Senolytic drugs: from discovery to translation

por Kirkland, J. L., Tchkonia, T.
Publicado 2020

Cellular Senescence: A Translational Perspective

por Kirkland, James L., Tchkonia, Tamara
Publicado 2017

Growth hormone in adipose dysfunction and senescence

por Stout, Michael B., Tchkonia, Tamara, Kirkland, James L.
Publicado 2015

Senolytics: Potential for Alleviating Diabetes and Its Complications

por Palmer, Allyson K, Tchkonia, Tamar, Kirkland, James L
Publicado 2021

Targeting cellular senescence in metabolic disease

por Palmer, Allyson K., Tchkonia, Tamar, Kirkland, James L.
Publicado 2022

Cell senescence, the senescence-associated secretory phenotype, and cancers

por Langhi Prata, Larissa G. P., Tchkonia, Tamar, Kirkland, James L.
Publicado 2023

Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance

por Blachnio-Zabielska, Agnieszka U., Koutsari, Christina, Tchkonia, Tamara, Jensen, Michael D.
Publicado 2012

Discovery, development, and future application of senolytics: theories and predictions

por Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamar, Kirkland, James L.
Publicado 2020

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

por Song, Shuling, Tchkonia, Tamara, Jiang, Jing, Kirkland, James L., Sun, Yu
Publicado 2020

Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate

por Ishaq, Abbas, Tchkonia, Tamara, Kirkland, James L., Siervo, Mario, Saretzki, Gabriele
Publicado 2022

Inflammatory Characteristics of Adipose Tissue Collected by Surgical Excision vs. Needle Aspiration

por Santosa, Sylvia, Swain, James, Tchkonia, Tamara, Kirkland, James L, Jensen, Michael D
Publicado 2014

IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes

por Neacsu, Otilia, Cleveland, Kelly, Xu, Haiyan, Tchkonia, Tamara T., Kirkland, James L, Boney, Charlotte M
Publicado 2013

Effect of Combined Dasatinib and Fisetin Treatment on Senescent Cell Clearance in Monkeys

por Colman, Ricki, Tchkonia, Tamara, Pirtskhalava, Tamar, Giorgadze, Nino, Prata, Larissa, Schaefer, Kalli, Kirkland, James
Publicado 2020

TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1

por Kandhaya‐Pillai, Renuka, Yang, Xiaomeng, Tchkonia, Tamar, Martin, George M., Kirkland, James L., Oshima, Junko
Publicado 2022

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

por Kandhaya-Pillai, Renuka, Miro-Mur, Francesc, Alijotas-Reig, Jaume, Tchkonia, Tamara, Kirkland, James L., Schwartz, Simo
Publicado 2017

COVID-19 and cellular senescence

por Schmitt, Clemens A., Tchkonia, Tamar, Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L., Lee, Soyoung
Publicado 2022

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype

por Escande, Carlos, Nin, Veronica, Pirtskhalava, Tamar, Chini, Claudia C.S., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N.
Publicado 2015

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

por Palmer, Allyson K., Tchkonia, Tamara, LeBrasseur, Nathan K., Chini, Eduardo N., Xu, Ming, Kirkland, James L.
Publicado 2015

Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex

por Kandhaya-Pillai, Renuka, Miro-Mur, Francesc, Alijotas-Reig, Jaume, Tchkonia, Tamar, Schwartz, Simo, Kirkland, James L., Oshima, Junko
Publicado 2023

Aging, Depot Origin, and Preadipocyte Gene Expression

por Cartwright, Mark J., Schlauch, Karen, Lenburg, Marc E., Tchkonia, Tamara, Pirtskhalava, Tamar, Cartwright, Andrew, Thomou, Thomas, Kirkland, James L.
Publicado 2010