Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach

por Pinto, Erika G., Tempone, Andre G.
Publicado 2018

Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity

por Varela, Marina T., Romanelli, Maiara, Amaral, Maiara, Tempone, Andre G., Fernandes, João Paulo S.
Publicado 2023

Investigation of Structure–Activity Relationships for Benzoyl and Cinnamoyl Piperazine/Piperidine Amides as Tyrosinase Inhibitors

por Varela, Marina T., de Castro Levatti, Erica V., Tempone, Andre G., Fernandes, João Paulo S.
Publicado 2023

Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi

por Amaral, Maiara, Varela, Marina T., Kant, Ravi, Christodoulides, Myron, Fernandes, João Paulo S., Tempone, Andre G.
Publicado 2023

Enyne acetogenins from Porcelia macrocarpa displayed anti-Trypanosoma cruzi activity and cause a reduction in the intracellular calcium level

por Thevenard, Fernanda, Brito, Ivanildo A., Costa-Silva, Thais A., Tempone, Andre G., Lago, João Henrique G.
Publicado 2023

(-)-T-Cadinol—a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)—Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Trypanosoma cruzi...

por dos Santos, Augusto L., Amaral, Maiara, Hasegawa, Flavia Rie, Lago, João Henrique G., Tempone, Andre G., Sartorelli, Patricia
Publicado 2021

Corrigendum: (-)-T-Cadinol, a Sesquiterpene Isolated From Casearia sylvestris (Salicaceae)—Displayed In Vitro Activity and Causes Hyperpolarization of the Membrane Potential of Try...

por dos Santos, Augusto L., Amaral, Maiara, Hasegawa, Flavia Rie, Lago, João Henrique G., Tempone, Andre G., Sartorelli, Patricia
Publicado 2022

Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)

por da Costa-Silva, Thais A., Conserva, Geanne A. Alves, Galisteo, Andrés J., Tempone, Andre G., Lago, João Henrique G.
Publicado 2019

Discovery of New Hits as Antitrypanosomal Agents by In Silico and In Vitro Assays Using Neolignan-Inspired Natural Products from Nectandra leucantha

por Araujo, Sheila C., Sousa, Fernanda S., Costa-Silva, Thais A., Tempone, Andre G., Lago, João Henrique G., Honorio, Kathia M.
Publicado 2021

Biological activity and structure–activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis

por Amaral, Maiara, Asiki, Hannah, Sear, Claire E., Singh, Snigdha, Pieper, Pauline, Haugland, Marius M., Anderson, Edward A., Tempone, Andre G.
Publicado 2023

Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria

por Tempone, Andre G., Pieper, Pauline, Borborema, Samanta E. T., Thevenard, Fernanda, Lago, Joao Henrique G., Croft, Simon L., Anderson, Edward A.
Publicado 2021

Potential of 2-Hydroxy-3-Phenylsulfanylmethyl-[1,4]-Naphthoquinones against Leishmania (L.) infantum: Biological Activity and Structure-Activity Relationships

por Pinto, Erika G., Santos, Isabela O., Schmidt, Thomas J., Borborema, Samanta E. T., Ferreira, Vitor F., Rocha, David R., Tempone, Andre G.
Publicado 2014

Soulamarin Isolated from Calophyllum brasiliense (Clusiaceae) Induces Plasma Membrane Permeabilization of Trypanosoma cruzi and Mytochondrial Dysfunction

por Rea, Alexandre, Tempone, Andre G., Pinto, Erika G., Mesquita, Juliana T., Rodrigues, Eliana, Silva, Luciana Grus M., Sartorelli, Patricia, Lago, João Henrique G.
Publicado 2013

Neolignans isolated from twigs of Nectandra leucantha Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity

por Grecco, Simone S, Costa-Silva, Thais A, Sousa, Fernanda S, Cargnelutti, Stefano B, Umehara, Eric, Mendonça, Poliana S, Tempone, Andre G, Lago, Joao Henrique G
Publicado 2018

Mitochondrial Imbalance of Trypanosoma cruzi Induced by the Marine Alkaloid 6-Bromo-2′-de-N-Methylaplysinopsin

por Romanelli, Maiara M., Amaral, Maiara, Thevenard, Fernanda, Santa Cruz, Lucas M., Regasini, Luis O., Migotto, Alvaro E., Lago, João Henrique G., Tempone, Andre G.
Publicado 2022

A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division

por Amaral, Maiara, de Sousa, Fernanda S., Silva, Thais A. Costa, Junior, Andrés Jimenez G., Taniwaki, Noemi N., Johns, Deidre M., Lago, João Henrique G., Anderson, Edward A., Tempone, Andre G.
Publicado 2019

Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi

por Sear, Claire E., Pieper, Pauline, Amaral, Maiara, Romanelli, Maiara M., Costa-Silva, Thais A., Haugland, Marius M., Tate, Joseph A., Lago, João H. G., Tempone, Andre G., Anderson, Edward A.
Publicado 2020

Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones

por Wulsten, Imke F., Costa-Silva, Thais A., Mesquita, Juliana T., Lima, Marta L., Galuppo, Mariana K., Taniwaki, Noemi N., Borborema, Samanta E. T., Da Costa, Fernando B., Schmidt, Thomas J., Tempone, Andre G.
Publicado 2017

Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of li...

por Morais, Thiago R., Conserva, Geanne A. Alves, Varela, Marina T., Costa-Silva, Thais A., Thevenard, Fernanda, Ponci, Vitor, Fortuna, Ana, Falcão, Amílcar C., Tempone, Andre G., Fernandes, João Paulo S., Lago, João Henrique G.
Publicado 2020

Antitrypanosomal Acetylene Fatty Acid Derivatives from the Seeds of Porcelia macrocarpa (Annonaceae)

por Santos, Luciana de Á., Cavalheiro, Alberto J., Tempone, Andre G., Correa, Daniela S., Alexandre, Tatiana R., Quintiliano, Natalia F., Rodrigues-Oliveira, André F., Oliveira-Silva, Diogo, Martins, Roberto Carlos C., Lago, João Henrique G.
Publicado 2015