Coordinately Regulated Alternative Splicing of Genes Involved in Cholesterol Biosynthesis and Uptake

por Medina, Marisa Wong, Gao, Feng, Naidoo, Devesh, Rudel, Lawrence L., Temel, Ryan E., McDaniel, Allison L., Marshall, Stephanie M., Krauss, Ronald M.
Publicado 2011

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

por Zhang, Li, Rajbhandari, Prashant, Priest, Christina, Sandhu, Jaspreet, Wu, Xiaohui, Temel, Ryan, Castrillo, Antonio, de Aguiar Vallim, Thomas Q, Sallam, Tamer, Tontonoz, Peter
Publicado 2017

Dietary and Pharmacologic Manipulations of Host Lipids and Their Interaction With the Gut Microbiome in Non-human Primates

por Lang, Jennifer M., Sedgeman, Leslie R., Cai, Lei, Layne, Joseph D., Wang, Zhen, Pan, Calvin, Lee, Richard, Temel, Ryan E., Lusis, Aldons J.
Publicado 2021

Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice

por Ye, Dien, Wu, Congqing, Cai, Lei, Howatt, Deborah A., Liang, Ching-Ling, Katsumata, Yuriko, Mullick, Adam E., Temel, Ryan E., Danser, A.H. Jan, Daugherty, Alan, Lu, Hong S.
Publicado 2023

Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development

por Kim, Seonwook, Yang, Lihua, Kim, Seongu, Lee, Richard G., Graham, Mark J., Berliner, Judith A., Lusis, Aldons J., Cai, Lei, Temel, Ryan E., Rateri, Debra L., Lee, Sangderk
Publicado 2017

Acute Sterol O-Acyltransferase 2 (SOAT2) Knockdown Rapidly Mobilizes Hepatic Cholesterol for Fecal Excretion

por Marshall, Stephanie M., Gromovsky, Anthony D., Kelley, Kathryn L., Davis, Matthew A., Wilson, Martha D., Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Rudel, Lawrence L., Brown, J. Mark, Temel, Ryan E.
Publicado 2014

Reduction of VLDL Secretion Decreases Cholesterol Excretion in Niemann-Pick C1-Like 1 Hepatic Transgenic Mice

por Marshall, Stephanie M., Kelley, Kathryn L., Davis, Matthew A., Wilson, Martha D., McDaniel, Allison L., Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Rudel, Lawrence L., Brown, J. Mark, Temel, Ryan E.
Publicado 2014

XX sex chromosome complement promotes atherosclerosis in mice

por AlSiraj, Yasir, Chen, Xuqi, Thatcher, Sean E., Temel, Ryan E., Cai, Lei, Blalock, Eric, Katz, Wendy, Ali, Heba M., Petriello, Michael, Deng, Pan, Morris, Andrew J., Wang, Xuping, Lusis, Aldons J., Arnold, Arthur P., Reue, Karen, Thompson, Katherine, Tso, Patrick, Cassis, Lisa A.
Publicado 2019

Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides

por Rayner, Katey J., Esau, Christine C., Hussain, Farah N., McDaniel, Allison L., Marshall, Stephanie M., van Gils, Janine M., Ray, Tathagat D., Sheedy, Frederick J., Goedeke, Leigh, Liu, Xueqing, Khatsenko, Oleg G., Kaimal, Vivek, Lees, Cynthia J., Fernandez-Hernando, Carlos, Fisher, Edward A., Temel, Ryan E., Moore, Kathryn J.
Publicado 2011

Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a

por Cheng, Henry S., Besla, Rickvinder, Li, Angela, Chen, Zhiqi, Shikatani, Eric A., Nazari-Jahantigh, Maliheh, Hammoutène, Adel, Nguyen, My-Anh, Geoffrion, Michele, Cai, Lei, Khyzha, Nadiya, Li, Tong, MacParland, Sonya A., Husain, Mansoor, Cybulsky, Myron I., Boulanger, Chantal M., Temel, Ryan E., Schober, Andreas, Rayner, Katey J., Robbins, Clinton S., Fish, Jason E.
Publicado 2017

The long noncoding RNA CHROME regulates cholesterol homeostasis in primate

por Hennessy, Elizabeth J., van Solingen, Coen, Scacalossi, Kaitlyn R., Ouimet, Mireille, Afonso, Milessa S., Prins, Jurrien, Koelwyn, Graeme J., Sharma, Monika, Ramkhelawon, Bhama, Carpenter, Susan, Busch, Albert, Chernogubova, Ekaterina, Matic, Ljubica Perisic, Hedin, Ulf, Maegdefessel, Lars, Caffrey, Brian E., Hussein, Maryem A., Ricci, Emiliano P., Temel, Ryan E., Garabedian, Michael J., Berger, Jeffrey S., Vickers, Kasey C., Kanke, Matthew, Sethupathy, Praveen, Teupser, Daniel, Holdt, Lesca M., Moore, Kathryn J.
Publicado 2018

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

por Lameijer, Marnix, Binderup, Tina, van Leent, Mandy M.T., Senders, Max L., Fay, Francois, Malkus, Joost, Sanchez-Gaytan, Brenda L., Teunissen, Abraham J. P., Karakatsanis, Nicolas, Robson, Philip, Zhou, Xianxiao, Ye, Yuxiang, Wojtkiewicz, Gregory, Tang, Jun, Seijkens, Tom T.P., Kroon, Jeffrey, Stroes, Erik S.G., Kjaer, Andreas, Ochando, Jordi, Reiner, Thomas, Pérez-Medina, Carlos, Calcagno, Claudia, Fischer, Edward A., Zhang, Bin, Temel, Ryan E., Swirski, Filip K., Nahrendorf, Matthias, Fayad, Zahi A., Lutgens, Esther, Mulder, Willem J.M., Duivenvoorden, Raphaël
Publicado 2018