphenomenon

por Marchand, Antoine, Drouyer, Matthieu, Sarchione, Alessia, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc
Publicado 2020

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity

por Lobbestael, Evy, Van den Haute, Chris, Macchi, Francesca, Taymans, Jean-Marc, Baekelandt, Veerle
Publicado 2020

In Vitro Phosphorylation Does not Influence the Aggregation Kinetics of WT α-Synuclein in Contrast to Its Phosphorylation Mutants

por Schreurs, Sarah, Gerard, Melanie, Derua, Rita, Waelkens, Etienne, Taymans, Jean-Marc, Baekelandt, Veerle, Engelborghs, Yves
Publicado 2014

Automated quantitative gait analysis in animal models of movement disorders

por Vandeputte, Caroline, Taymans, Jean-Marc, Casteels, Cindy, Coun, Frea, Ni , Yicheng, Van Laere, Koen, Baekelandt, Veerle
Publicado 2010

The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation

por Kumar, Azad, Greggio, Elisa, Beilina, Alexandra, Kaganovich, Alice, Chan, Diane, Taymans, Jean-Marc, Wolozin, Benjamin, Cookson, Mark R.
Publicado 2010

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

por Taymans, Jean-Marc, Vancraenenbroeck, Renée, Ollikainen, Petri, Beilina, Alexandra, Lobbestael, Evy, De Maeyer, Marc, Baekelandt, Veerle, Cookson, Mark R.
Publicado 2011

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2

por Vancraenenbroeck, Renée, De Raeymaecker, Joren, Lobbestael, Evy, Gao, Fangye, De Maeyer, Marc, Voet, Arnout, Baekelandt, Veerle, Taymans, Jean-Marc
Publicado 2014

Perspective on the current state of the LRRK2 field

por Taymans, Jean-Marc, Fell, Matt, Greenamyre, Tim, Hirst, Warren D., Mamais, Adamantios, Padmanabhan, Shalini, Peter, Inga, Rideout, Hardy, Thaler, Avner
Publicado 2023

Immunohistochemical detection of transgene expression in the brain using small epitope tags

por Lobbestael, Evy, Reumers, Veerle, Ibrahimi, Abdelilah, Paesen, Kirsten, Thiry, Irina, Gijsbers, Rik, Van den Haute, Chris, Debyser, Zeger, Baekelandt, Veerle, Taymans, Jean-Marc
Publicado 2010

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

por Rideout, Hardy J., Chartier-Harlin, Marie-Christine, Fell, Matthew J., Hirst, Warren D., Huntwork-Rodriguez, Sarah, Leyns, Cheryl E. G., Mabrouk, Omar S., Taymans, Jean-Marc
Publicado 2020

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

por Sejwal, Kushal, Chami, Mohamed, Rémigy, Hervé, Vancraenenbroeck, Renée, Sibran, William, Sütterlin, Rosmarie, Baumgartner, Paul, McLeod, Robert, Chartier-Harlin, Marie-Christine, Baekelandt, Veerle, Stahlberg, Henning, Taymans, Jean-Marc
Publicado 2017

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2

por Blanca Ramírez, Marian, Ordóñez, Antonio Jesús Lara, Fdez, Elena, Madero-Pérez, Jesús, Gonnelli, Adriano, Drouyer, Matthieu, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc, Bubacco, Luigi, Greggio, Elisa, Hilfiker, Sabine
Publicado 2017

Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers

por Civiero, Laura, Vancraenenbroeck, Renée, Belluzzi, Elisa, Beilina, Alexandra, Lobbestael, Evy, Reyniers, Lauran, Gao, Fangye, Micetic, Ivan, De Maeyer, Marc, Bubacco, Luigi, Baekelandt, Veerle, Cookson, Mark R., Greggio, Elisa, Taymans, Jean-Marc
Publicado 2012

Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

por Fernández, Belén, Lara Ordóñez, Antonio Jesús, Fdez, Elena, Mutez, Eugénie, Comptdaer, Thomas, Leghay, Coline, Kreisler, Alexandre, Simonin, Clémence, Vandewynckel, Laurine, Defebvre, Luc, Destée, Alain, Bleuse, Séverine, Taymans, Jean-Marc, Chartier-Harlin, Marie-Christine, Hilfiker, Sabine
Publicado 2019