ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

por Timms, Richard T., Tchasovnikarova, Iva A., Antrobus, Robin, Dougan, Gordon, Lehner, Paul J.
Publicado 2016

Defining E3 ligase–substrate relationships through multiplex CRISPR screening

por Timms, Richard T., Mena, Elijah L., Leng, Yumei, Li, Mamie Z., Tchasovnikarova, Iva A., Koren, Itay, Elledge, Stephen J.
Publicado 2023

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

por Douse, Christopher H., Bloor, Stuart, Liu, Yangci, Shamin, Maria, Tchasovnikarova, Iva A., Timms, Richard T., Lehner, Paul J., Modis, Yorgo
Publicado 2018

Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases

por Timms, Richard T., Duncan, Lidia M., Tchasovnikarova, Iva A., Antrobus, Robin, Smith, Duncan L., Dougan, Gordon, Weekes, Michael P., Lehner, Paul J.
Publicado 2013

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

por Timms, Richard T., Menzies, Sam A., Tchasovnikarova, Iva A., Christensen, Lea C., Williamson, James C., Antrobus, Robin, Dougan, Gordon, Ellgaard, Lars, Lehner, Paul J.
Publicado 2016

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

por Robbez-Masson, Luisa, Tie, Christopher H.C., Conde, Lucia, Tunbak, Hale, Husovsky, Connor, Tchasovnikarova, Iva A., Timms, Richard T., Herrero, Javier, Lehner, Paul J., Rowe, Helen M.
Publicado 2018

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

por Douse, Christopher H., Tchasovnikarova, Iva A., Timms, Richard T., Protasio, Anna V., Seczynska, Marta, Prigozhin, Daniil M., Albecka, Anna, Wagstaff, Jane, Williamson, James C., Freund, Stefan M. V., Lehner, Paul J., Modis, Yorgo
Publicado 2020

Periphilin self-association underpins epigenetic silencing by the HUSH complex

por Prigozhin, Daniil M, Douse, Christopher H, Farleigh, Laura E, Albecka, Anna, Tchasovnikarova, Iva A, Timms, Richard T, Oda, Shun-ichiro, Adolf, Frank, Freund, Stefan M V, Maslen, Sarah, Lehner, Paul J, Modis, Yorgo
Publicado 2020