Metformin from mother to unborn child – Are there unwarranted effects?

por Nguyen, Linh, Chan, Shiao-Yng, Teo, Adrian Kee Keong
Publicado 2018

Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum

por Teo, Adrian Kee Keong, Valdez, Ivan Achel, Dirice, Ercument, Kulkarni, Rohit N.
Publicado 2014

Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools

por Teo, Adrian Kee Keong, Gupta, Manoj K., Doria, Alessandro, Kulkarni, Rohit N.
Publicado 2015

Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment

por Tan, Lay Shuen, Chen, Juin Ting, Lim, Lillian Yuxian, Teo, Adrian Kee Keong
Publicado 2022

Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own Hands

por Santosa, Munirah Mohamad, Low, Blaise Su Jun, Pek, Nicole Min Qian, Teo, Adrian Kee Keong
Publicado 2016

Protocol for the generation of pancreatic and hepatic progenitors from human pluripotent stem cells for gene regulatory assays

por Tan, Lay Shuen, Chew, Resilind Su Ern, Ng, Natasha Hui Jin, Teo, Adrian Kee Keong
Publicado 2021

Multidisciplinary Effort to Drive Precision-Medicine for the Future

por Kong, Dewei, Yu, Haojie, Sim, Xueling, White, Kevin, Tai, E. Shyong, Wenk, Markus, Teo, Adrian Kee Keong
Publicado 2022

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

por Teo, Adrian Kee Keong, Lau, Hwee Hui, Valdez, Ivan Achel, Dirice, Ercument, Tjora, Erling, Raeder, Helge, Kulkarni, Rohit N.
Publicado 2016

HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

por Chan, Jun Wei, Neo, Claire Wen Ying, Ghosh, Soumita, Choi, Hyungwon, Lim, Su Chi, Tai, E. Shyong, Teo, Adrian Kee Keong
Publicado 2023

PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

por Teo, Adrian Kee Keong, Tsuneyoshi, Norihiro, Hoon, Shawn, Tan, Ee Kim, Stanton, Lawrence W., Wright, Christopher V.E., Dunn, N. Ray
Publicado 2015

FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro

por Lau, Hwee Hui, Amirruddin, Nur Shabrina, Loo, Larry Sai Weng, Chan, Jun Wei, Iich, Elhadi, Krishnan, Vidhya Gomathi, Hoon, Shawn, Teo, Adrian Kee Keong
Publicado 2023

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

por Ng, Natasha Hui Jin, Jasmen, Joanita Binte, Lim, Chang Siang, Lau, Hwee Hui, Krishnan, Vidhya Gomathi, Kadiwala, Juned, Kulkarni, Rohit N., Ræder, Helge, Vallier, Ludovic, Hoon, Shawn, Teo, Adrian Kee Keong
Publicado 2019

BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells

por Loo, Larry Sai Weng, Soetedjo, Andreas Alvin Purnomo, Lau, Hwee Hui, Ng, Natasha Hui Jin, Ghosh, Soumita, Nguyen, Linh, Krishnan, Vidhya Gomathi, Choi, Hyungwon, Roca, Xavier, Hoon, Shawn, Teo, Adrian Kee Keong
Publicado 2020

Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

por Teo, Adrian Kee Keong, Nguyen, Linh, Gupta, Manoj K., Lau, Hwee Hui, Loo, Larry Sai Weng, Jackson, Nicholas, Lim, Chang Siang, Mallard, William, Gritsenko, Marina A., Rinn, John L., Smith, Richard D., Qian, Wei-Jun, Kulkarni, Rohit N.
Publicado 2021

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

por Low, Blaise Su Jun, Lim, Chang Siang, Ding, Shirley Suet Lee, Tan, Yaw Sing, Ng, Natasha Hui Jin, Krishnan, Vidhya Gomathi, Ang, Su Fen, Neo, Claire Wen Ying, Verma, Chandra S., Hoon, Shawn, Lim, Su Chi, Tai, E. Shyong, Teo, Adrian Kee Keong
Publicado 2021

PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development

por Lau, Hwee Hui, Krentz, Nicole A. J., Abaitua, Fernando, Perez-Alcantara, Marta, Chan, Jun-Wei, Ajeian, Jila, Ghosh, Soumita, Lee, Yunkyeong, Yang, Jing, Thaman, Swaraj, Champon, Benoite, Sun, Han, Jha, Alokkumar, Hoon, Shawn, Tan, Nguan Soon, Gardner, Daphne Su-Lyn, Kao, Shih Ling, Tai, E. Shyong, Gloyn, Anna L., Teo, Adrian Kee Keong
Publicado 2023

Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes

por Dirice, Ercument, Kahraman, Sevim, De Jesus, Dario F., El Ouaamari, Abdelfattah, Basile, Giorgio, Baker, Rocky L., Yigit, Burcu, Piehowski, Paul D., Kim, Mi-Jeong, Dwyer, Alexander J., Ng, Raymond W. S., Schuster, Cornelia, Vethe, Heidrun, Martinov, Tijana, Ishikawa, Yuki, Teo, Adrian Kee Keong, Smith, Richard D., Hu, Jiang, Haskins, Kathryn, Serwold, Thomas, Qian, Wei-Jun, Fife, Brian T., Kissler, Stephan, Kulkarni, Rohit N.
Publicado 2019

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

por Carrat, Gaelle R., Haythorne, Elizabeth, Tomas, Alejandra, Haataja, Leena, Müller, Andreas, Arvan, Peter, Piunti, Alexandra, Cheng, Kaiying, Huang, Mutian, Pullen, Timothy J., Georgiadou, Eleni, Stylianides, Theodoros, Amirruddin, Nur Shabrina, Salem, Victoria, Distaso, Walter, Cakebread, Andrew, Heesom, Kate J., Lewis, Philip A., Hodson, David J., Briant, Linford J., Fung, Annie C.H., Sessions, Richard B., Alpy, Fabien, Kong, Alice P.S., Benke, Peter I., Torta, Federico, Teo, Adrian Kee Keong, Leclerc, Isabelle, Solimena, Michele, Wigley, Dale B., Rutter, Guy A.
Publicado 2020