Design, Synthesis and Biological Evaluation of Quinazolinamine Derivatives as Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors with Improved Metabolic Stability

por Cai, Chao-Yun, Teng, Qiu-Xu, Murakami, Megumi, Ambudkar, Suresh V., Chen, Zhe-Sheng, Korlipara, Vijaya L.
Publicado 2023

Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR

por Bin Kanner, Yuval, Teng, Qiu-Xu, Ganoth, Assaf, Peer, Dan, Wang, Jing-Quan, Chen, Zhe-Sheng, Tsfadia, Yossi
Publicado 2023

The Multidrug Resistance-Reversing Activity of a Novel Antimicrobial Peptide

por Teng, Qiu-Xu, Luo, Xiaofang, Lei, Zi-Ning, Wang, Jing-Quan, Wurpel, John, Qin, Zuodong, Yang, Dong-Hua
Publicado 2020

Understanding and targeting resistance mechanisms in cancer

por Lei, Zi‐Ning, Tian, Qin, Teng, Qiu‐Xu, Wurpel, John N. D., Zeng, Leli, Pan, Yihang, Chen, Zhe‐Sheng
Publicado 2023

Insights on the structure–function relationship of human multidrug resistance protein 7 (MRP7/ABCC10) from molecular dynamics simulations and docking studies

por Wang, Jing‐Quan, Cui, Qingbin, Lei, Zi‐Ning, Teng, Qiu‐Xu, Ji, Ning, Lin, Lusheng, Liu, Zhijun, Chen, Zhe‐Sheng
Publicado 2021

Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor

por Wu, Zhuo-Xun, Yang, Yuqi, Wang, Jing-Quan, Narayanan, Silpa, Lei, Zi-Ning, Teng, Qiu-Xu, Zeng, Leli, Chen, Zhe-Sheng
Publicado 2021

Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells

por Lei, Zi‐Ning, Teng, Qiu‐Xu, Wu, Zhuo‐Xun, Ping, Feng‐Feng, Song, Peng, Wurpel, John N.D., Chen, Zhe‐Sheng
Publicado 2021

Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells

por Zhang, Yongchao, Wu, Zhuo-Xun, Yang, Yuqi, Wang, Jing-Quan, Li, Jun, Sun, Zoey, Teng, Qiu-Xu, Ashby, Charles R., Yang, Dong-Hua
Publicado 2020

The Resistance of Cancer Cells to Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, is Mediated by the ABCB1 Transporter

por Fu, Han, Wu, Zhuo-Xun, Lei, Zi-Ning, Teng, Qiu-Xu, Yang, Yuqi, Ashby, Charles R., Lei, Yixiong, Lian, Yuyin, Chen, Zhe-Sheng
Publicado 2022

Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells

por Zhang, Wei, Fan, Ying-Fang, Cai, Chao-Yun, Wang, Jing-Quan, Teng, Qiu-Xu, Lei, Zi-Ning, Zeng, Leli, Gupta, Pranav, Chen, Zhe-Sheng
Publicado 2018

PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study

por Yang, Yuqi, Teng, Qiu-Xu, Wu, Zhuo-Xun, Wang, Jing-Quan, Lei, Zi-Ning, Lusvarghi, Sabrina, Ambudkar, Suresh V., Ji, Ning, Chen, Zhe-Sheng
Publicado 2022

MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter: In vitro and in vivo study

por Wu, Zhuo-Xun, Teng, Qiu-Xu, Yang, Yuqi, Acharekar, Nikita, Wang, Jing-Quan, He, Min, Yoganathan, Sabesan, Lin, Jun, Wang, Jian, Chen, Zhe-Sheng
Publicado 2022

Anticancer effect of Indanone-based thiazolyl hydrazone derivative on p53 mutant colorectal cancer cell lines: An in vitro and in vivo study

por Narayanan, Silpa, Teng, Qiu-Xu, Wu, Zhuo-Xun, Nazim, Urooj, Karadkhelkar, Nishant, Acharekar, Nikita, Yoganathan, Sabesan, Mansoor, Najia, Ping, Feng-Feng, Chen, Zhe-Sheng
Publicado 2022

Dual TTK/CLK2 inhibitor, CC‐671, selectively antagonizes ABCG2‐mediated multidrug resistance in lung cancer cells

por Wu, Zhuo‐Xun, Yang, Yuqi, Wang, Guangsuo, Wang, Jing‐Quan, Teng, Qiu‐Xu, Sun, Lingling, Lei, Zi‐Ning, Lin, Lizhu, Chen, Zhe‐Sheng, Zou, Chang
Publicado 2020

OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance

por Yang, Yuqi, Wu, Zhuo-Xun, Wang, Jing-Quan, Teng, Qiu-Xu, Lei, Zi-Ning, Lusvarghi, Sabrina, Ambudkar, Suresh V., Chen, Zhe-Sheng, Yang, Dong-Hua
Publicado 2021

Cabozantinib Reverses Topotecan Resistance in Human Non-Small Cell Lung Cancer NCI-H460/TPT10 Cell Line and Tumor Xenograft Model

por Lei, Zi-Ning, Teng, Qiu-Xu, Gupta, Pranav, Zhang, Wei, Narayanan, Silpa, Yang, Dong-Hua, Wurpel, John N. D., Fan, Ying-Fang, Chen, Zhe-Sheng
Publicado 2021

Signaling pathways and therapeutic interventions in gastric cancer

por Lei, Zi-Ning, Teng, Qiu-Xu, Tian, Qin, Chen, Wei, Xie, Yuhao, Wu, Kaiming, Zeng, Qianlin, Zeng, Leli, Pan, Yihang, Chen, Zhe-Sheng, He, Yulong
Publicado 2022

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

por Ji, Ning, Yang, Yuqi, Cai, Chao-Yun, Lei, Zi-Ning, Wang, Jing-Quan, Gupta, Pranav, Teng, Qiu-Xu, Chen, Zhe-Sheng, Kong, Dexin, Yang, Dong-Hua
Publicado 2018

Venetoclax, a BCL-2 Inhibitor, Enhances the Efficacy of Chemotherapeutic Agents in Wild-Type ABCG2-Overexpression-Mediated MDR Cancer Cells

por Wang, Jing-Quan, Li, Jonathan Y., Teng, Qiu-Xu, Lei, Zi-Ning, Ji, Ning, Cui, Qingbin, Zeng, Leli, Pan, Yihang, Yang, Dong-Hua, Chen, Zhe-Sheng
Publicado 2020

Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells

por Feng, Weiguo, Zhang, Meng, Wu, Zhuo-Xun, Wang, Jing-Quan, Dong, Xing-Duo, Yang, Yuqi, Teng, Qiu-Xu, Chen, Xuan-Yu, Cui, Qingbin, Yang, Dong-Hua
Publicado 2020